Deoxygenations of arene oxides. Models for enzymatic deoxygenation

The transfer of oxygen from arene oxides to nitrogen and sulfur-containing substrates is described and the possible biological Significance relative to enzymatic deoxygenation discussed.     

Synthesis and biological evaluation of 1,2,4-triazolidine-3-thiones as potent acetylcholinesterase inhibitors: in vitro and in silico analysis through kinetics,chemoinformatics and computational approaches

Molecular Diversity - We have designed and synthesized a novel acidic ionic liquid and explored its catalytic efficiency for the synthesis of 1,2,4-triazolidine-3-thione derivatives. A simple...     

Chemical Composition and Antimicrobial Activity of Essential Oil from Seeds of Pimpinella heyneana

Chemistry of Natural Compounds -     

Spectrophotometric and TLC Detection Reagent for the Insecticides Dichlorvos (DDVP) and Diptrex (Trichlorfon), and their Metabolites,in Biological Tissues

JPC – Journal of Planar Chromatography – Modern TLC - A new reagent has been developed for spectrophotometric quantification and thin-layer chromatographic (TLC) detection of the...     

Thin Layer Chromatographic Technique for Detection and Identification of Endosulfan Insecticide with m-Dinitrobenzene Reagent

JPC – Journal of Planar Chromatography – Modern TLC - Endosulfan is commonly encountered in poisoning cases in India. In TLC the compound can be detected by spraying the plate with...     

9G DNAChip: a platform for the efficient detection of proteins

According to the proposed DAGON method, the CRP and PSA antigens with the concentrations of 1 pg ml(-1) to 10 pg ml(-1) range can be easily differentiated in the buffer matrix. Moreover, it is for the first time that the multiple antigens with the concentrations of 1 pg ml(-1) and 0.1 pg ml(-1) can be detected in the mixture of the proteins without an amplification technique.     

Novel 1,2,4-triazole analogues as mushroom tyrosinase inhibitors: synthesis,kinetic mechanism,cytotoxicity and computational studies

Molecular Diversity - We have created a novel series of mushroom tyrosinase inhibitors with 1,2,4-triazole as fundamental skeleton. The target compound 1,2,4-triazol-3-ylthio)-N-phenyl acetamide...     

First stereoselective total synthesis of Neocosmosin A: a facile approach

First stereoselective concise synthesis of Neocosmosin A, with in vitro binding affinity for human opioid and cannabinoid receptors, has been reported using readily available starting materials such as methylacetoacetate, cyclohexanone, and homoallyl alcohol involved in the key transformations. There are three fragments involved in the synthesis of target molecule, bearing acid functionality, (R)-pent-4-en-2-ol, and Weinreb amide which are synthesized in four, eight, and three steps, respectively. Then the fragments were coupled in four steps to yield the target molecule in an overall yield of 28.6%.