Structure elucidation and vasodilator activity of methoxy flavonols from Calycotome villosa subsp. intermedia

Two flavonols identified as 3,5,7,4′-tetrahydroxy-3′-methoxyflavone (1) and 3,5,7,4′-tetrahydroxy-8-methoxyflavone (2) were isolated from the seeds of Calycotome villosa subsp. intermedia. The structure elucidation of the isolated compounds was performed by the spectroscopic methods (UV, IR, ¹H NMR, ¹³C NMR and MS) and also by a single crystal X-ray analysis in the case of compound (2). Vasodilator activity of compound (2) was demonstrated in isolated rat aorta contracted with high KCl or with noradrenaline.     

Enatioselective quantitative separation of d- and l-thyroxine by molecularly imprinted micro-solid phase extraction silver fiber coupled with complementary molecularly imprinted polymer-sensor

Thyroxine is a known disease biomarker which demands a highly sensitive and selective technique to measure ultratrace level with enantiodifferentiation of its optical isomers (d- and l-), in real samples. In this work, an approach of hyphenation between molecularly imprinted micro-solid phase extraction and a complementary molecularly imprinted polymer-sensor was adopted for enantioseparation, preconcentration, and analysis of d- and l-thyroxine. In both techniques, the same imprinted polymer, coated on a vinyl functionalized self-assembled monolayer modified silver wire, was used as the respective extraction fiber as well as sensor material. This combination enabled enhanced preconcentration of test analyte substantially so as to achieve the stringent limit [limit of detection: 0.0084 ng mL⁻¹, RSD = 0.81%, S/N = 3 (d-thyroxine); 0.0087 ng mL⁻¹, RSD = 0.63%, S/N = 3 (l-thyroxine)] of clinical detection of thyroid-related diseases, without any problems of non-specific false-positive contribution and cross-reactivity.     

Bianchi Type I String Dust Magnetized Cosmological Models in Lyra Geometry

Bianchi type I string dust cosmological models in the presence and absence of magnetic field in the frame work of Lyra geometry are investigated. To get the deterministic model of the universe, we assume that the eigenvalue （σ^11） of shear tensor （σ^ii） is proportional to expansion （θ）. This leads to A = （BC）^n, where A, B, C are metric potentials and n is a constant. To discuss the results in terms of cosmic time t, we have considered n = 1. The physical and geometrical aspects＇ of the models and singularities in the models are also discussed.     

Biogenic Pt uptake and nanoparticle formation in Medicago sativa and Brassica juncea

The ability of the facultative metallophyte plants, Medicago sativa (M. sativa) and Brassica juncea (B. juncea) to accumulate and translocate platinum (Pt) from aqueous substrates is reported. The influence of Pt concentration in the substrate (5, 10, 20, 40 and 80 ppm), exposure time (24, 48 and 72 h) and substrate pH (2, 3, 5, 7 and 9) was determined. In both plants the concentration of Pt increased with substrate concentration and exposure time. Greater accumulation was detected in the roots of M. sativa than B. juncea, up to a maximum of 94.19 mg Pt g^?1 (dry biomass) compared with 38.5 mg Pt g^?1 (dry biomass) following exposure to 80 ppm Pt after 72 h exposure, respectively. However, at lower substrate concentrations (5 and 20 ppm) greater quantities of Pt were detected in the shoots of B. juncea, ranging between 0.02 and 0.32 mg Pt g^?1 (dry biomass) at 5 ppm across the different time intervals studied, compared with 0.02?0.14 mg Pt g^?1 (dry biomass) for M. sativa, suggesting B. juncea to be a better translocator of Pt under idealised conditions at low concentrations. Higher Pt uptake was also observed in acidic media, with a maximum at pH 2 for M. sativa and pH 3 for B. juncea, indicating the role of net surface charge on the bioaccumulation of Pt. Once sequestered Pt(II) was reduced to Pt(0) due to the action of local metabolites. TEM images of M. sativa root samples showed the in vivo formation of Pt nanoparticles between 3 and 100 nm in size and of varying morphologies in the epidermal root cells. In vivo Pt distribution profiles were assessed using proton induced X-ray emission (μ-PIXE) spectroscopy, which showed even distribution across all tissue systems (epidermal, cortical and vascular) within the roots of both M. sativa and B. juncea.     

Bianchi Type I Magnetized Barotropic Perfect Fluid Cosmological Model in General Relativity

Bianchi Type I barotropic perfect fluid cosmological model in presence of magnetic field, is investigated. To get the deterministic model, we have also assumed that σ ₁¹ α θ where σ ₁¹ is the eigen-value of shear tensor σ _i ^j and θ the expansion in the model. The behavior of the model in presence and absence of magnetic field and singularities in the model are also discussed.     

Bianchi type-I bulk viscous fluid string dust magnetized cosmological model in general relativity

Bianchi Type-I magnetized bulk viscous fluid string dust cosmological model is investigated. To get a determinate model, we have assumed the conditions σ ∝θ andζθ = constant where σ is the shear,θ the expansion in the model andζ the coefficient of bulk viscosity. The behaviour of the model in the presence and absence of magnetic field together with physical and geometrical aspects of the model are also discussed.     

Frequency mixing using electromagnetically induced transparency in cold atoms

We report the first experimental demonstration of four-wave mixing using electromagnetically induced transparency in cold atoms. Backward-wave, phase-matched difference-frequency conversion is achieved at optical powers of a few nanowatts and at energies of less than a picojoule.     

Bianchi Type-V Bulk Viscous Barotropic Fluid Cosmological Model with Variable G and Λ

We investigate the Bianchi type-V bulk viscous barotropic fluid cosmological model with variable gravitational constant G and the cosmological constant A, assuming the condition on metric A/A=B/B=C/C=m/tn potential aswhere A, B, and C are functions of time t, while m and n are constants. To obtain the deterministic mo del, we also assume the relations P = p - 3η H, p = 7P, η = ηop^s, where p is the isotropic pressure, η the bulk viscosity,0≤r≤1 H the Hubble constant, ηo and s are constants. Various physical aspects of the model are discussed.The case of n = 1 is also discussed to compare the results with the actual universe.     

Bianchi Type V magnetized string dust cosmological models with Petrov-type degenerate

Bianchi Type V massive string cosmological models with free gravitational field of Petrov Type degenerate in the presence of magnetic field with variable magnetic permeability are investigated. The magnetic field is due to an electric current produced along the x-axis. The F ₂₃ is the only non-vanishing component of electromagnetic field tensor F _ij . Maxwell’s equations F _[ij;k] = 0 and F _;j ^ij = 0 are satisfied by F ₂₃ = constant. The behaviour of the model in the presence and absence of magnetic field and other physical aspects are also discussed.