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91.
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Anthony Bak 《Topology》1975,14(4):367-374
94.
We have used SOM and grid 3D and 4D QSAR schemes for modeling the activity of a series of dihydrofolate reductase inhibitors. Careful analysis of the performance and external predictivities proves that this method can provide an efficient inhibition model. 相似文献
95.
Unified scaling law for earthquakes 总被引:2,自引:0,他引:2
We show that the distribution of waiting times between earthquakes occurring in California obeys a simple unified scaling law valid from tens of seconds to tens of years. The short time clustering, commonly referred to as aftershocks, is nothing but the short time limit of the general hierarchical properties of earthquakes. There is no unique operational way of distinguishing between main shocks and aftershocks. In the unified law, the Gutenberg-Richter b value, the exponent -1 of the Omori law for aftershocks, and the fractal dimension d(f) of earthquakes appear as critical indices. 相似文献
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Dislocation climb mobilities, assuming vacancy bulk diffusion, are derived and implemented in dislocation dynamics simulations to study the coarsening of vacancy prismatic loops in fcc metals. When loops cannot glide, comparison of the simulations with a coarsening model based on the line tension approximation shows good agreement. Dislocation dynamics simulations with both glide and climb are then performed. Allowing for glide of the loops along their prismatic cylinders leads to faster coarsening kinetics, as direct coalescence of the loops is now possible. 相似文献
98.
Hye Jin Bak Moo-Sang Kim Na Young Kim Hye-Jin Go Jin Woo Han Hyae In Jo Sang Jung Ahn Nam Gyu Park Joon Ki Chung Hyung Ho Lee 《Applied biochemistry and biotechnology》2013,169(3):847-861
Cathepsin X, also known as cathepsin Z, is referred to as a “lysosomal proteolytic enzyme” and a member of the peptidase C1 family, which is involved in various biological processes such as immune response, cell adhesion, and proliferation. In the present study, the cDNA of starfish (Asterina pectinifera), which is known to cause serious damage to commercial shellfish mariculture, cathepsin X (ApCtX) was isolated through the combination of homology molecular cloning and rapid amplification of cDNA ends (RACE) methods for the application to find a way to reduce/control starfish densities. The full-length of ApCtX gene was determined to consist of the 2,240 bp nucleotide sequence, which encoded for a preproprotein of 296 amino acids with a molecular mass of about 32.7 kDa. The tissue type expression of ApCtX was determined in various tissues of A. pectinifera and was shown most abundantly in the liver. The cDNA encoding pro-mature enzyme of ApCtX was expressed in Escherichia coli BL21 (DE3) using the pGEX-4T-1 expression vector. Its activity was quantified by cleaving the synthetic peptide Z-Phe-Arg-AMC. The optimal pH for the protease activity was 6.5. The enzymatic activity of proApCtX was reduced by antipain, NEM, EDTA, EGTA, and 1,10-phenanthroline, and the proApCtX enzyme was significantly inhibited by CuSO4, HgCl2, CoCl2, and SDS whereas Triton X-100 and Brij 35 might have potentially acted as an activator. Here, we demonstrated for the first time that the structural features and enzymatic characteristics of Echinoderms cathepsin X are similar to those of the other mammalian and piscine cathepsin X except its pH optimum, and the results of tissue-specific expression might explain their importance in food digestion by hepatic cecain starfish. 相似文献
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Balázs Molnár Gyula Simig Tibor Bakó András Dancsó Balázs Volk 《Tetrahedron letters》2012,53(23):2922-2924
A new and efficient synthesis of 5,6-diaminophthalide and a novel thiadiazolophthalide has been accomplished. Both molecules are useful starting compounds for the construction of more complex heterocyclic systems and for the preparation of bioisosteres of methylenedioxyphenyl derivatives. 相似文献
100.