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排序方式: 共有363条查询结果,搜索用时 9 毫秒
41.
Ohorodnik Yulia M. Alexander Sikalov A. Khomenko Dmytro M. Doroshchuk Roman O. Raspertova Ilona V. Shova Sergiu Babak Maria V. Lampeka Rostyslav D. 《Transition Metal Chemistry》2022,47(6):213-221
Transition Metal Chemistry - The structures of new p-cymene Ru(II) complexes with 2-(1-methyl-1H-1,2,4-triazol-3-yl)pyridine and 2-(1-methyl-1H-1,2,4-triazol-5-yl)pyridine were established based on... 相似文献
42.
Minofar B Vrbka L Mucha M Jungwirth P Yang X Wang XB Fu YJ Wang LS 《The journal of physical chemistry. A》2005,109(23):5042-5049
Aqueous solvation of benzene dicarboxylate dianions (BCD(2-)) was studied by means of photoelectron spectroscopy and molecular dynamics simulations. Photoelectron spectra of hydrated o- and p-BCD(2-) with up to 25 water molecules were obtained. An even-odd effect was observed for the p-BCD(2-) system as a result of the alternate solvation of the two negative charges. However, the high polarizability of the benzene ring makes the two carboxylate groups interact with each other in p-BCD(2-), suppressing the strength of this even-odd effect compared with the linear dicarboxylate dianions linked by an aliphatic chain. No even-odd effect was observed for the o-BCD(2-) system, because each solvent molecule can interact with the two carboxylate groups at the same time due to their proximity. For large solvated clusters, the spectral features of the solute decreased while the solvent features became dominant, suggesting that both o- and p-BCD(2-) are situated in the center of the solvated clusters. Molecular dynamics simulations with both nonpolarizable and polarizable force fields confirmed that all three isomers (o-, m-, and p-BCD(2-)) solvate in the aqueous bulk. However, upon methylation the hydrophobic forces overwhelm electrostatic interactions and, as a result, the calculations predict that the tetramethyl-o-BCD(2-) is located at the water surface with the carboxylate groups anchored in the liquid and the methylated benzene ring tilted away from the aqueous phase. 相似文献
43.
We present a novel Monte Carlo algorithm for N diffusing finite particles that react on collisions. Using the theory of first-passage processes and time dependent Green's functions, we break the difficult N-body problem into independent single- and two-body propagations circumventing numerous diffusion hops used in standard Monte Carlo simulations. The new algorithm is exact, extremely efficient, and applicable to many important physical situations in arbitrary integer dimensions. 相似文献
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Among a number of different sulfonic acid nanoreactors prepared, 5 having both acidic sites and phenyl groups located inside the mesochannels of SBA-15 was shown to be the most active and reusable catalyst in the von Pechmann reaction. The mesochannels, and covalently anchored organic groups, provide a synergistic means of an efficient approach of the reactants to acidic sites, enough space for the subsequent cyclization, and suitable hydrophobicity to drive out the water byproduct. 相似文献
46.
Ehsan Bahmani Babak Faraji Dizaji Sam Talaei Shahnaz Koushkbaghi Hamid Yazdani Parvaneh Ghaderi-shekhi Abadi Mohammad Akrami Mohsen Shahrousvand Fariborz Sharifian Jazi Mohammad Irani 《先进技术聚合物》2023,34(2):789-799
In the present study, paclitaxel (PTX), multi-walled carbon nanotubes (MWCNTs), and doxorubicin (DOX) have been simultaneously doped into the poly(ϵ-caprolactone) (PCL)/chitosan/zein core-shell nanofibers to increase its cytotoxicity for MCF-7 breast cancers killing. The physico-chemical properties of synthesized nanofibers were determined by scanning electron microscope, Fourier-transform infrared spectroscopy, tensile strength, and degradation rate determinations. The in vitro release studies demonstrated the sustained release of drugs from core-shell nanofibrous scaffold. The cytotoxicity and compatibility of core-shell nanofibers were investigated by their treating with MCF-7 breast cancer cells and L929 normal cells, respectively. PCL/PTX/chitosan/zein/MWCNTs/DOX core-shell nanofibers containing 1 wt% MWCNTs, 100 μg ml−1 DOX and 100 μg ml−1 PTX had a high biocompatibility with a 84% MCF-7 cancer cells killing. The in vivo studies revealed the synergic effects of MWCNTs and anticancer drugs on the tumor inhibition. This method could be considered as a new way for developing of MWCNTs loaded-nanofibers for cancer treatment in future. 相似文献
47.
Seyyed Hossein Miraghaie Ashkan Zandi Zahra Davari Mohamad Sadegh Mousavi-kiasary Zohre Saghafi Ali Gilani Yasin Kordehlachin Fatemeh Shojaeian Amir Mamdouh Zahra Heydari Farid Abedin Dorkoosh Babak Kaffashi Mohammad Abdolahad 《Macromolecular bioscience》2023,23(9):2300181
Pure positive electrostatic charges (PPECs) show suppressive effect on the proliferation and metabolism of invasive cancer cells without affecting normal tissues. PPECs are used for the delivery of drug-loaded polymeric nanoparticles (DLNs) capped with negatively charged poly(lactide-co-glycolide) (PLGA) and Poly(vinyl-alcohol) PVA into the tumor site of mouse models. The charged patch is installed on top of the skin in the mouse models' tumor region, and the controlled selective release of the drug is assayed by biochemical, radiological, and histological experiments on both tumorized models and normal rats' livers. It is found that DLNs synthesized by PLGA show great attraction to PPECs due to their stable negative charges, which would not degrade immediately in blood. The burst and drug release after less than 48h of this synthesized DLNs are 10% and 50%, respectively. These compounds can deliver the loaded-drug into the tumor site with the assistance of PPECs, and the targeted-retarded release will take place. Hence, local therapy can be achieved with much lower drug concentration (conventional chemotherapy [2 mg kg−1] versus DLNs-based chemotherapy [0.75 mg kg−1]) with negligible side effects in non-targeted organs. PPECs have many potential clinical applications for advanced-targeted chemotherapy with the lowest discernible side effects. 相似文献
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The retinal chromophore (11Z)‐3‐diazo‐4‐oxoretinal ( 1 ) with two photo‐labile moieties has been synthesized by semi‐hydrogenation of an 11‐yne precursor with activated Zn in aqueous media. Incorporation of 1 into opsin yielded diazoketo rhodopsin (DK‐Rh), which, upon bleaching, gave rise to intermediates batho‐Rh, lumi‐Rh, meta‐Rh, and meta‐II‐Rh corresponding to those of native Rh but at lower temperatures. Photoaffinity labeling of DK‐Rh and these bleaching intermediates showed that the ionone ring cross‐linked to Trp265 of helix F in DK‐Rh and batho intermediate, and to Ala169 of helix D in lumi, meta‐I, and meta‐II intermediates. These results demonstrate the occurrence of large conformational changes along the visual transduction path, which, in turn, is responsible for activation of the G‐protein. 相似文献
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