超临界CO2法制备头孢唑啉钠脂质体

采用超临界CO2(scCO2)流体代替有机溶剂一步法制备了头孢唑啉钠药物载体脂质体. 研究了该脂质体的尺寸、稳定性和药物的包封率. 结果表明, 脂质体的尺寸和稳定性依赖于制备压力, 脂质体对头孢唑啉钠的包封率与乙醇和脂浓度有关, 采用超临界CO2法制备脂质体的药物包封率比采用薄膜分散法(Bangham method)制备的包封率高.     

Synthesis and magnetic properties of μ-phenolato copper (Ⅱ) binuclear complexes with different exogenous bridges

The syntheses and magnetic properties are reported for a series of copper(Ⅱ) complexes prepared from a pentadentate binucleating ligand 2,6-diformyl-4-methylphenol di(benzoyl-hydrazone) (H3L). These complexes incorporate different exogenous ions (X-) into a bridging position to form copper(Ⅱ) binuclear complexes of the formula [Cu2(H2L)X]2+, where X-= Br-(1), Cl-(2), HO-(3), C2H5O-(4) and C3H3N2- (5). The complexes have been characterized with variable temperature magnetic susceptibility (4.2-300 K) and the observed data were fit to those from a modified Bleaney-Bowers equation by least-squares method, giving the exchange integral 2J = -6.2 cm-1 for 1, -76.4 cm-1 for 2, -241.9 cm-1 for 3, -231.1 cm-1 for 4 and -343.8 cm-1 for 5. This suggested that there is an antiferromagnetic interaction between the Cu(Ⅱ) ions and the sequence of the effect of some exogenous bridging ligands on magnetic coupling is corresponding to that in spectrochemical series.     

1,3-二(2,6-二甲基苯基)-2-四氢咪唑基-苯亚甲基-二吡啶基-二氯合钌 化合物的合成

设计了由1,3-二(2,6-二甲基苯基)-2-四氢咪唑基-苯亚甲基-三苯基膦-二氯合钌(7)和吡啶反应生成无膦型金属钌卡宾化合物1,3-二(2,6-二甲苯基)-2-四氢咪唑基-苯亚甲基-2-吡啶基-二氯合钌(8), 8作为高效催化剂用于丙烯腈和烯丙基苯的交叉交互置换反应. 新化合物7, 8经核磁共振氢谱、碳谱和高分辨率质谱予以证实.     

Sharpless四唑合成中捕获双四唑锌配合物

The reaction of malononitrile with ZnCl₂ and NaN₃ in the presence of 2,2′-bipyridine and water affords the first bis(tetrazole) Zn-complex intermediate, mono(2,2′-bipyridine)bis(tetrazolyl)methane aqua zinc(Ⅱ), [Zn(2,2′-bpy)(BTZ)(H₂O)]·(H₂O)₂ (1) which gives a clue for Demko-Sharpless′ tetrazole synthesis. Crystal data for 1: C₁₃H₁₈N₁₀O₄Zn, M_r=443.74, monoclinic, space group P2₁/c, a=12.5705(18), b=16.078(2), c=9.1921(13)?, β=95.010(3)°, V=1850.7(5)?³, Z=4. CCDC: 197788.     

THE EFFECT OF MODIFICATION OF COORDINATING GROUPS ON THE CATALYTIC BEHAVIORS OF POLYMER CATALYSTS

Several polymer-supported palladium complex catalysts containing two different coordinatinggroups were prepared and the cooperative effect of the coordinating groups on the catalytic behaviorsof polymer catalysts was studied. It was found that poly(acrylic acid-co-acrylonitrile)-Pd complex(PAA-AN-Pd) is a more active and stable catalyst for hydrogenation than both poly(acrylic acid)-Pd and poly(acrylonitrile)-Pd complexes. A marked change of catalytic behaviors of poly(N-substituted maleamic acid-co-styrene)-Pd complexes was observed in comparison with poly(maleicacid-co-styrene)-Pd complex. Acetophenone was reduced to 1-phenyl ethanol by poly(N-phenylmaleamic acid-Co-styrene)-Pd complex (N-1-Pd), but ethylbenzene was obtained using poly(maleicacid-co-styrene)-Pd complex as a catalyst. The influence of solvents, additives and N/Pd gramatomic ratio on the catalytic behaviors of the polymer complexes was investigated.     

硒芳香杂环化合物的光谱和电化学性质

用紫外光谱，荧光光谱和循环伏安法研究了含硒芳香杂环化合物（苤硒脑）在不同溶剂中的谱学和电化学性质，对不同分子结构或取代基的苤硒脑化合物的性质进行了比较，并初步探讨了溶剂对苤硒脑化合物谱学性质的影响规律。     

亚甲胺叶立德参与的[3＋2]环加成反应的最新进展

综述了亚甲胺叶立德的制备、它参与的[3＋2]环加成反应的反应机理、反应选择性及在天然产物全合成中的应用等方面的最新进展.     

β-环糊精交联聚合物树脂相分光光度法测定水中痕量汞

以β-环糊精和环氧氯丙烷为原料合成了环糊精聚合树脂,将其作为显色剂2-[5-溴-(2-吡啶偶氮)]-5-二乙氨基苯酚的载体,采用β-环糊精-2-[5-溴-(2-吡啶偶氮)]-5-二乙氨基苯酚树脂相分光光度法测定微量汞.配合物的最大吸收波长为585nm,表观摩尔吸光系数为8.17×105L/mol·cm,汞含量在0～10μg/25mL范围内服从比尔定律,线性回归方程:y=0.0013 0.0163x,相关系数r=0.9994,加标回收率为98.5%～101.0%,与双硫腙法相比无显著性差异.该方法已用于工业废水中痕量汞的测定,结果令人满意.     

单向应力条件下松弛时间率相关的非线性粘弹性本构模型

基于单向拉伸实验研究和内变量理论 ,提出了一种新的简单的一维非线性粘弹性本构关系 .对两种粘弹性材料 ,即高密度聚乙烯和聚丙烯进行了不同加载速率作用下的拉伸实验研究 ,实验结果表明 ,两种材料的应力应变关系与加载速率相关 ;对材料的应力应变实验数据进行拟合发现 ,材料的松弛时间具有很强的应变率相关性 ,当应变率发生数量级变化时 ,材料的松弛时间也发生数量级的变化 .采用内变量理论 ,导出了在单轴应力条件下松弛时间率相关的非线性粘弹性本构关系的迭代形式 ,并给出其收敛条件 .当采取一次迭代形式时 ,本构关系退化为松弛时间率相关的Maxwell模型 .数值拟合的结果表明 ,一次迭代形式的本构关系就可以很好地拟合和预测实验结果 .     

具有超疏水性质的图案化Ag膜

以重氮树脂(DR)/聚丙烯酸(PAA)自组装膜的微图案作为模板, 通过DNA和聚二甲基二烯丙基氯化铵(PDDA)在模板上的层层沉积制备了图案化的DNA膜. 再在其中进行Ag的化学沉积得到图案化的Ag膜. 最后利用低表面能的十二烷基硫醇对Ag膜进行表面修饰, 制备了具有超疏水性质的图案化Ag膜. 其静态接触角达到约168°.