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Saha S Mahato P Reddy G U Suresh E Chakrabarty A Baidya M Ghosh SK Das A 《Inorganic chemistry》2012,51(1):336-345
A new rhodamine-based receptor, derivatized with an additional fluorophore (quinoline), was synthesized for selective recognition of Hg(2+) and Cr(3+) in an acetonitrile/HEPES buffer medium of pH 7.3. This reagent could be used as a dual probe and allowed detection of these two ions by monitoring changes in absorption and the fluorescence spectral pattern. In both instances, the extent of the changes was significant enough to allow visual detection. More importantly, the receptor molecule could be used as an imaging reagent for detection of Hg(2+) and Cr(3+) uptake in live human cancer cells (MCF7) using laser confocal microscopic studies. Unlike Hg(ClO(4))(2) or Hg(NO(3))(2) salts, HgCl(2) or HgI(2) failed to induce any visually detectable change in color or fluorescence upon interaction with L(1) under identical experimental conditions. Presumably, the higher covalent nature of Hg(II) in HgCl(2) or HgI(2) accounts for its lower acidity and its inability to open up the spirolactam ring of the reagent L(1). The issue has been addressed on the basis of the single-crystal X-ray structures of L(1)·HgX(2) (X(-) = Cl(-) or I(-)) and results from other spectral studies. 相似文献
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S Saha P Mahato M Baidya SK Ghosh A Das 《Chemical communications (Cambridge, England)》2012,48(74):9293-9295
A new coumarin-rhodamine conjugate constitutes a unique example of the interrupted PET coupled TBET response for developing an imaging reagent for determining the intracellular distribution of Hg(2+) in MCF7 cells exposed to [Hg(2+)] as low as 2 ppb. 相似文献
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S. Banerjee S.A. Amin S.K. Baidya N. Adhikari 《SAR and QSAR in environmental research》2020,31(5):325-345
ABSTRACT The zinc-dependent enzyme aminopeptidase N (APN) is a member of the M1 metalloenzyme family. The multi-functionality of APN as a peptidase, a receptor and a signalling molecule has provided it the access to influence a number of disease conditions namely viral diseases, angiogenesis, cellular metastasis and invasion including different cancer conditions. Hence, the development of potent APN inhibitors is a possible route for the treatment of diseases related to the activity of APN. In this study, different QSAR approaches have been adopted to identify the structural features of a group of hydroxamate-based ureido-amino acid derivative APN inhibitors. This study was able to identify different constitutional aspects of these APN inhibitors which are important for their inhibitory potency. Additionally, some of these observations were also aligned with the observations of previously performed QSAR studies conducted on different APN inhibitors. Therefore, the results of this study may help to design potent and effective APN inhibitors in the future. 相似文献
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Ni nanoparticles (NPs)-catalysed synthesis of pyran derivatives was achieved by one-pot three-component reactions of aryl aldehydes/ketone, malononitrile and C–H activated compounds in aqueous medium under ultrasound irradiation. The present approach offer several advantages, such as shorter reaction time, higher yields, and environmental friendliness. 相似文献
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Inside Cover: Significant Structural Differences between Transient Amyloid‐β Oligomers and Less‐Toxic Fibrils in Regions Known To Harbor Familial Alzheimer′s Mutations (Angew. Chem. Int. Ed. 27/2014) 下载免费PDF全文
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A newly synthesized imine-based receptor (L) showed remarkable specificity toward the Hg(2+) ion in aqueous media over other metal ions. Coordination of L to Hg(2+) induces a turn-on fluorescence response. This was explained based on the restricted imine isomerization along with PET on coordination to Hg(2+). X-ray structural evidence tends to favor a C-C bond rotation rather than C═N isomerization for adopting a favorable conformation in L for coordination to Hg(2+). This reagent could be used for imaging the accumulation of Hg(2+) ions in HeLa cells. 相似文献
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Harekrishna Sahoo Mallu Kesava Reddy Isai Ramakrishna Dr. Mahiuddin Baidya 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(5):1592-1596
A copper‐catalyzed 8‐amide chelation‐induced remote C?H amination of quinolines has been developed. This direct amination with readily available azodicarboxylates proceeded with perfect C5‐regioselectivity offering amino‐substituted 8‐aminoquinolines, important bioactive molecular scaffolds, in very high yields (up to 96 %). A single‐electron transfer (SET)‐mediated mechanism with kH/kD=1.1 was proposed after trapping of the radical intermediate. 相似文献
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