Synthesis and Antiproliferative Activity of Some Newly Synthesized Pyrazolopyridine Derivatives

Russian Journal of General Chemistry - A series of pyrazolopyridine derivatives is synthesized from emyl-4-amino-6-memyl-1-(mphtha[1,2-d]-[1,3]tmazol-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate...     

STUDY ON TARGET RESIDUES FROM THE INTERACTION OF COPPER WITH 44MeV/A12C IONS

Cross sections and average forward ranges were determined for 35 target residues from the interaction of copper with 44MeV/A¹²C ions with nuclear chemistry techniques.From these data the isobaric yield distribution,the mass yield distribution and the longitudinal momentum transfer were obtained.The mass yield distribution and the isobaric yield distribution are in good agreement with those calculated from a modified statistical model and corresponding Monte Carlo technique.     

STUDY OF πNN VERTEX FROM HADRON AND QUARK POINT OF VIEW

we have identified the first-order mixing amplitude of πNN process described by the hadron model with the second-order mixing amplitude of the same process described by the quark model.Then the expression for the coupling constant f_π of the πNN vertex with different quark wave functions and gluon propagators in different approximations has been derived. The calculation results of f_π have been compared with experimental data.     

Nuclear Liquid-Gas Phase Transition Shown in Multifragment ation

The Incomplete-Fusion-nagmentation Model has been used to reproduce nicely the experimental evidence of liquid-gas phase transition probed in the reaction of Au + Au at 600A MeV. The analysis of the relative yields of decay modes for the projectile remnant as a function of bound> shows clearly the competition and transformation processes of various decay modes of projectile remnant with decreasing of bound>. The agreement between theoretical and experimental results for the anaJysis of relative yield of decay modes indicates that the experimental evidence of liquid-gas phase transition is composed of the decay mode transformations.     

Strangeness production in pA and AA collisions at 158 A GeV

LUCIAE, a hadronic and string cascade model and its corresponding event generator are used to analyse strangeness production singly and multiply in p-Pb and Pb-Pb collisions at 158 A GeV. Spectra of multiplicity and transverse mass for single (Λ, Λ) and multiple (Ξ-, Ξ-, Ω-, Ω-) strangeness are given. In LUCIAE model it suggests a physical mechanism, i.e. the dependence of the strange quark suppression factor on incident energy, projectile mass and centrality of colliding system might result in increase of yield of strange particles with increasing the above three parameters. Calculations from the model reconstruct well the WA97 experimental data: increase of yield of strange particles with increasing centrality and increase of strangeness enhancement with increasing number of strange quarks, in relativistic nucleus-nucleus collisions.     

Justification of the Kirchhoff hypotheses and error estimation for two-dimensional models of anisotropic and inhomogeneous plates, including laminated plates

Asymptotic analysis of the problem describing deformation ofa thin cylindrical plate with clamped lateral side is performed.The problem is considered under the most general statement withthe plate being laminated and consisting of an arbitrary numberof nonhomogeneous and anisotropic (21 elastic moduli) layers.Explicit integral representations of the differential operatorswhich form the two-dimensional model of the plate are derived.In the case when the elastic moduli of each of the layers areconstant, these integral representations turn into algebraicones. The asymptotic procedure is justified with the help ofa weighted inequality of Korn's type. The error estimates obtainedgive a rigorous mathematical proof of both of Kirchhoff's hypotheses(kinematic and static) and shed light on the well-known intrinsicinconsistency of two of the hypotheses.     

Ultra-incompressible Ternary Diborides Re_（0.5）Ir_（0.5）B_2,Re_（0.5）Tc_（0.5）B_2,Os_（0.5）W_（0.5）B_2 and Os_（0.5）Ru_（0.5）B_2：Density Functional Calculation

In this paper, density functional computations have been applied to the structural, elastic and electronic properties of ternary transition metal diborides Re0.5Ir0.5B2, Re0.5Tc0.5B2, Os0.5W0.5B2 and Os0.5Ru0.5B2 in hexagonal (P63/mmc) and orthorhombic (Pmmn) structures with both local density approximation and generalized gradient approximation. LDA gives smaller lattice parameters and larger elastic moduli than GGA. Both results show that the hexagonal ones are more stable than orthorhombic ones except Os0.5Ru0.5B2. Moreover, the hexagonal structure has superior elastic property than orthorhombic one. Generally speaking, the calculated elastic moduli of Re0.5Ir0.5B2 and Os0.5Ru0.5B2 are smaller than those values of Re0.5Tc0.5B2 and Os0.5W0.5B2 within the same structure because of the filling of antibonding states. The relativistic effects result in weaker bonds of Tc-B (Ru-B) than those of Re-B (Os-B). All the diborides are ultra-incompressible. Re0.5Tc0.5B2 has the largest shear modulus and it is a promising superhard diboride like Os0.5W0.5B2. The elastic properties are in high correlation with the bond strength. The shear moduli are more sensitive than the bulk moduli to the bond strength.     

Androgen receptor antagonists and anti-prostate cancer activities of some synthesized steroidal candidates

In continuation of our previous work, a novel series of steroid derivatives were synthesized and their androgen receptor (AR) antagonist activities and in vivo antiandrogenic properties were evaluated. Twenty-one heterocyclic derivatives containing a cyanopyrane ring fused to a steroidal moiety were conveniently synthesized and screened for their antagonistic, antiandrogen and prostate anticancer activities comparable to that of bicalutamide as the reference control. Some of the compounds exhibited better antagonistic, antiandrogen and prostate anticancer activities than the reference controls. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). Synthetic steroidal structures fused to a substituted cyanopyrane ring seem to be a promising approach in the search for novel leads for potent antagonistic, antiandrogen and prostate anticancer agents.     

催化光度法测定痕量钒——钒(Ⅴ)-溴甲酚紫-过氧化氢体系

催化光度法测定钒已有报道[1～3],在0.45 mol·L-1磷酸介质及加热条件下,过氧化氢氧化溴甲酚紫褪色反应非常缓慢,而痕量钒对此反应具有较高的催化活性,且在一定浓度范围内,钒量与褪色反应程度呈线性关系,据此可建立测定痕量钒的方法.方法的检出限为1.9×10-6g·L-1,测定范围为0.003～1.8 mg·L-1.方法操作简便,重现性好,用于钢样中痕量钒的测定,结果满意.     

酶促开环聚合合成双亲性H型嵌段共聚物及其自组装

通过固定化酶Novozyme435（NV435）催化聚乙二醇（PEG）开环聚合己内酯（CL）得到端基带有羟基的ABA型三嵌段聚合物,用2,2-二氯代乙酰氯将聚合物的端羟基功能化形成H型大分子引发剂,在CuCl／HMTETA体系中引发4-乙烯基吡啶（4VP）进行原子转移自由基聚合反应（ATRP）,得到了具有两亲性的H型五嵌段聚合物（PVP）2-b—PCL-b．PEG-PCL-（PVP）2,用红外光谱（FT IR）,核磁共振（^1H NMR）,凝胶渗透色谱（GPC）对其结构与分子量及其分子量分布进行了表征,结果表明：H型五嵌段聚合物分子量46121g／mol,分子量分布1．30．并利用动态光散射（DLS）和原子力显微镜（AFM）对聚合物在水溶液中的自组装行为进行了研究,H型嵌段聚合物的胶束呈球形结构,平均直径为70nm左右．