全文获取类型
收费全文 | 467篇 |
免费 | 3篇 |
国内免费 | 3篇 |
专业分类
化学 | 326篇 |
晶体学 | 6篇 |
力学 | 5篇 |
数学 | 38篇 |
物理学 | 98篇 |
出版年
2019年 | 4篇 |
2017年 | 2篇 |
2016年 | 4篇 |
2014年 | 7篇 |
2013年 | 9篇 |
2012年 | 7篇 |
2011年 | 14篇 |
2010年 | 10篇 |
2009年 | 7篇 |
2008年 | 15篇 |
2007年 | 11篇 |
2006年 | 20篇 |
2005年 | 29篇 |
2004年 | 20篇 |
2003年 | 27篇 |
2002年 | 23篇 |
2001年 | 17篇 |
2000年 | 17篇 |
1999年 | 9篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 5篇 |
1995年 | 9篇 |
1994年 | 7篇 |
1993年 | 6篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 7篇 |
1989年 | 2篇 |
1988年 | 11篇 |
1987年 | 7篇 |
1986年 | 7篇 |
1985年 | 16篇 |
1984年 | 10篇 |
1983年 | 10篇 |
1982年 | 18篇 |
1981年 | 10篇 |
1980年 | 9篇 |
1979年 | 11篇 |
1978年 | 4篇 |
1977年 | 7篇 |
1976年 | 5篇 |
1975年 | 5篇 |
1974年 | 4篇 |
1973年 | 10篇 |
1972年 | 3篇 |
1969年 | 3篇 |
1968年 | 2篇 |
1967年 | 2篇 |
1932年 | 2篇 |
排序方式: 共有473条查询结果,搜索用时 20 毫秒
51.
52.
Lan-Ying Qin Andrew G. Cole Marc-Raleigh Brescia Joan J. Zhang James R. Wareing Juerg Zimmermann John J. Baldwin 《Tetrahedron letters》2010,51(34):4486-4489
A facile synthesis of novel 2-amino-6-arylmethyl-7-carboxamido-7,8-dihydropyrimido[5,4-f][1,4]thiazepin-5-ones is described. The synthesis was developed on solid phase and was applied to provide a series of analogs in good yield. The key reactions are acylation of a cysteine derivative with 2,4-dichloropyrimidine-5-carbonyl chloride followed by cyclization to generate a 6-arylmethyl-7-carboxamido-2-chloro-7,8-dihydropyrimido[5,4-f][1,4]thiazepin-5-one, which is further derivatized with an amine to give the desired 2-amino-6-arylmethyl-7-carboxamido-7,8-dihydropyrimido[5,4-f][1,4]thiazepin-5-one. 相似文献
53.
Lynsey N. Jones Stephen A. Baldwin Peter J. F. Henderson Alison E. Ashcroft 《Rapid communications in mass spectrometry : RCM》2010,24(3):276-284
The D‐galactose‐H+ symport protein, GalP, of Escherichia coli is the bacterial homologue of the human glucose transport protein, GLUT1. Here we demonstrate that mass spectrometry can be used to map modification by covalently bound reagents, and also to detect structural changes in the GalP protein that occur upon substrate binding. The small thiol‐group‐specific reagent N‐ethylmaleimide (NEM) was used to modify the cysteine residues in GalP(His)6 both alone and in the presence of D‐glucose, a known substrate. Employing a mixture of proteolysis and thermal degradation methods, the three cysteine residues were found to undergo sequential reactions with NEM, with Cys374 being modified first, followed by Cys389 and finally Cys19, thus indicating their different accessibilities within the three‐dimensional structure of the protein. Prior binding of the substrate D‐glucose to the protein protected Cys19 and Cys374 against NEM modification, but not Cys389. Cys374 had been expected to be shielded by D‐glucose binding while Cys389 had been expected to be unaffected, consistent with their proposed respective locations in the vicinity of, and distant from, the sugar binding site. However, the inaccessibility of Cys19 was unexpected and suggests a structural change in the protein promoted by D‐glucose binding which changes the proximity of Cys19 with respect to the D‐glucose‐binding site. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
54.
55.
Algebra universalis - 相似文献
56.
Hughes MS McCarthy JE Marsh JN Arbeit JM Neumann RG Fuhrhop RW Wallace KD Znidersic DR Maurizi BN Baldwin SL Lanza GM Wickline SA 《The Journal of the Acoustical Society of America》2007,121(6):3542-3557
Qualitative and quantitative properties of the finite part, H(f), of the Shannon entropy of a continuous waveform f(t) in the continuum limit are derived in order to illuminate its use for waveform characterization. Simple upper and lower bounds on H(f), based on features of f(t), are defined. Quantitative criteria for a priori estimation of the average-case variation of H(f) and log E(f), where E(f) is the signal energy of f(t) are also derived. These provide relative sensitivity estimates that could be used to prospectively choose optimal imaging strategies in real-time ultrasonic imaging machines, where system bandwidth is often pushed to its limits. To demonstrate the utility of these sensitivity relations for this application, a study designed to assess the feasibility of identification of angiogenic neovasculature targeted with perfluorocarbon nanoparticles that specifically bind to alpha(v)beta3-integrin expression in tumors was performed. The outcome of this study agrees with the prospective sensitivity estimates that were used for the two receivers. Moreover, these data demonstrate the ability of entropy-based signal receivers when used in conjunction with targeted nanoparticles to elucidate the presence of alpha(v)beta3 integrins in primordial neovasculature, particularly in acoustically unfavorable environments. 相似文献
57.
Reactions of super-electron-donors (SEDs) derived from 4-dimethylaminopyridine and from N-methylbenzimidazole with α-methoxy-γ-alkoxyalkyl iodides lead to liberation of the γ-alkoxy groups as their alcohols. This is consistent with generation of alkyl radicals from the alkyl halide precursors, and trapping of these radicals by the radical-cation of the SED, followed by a heterolytic fragmentation. 相似文献
58.
59.
125I-[Nle15]-gastrin17 prepared by the iodogen method can be separated by reversed-phase high performance liquid chromatography into two peaks, both of which elute after [Nle15]-gastrin17. Direct determination of the specific activities of the two derivatives by microbore reversed-phase HPLC indicated that they were the mono- and di-iodinated species. In contrast the two peaks obtained with [Met15]-gastrin17 iodinated under the same conditions eluted earlier, relative to the appropriate gastrin17 standard, than the [Nle15]-gastrin derivatives. Treatment of either peak with 0.75 M dithiothreitol at 56 degrees C or 95 degrees C resulted in progressive conversion to compounds migrating in relative positions similar to the 125I-[Nle15]-gastrin17 derivatives. Direct determination of the specific activity of the earlier eluting [Met15]-gastrin17 derivative before reduction indicated that it was the mono-iodinated species. It thus appears likely that iodination of [Met15]-gastrin17 by the iodogen method results predominantly in the formation of mono- and di-125I-[Met sulphoxide15]-gastrin17. To avoid problems arising from oxidation of the methionine residue of gastrin during iodination, the use of 125I-[Nle15]-gastrin17 in binding studies is therefore recommended. 相似文献
60.
A.C. Baldwin J.R. Barker D.M. Golden R. Duperrex H. Van Den Bergh 《Chemical physics letters》1979,62(1):178-180
An energy-grained master equation has been used to model the multiphoton pumping process in SF6. It was found that an energy-dependent absorption cross section that was approximately inversely dependent on the level of excitation was needed to reproductive experimental data on the fraction decomposed per pulse. 相似文献