Inclusion complexes of the natural product gossypol. Recognition by gossypol of halogeno methanes. Structure of the dichloromethane complex of gossypol and single crystal conservation after decomposition

The structures of gossypol complexes are extremely sensitive to the halogenomethane present as the guest; e.g. changing the number of Cl atoms in chloromethane derivatives changes the structure of the gossypol complex. The crystals of C₃₀H₃₀O₈·CH₂Cl₂ are monoclinic, space groupC2/c,a=21.320(4),b=19.199(6),c=15.765(2)Å, =113.05(2)^o,V=5916(2)ų,Z=8,D _x=1.35 g/cm³,T=295 K. The structure has been solved by direct methods and refined to the finalR value of 0.084 for 1828 reflections. In the structure H-bonded gossypol molecules form columns, generating channels in the structure which are filled by guest molecules. After decomposition (desolvation) monocrystals of the complexes are conserved without destruction, in which there are rather wide and empty channels though slightly smaller than in the complex. An attempt is made to explain some peculiarities of the behavior of the gossypol polymorph formed on the basis of its structure with empty channels. Supplementary data relevant to this article have been deposited with the British Library Publication No. SUP 82165 (17 pages).     

Structures of nitramine and isonitramine — Alkaloids of a new type from plants of the genusNitraria

The proof of the structures of two isomeric alkaloids — nitramine and isonitramine — from two species of plants of the genusNitraria is given. Their diastereoisomerism with respect to the C₇ asymmetric atom has been established. This is the first time that alkaloids with the structure of 2-azaspiro[5,5]undecan-7-ol have been found.     

Synthesis and transformations of metallacycles. 23. Cp2TiCl2-Catalyzed cyclometallation of fullerene C60 with EtAlCl2

1-Ethyl-2,3-fullerenoaluminacyclopropanes (EtAl)_n(²-C₆₀) were synthesized by the reaction of fullerene C₆₀ with an excess of EtAlCl₂ in the presence of Mg and using Cp₂TiCl₂ as the catalyst in a THF--toluene solution at 20 °C. Deuterolysis of fullerenoaluminacyclopropanes afforded a mixture of deuteriofullerenes C₆₀D_m, where m = 6--12.     

Isolation, purification, and study of some properties of the lysl-, phenylalanyl-, and aspartyl-tRNA synthetases from the fungus Verticillium dahliae

Conclusions Relatively highly purified preparations of lysyl-, phenylalanyl- and aspartyl-tRNA synthetases have been isolated from the 12-day mycelium of a strongly virulent form of the fungusV. dahliae and some of their physicochemical properties have been studied.Institute of Biochemistry, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 229–233, March–April, 1974.     

Synthesis and transformations of metallacycles. 30. Aluminacyclopentanes in the synthesis of secondary and tertiary alcohols

A method for the synthesis of secondary and tertiary alcohols was developed. The method is based on cycloalumination of olefins with trialkylalanes in the presence of Zr-containing catalysts followed by the CuCl-catalyzed in situ reaction of the corresponding aluminacyclopentanes with aldehydes or ketones.     

Structure of vasicol

The structure of bromovasicol has been established on the basis of the results of x-ray structural analysis as 4-bromo-2-(3-hydroxy-2-oxypyrrolinomethl)aniline. Vasicol was isolated from the plantPeganum harmala in the form of 2-(3-hydroxy-2-oxopyrrolidinomethyl)aniline.Institute of the Chemistry of Plants Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 18–23, January–February, 1989.     

Molecular and crystal structure of tetrahydroneosophoramine

The structure of tetrahydroneosophoramine has been studied by x-ray structural analysis. Rings A, B, and C have the chair conformation, and ring D the half-chair conformation. On the basis of a semiquantitative analysis it has been shown that the strains in the molecules of tetrahydroneosophoramine and of matrine are of the same order of magnitude.Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of Crystallography, Academy of Sciences of the USSR, Moscow. V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 751–757, November–December, 1981.