全文获取类型
收费全文 | 221370篇 |
免费 | 10343篇 |
国内免费 | 6098篇 |
专业分类
化学 | 124305篇 |
晶体学 | 3650篇 |
力学 | 10123篇 |
综合类 | 331篇 |
数学 | 25411篇 |
物理学 | 73991篇 |
出版年
2022年 | 2304篇 |
2021年 | 3140篇 |
2020年 | 3607篇 |
2019年 | 3643篇 |
2018年 | 3717篇 |
2017年 | 3765篇 |
2016年 | 5669篇 |
2015年 | 4382篇 |
2014年 | 6077篇 |
2013年 | 11419篇 |
2012年 | 10405篇 |
2011年 | 11553篇 |
2010年 | 8277篇 |
2009年 | 8046篇 |
2008年 | 9811篇 |
2007年 | 9307篇 |
2006年 | 8673篇 |
2005年 | 7728篇 |
2004年 | 6793篇 |
2003年 | 5954篇 |
2002年 | 5692篇 |
2001年 | 6179篇 |
2000年 | 4727篇 |
1999年 | 3998篇 |
1998年 | 3316篇 |
1997年 | 3178篇 |
1996年 | 3024篇 |
1995年 | 2830篇 |
1994年 | 2694篇 |
1993年 | 2515篇 |
1992年 | 2726篇 |
1991年 | 2627篇 |
1990年 | 2516篇 |
1989年 | 2358篇 |
1988年 | 2291篇 |
1987年 | 2283篇 |
1986年 | 2176篇 |
1985年 | 2762篇 |
1984年 | 2768篇 |
1983年 | 2473篇 |
1982年 | 2547篇 |
1981年 | 2346篇 |
1980年 | 2312篇 |
1979年 | 2444篇 |
1978年 | 2470篇 |
1977年 | 2406篇 |
1976年 | 2454篇 |
1975年 | 2381篇 |
1974年 | 2335篇 |
1973年 | 2520篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
61.
62.
63.
64.
65.
Enantiomeric Cyclic Peptides with Different Caco‐2 Permeability Suggest Carrier‐Mediated Transport 下载免费PDF全文
B. Sc. Eduard Puig Prof. Dr. Beat Ernst Prof. Dr. Horst Kessler 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(22):8023-8027
Recently, oral absorption of cyclic hexapeptides was improved by N‐methylation of their backbone amides. However, the number and position of N‐methylations or of solvent exposed NHs did not correlate to intestinal permeability, measured in a Caco‐2 model. In this study, we investigate enantiomeric pairs of three polar and two lipophilic peptides to demonstrate the participation of carrier‐mediated transporters. As expected, all the enantiomeric peptides exhibited identical lipophilicity (logD7.4) and passive transcellular permeability determined by the parallel artificial membrane permeability assay (PAMPA). However, the enantiomeric polar peptides exhibited different Caco‐2 permeability (Papp) in both directions a–b and b–a. The same trend was observed for one of the lipophilic peptide, whereas the second lipophilic enantiomer pair showed identical Caco‐2 permeability (within the errors). These findings provide the first evidence for the involvement of carrier‐mediated transport for peptides, especially for those of polar nature. 相似文献
66.
Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry 下载免费PDF全文
Dongyu Gu Yi Yang Qibin Chen Madina Habasi Jiangyu Zhao Haji Akber Aisa 《Biomedical chromatography : BMC》2015,29(4):595-603
Rupestonic acid, a potential anti‐influenza agent, is an important and characteristic compound in Artemisia rupestris L., a well‐known traditional Uighur medicine for the treatment of colds. In the present study, high‐performance liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry was used to detect and identify the metabolites in rat urine after oral administration of rupestonic acid. A total of 10 metabolites were identified or partially characterized. The structure elucidations of the metabolites were performed by comparing the changes in accurate molecular masses and fragment ions with those of the parent compound. The results showed that the main metabolites of rupestonic acid in rat urine were formed by oxidation, hydrogenation and glucuronidation. A metabolism pathway was proposed for the first time based on the characterized structures. This metabolism study can provide essential information for drug discovery, design and clinical application of rupestonic acid. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
67.
68.
69.
Lithium-sulfur batteries (LSBs) with high energy density and low cost have been recognized as one of the most promising next-generation energy storage systems. Although it has taken decades of development, the practical application of LSBs has been hindered by several inherent obstacles, particularly the severe shuttle effect and sluggish reaction kinetics in the sulfur cathode. Various strategies have been proposed to address these problems via rational design of electrode materials and configurations. Freestanding sulfur cathode could be a promising strategy to improve the sulfur mass loading at the cathode level and energy density of LSBs. This minireview will briefly summary the recent advances in freestanding cathodes for LSBs. The advantages and disadvantages of various freestanding cathodes are discussed and the prospects for the development of flexible cathodes are envisioned. 相似文献
70.
Youchao Wang Na Tian Weize Sun Boerhan Rena Xusheng Guo Yang Feng Chao Li Xuesong Wang Qianxiong Zhou 《Particle & Particle Systems Characterization》2020,37(5):2000045
Photoactivated chemotherapy (PACT) has appealing merits over traditional chemotherapy as well as photodynamic therapy (PDT) by virtue of its spatial and temporal control on drug activity and oxygen-independent mechanisms of action. However, the short photoactivation wavelengths, e.g., visible light–activated Ru(II)-based PACT agents, limit the clinical application severely. In this work, a facile construction of supramolecular nanoparticles from a poly(ethylene glycol) (PEG)-modified [Ru(dip)2(py-SO3)]+ (abbreviated as Ru-PEG, dip = 4,7-diphenyl-1,10-phenanthroline, py-SO3 = pyridine-2-sulfonate) and 1,3-phenylenebis(pyren-1-ylmethanone) (BP) is shown. While Ru-PEG may undergo photoinduced ligand dissociation and release anticancer species of [Ru(dip)2(H2O)2]2+, BP has extremely large two-photon absorption cross sections (δ2) in the NIR region and intense fluorescence over the wavelengths where Ru-PEG has strong absorption. Thus, two-photon excitation of BP followed by an efficient Förster resonance energy transfer (FRET) from BP to Ru-PEG may lead to a potent inactivation against cisplatin-resistant cancer cells and 3D multicellular tumor spheroids (MCTSs). The residue fluorescence of BP also allows the cellular uptake of the particles to be visualized. This work provides a universal and convenient strategy to realize theranostic PACT in the ideal phototherapeutic window of 650–900 nm. 相似文献