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排序方式: 共有131条查询结果,搜索用时 15 毫秒
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Emmy Fadhiza Damit Nor Saadah M. Yusof Azhar Ariffin M. Niyaz Khan 《Journal of the Iranian Chemical Society》2012,9(5):723-727
The values of pseudo-first-order rate constants (k obs) for the acetolysis of phthalic anhydride (PAn) increase from 6.60?×?10?7 to 31.5?×?10?7?s?1 with the increase in temperature from 30 to 50?°C. These values of k obs give activation parameters ?H* and ?S* as 14.4?±?0.4?kcal?mol?1 and ?39.1?±?1.3?cal?K?1?mol?1, respectively. The values of k obs remain essentially unchanged with the increase in the content of CS (CS?=?CH3CN or THF) from 0 to 40?% v/v in mixed AcOH?CCS solvents. These observations have been explained qualitatively. 相似文献
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The interaction of competing agents is described by classical game theory. It is now well known that this can be extended to the quantum domain, where agents obey the rules of quantum mechanics. This is of emerging interest for exploring quantum foundations, quantum protocols, quantum auctions, quantum cryptography, and the dynamics of quantum cryptocurrency, for example. In this paper, we investigate two-player games in which a strategy pair can exist as a Nash equilibrium when the games obey the rules of quantum mechanics. Using a generalized Einstein–Podolsky–Rosen (EPR) setting for two-player quantum games, and considering a particular strategy pair, we identify sets of games for which the pair can exist as a Nash equilibrium only when Bell's inequality is violated. We thus determine specific games for which the Nash inequality becomes equivalent to Bell's inequality for the considered strategy pair. 相似文献
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Sanjay Kumar Sherif A. El-Kafrawy Shiv Bharadwaj S. S. Maitra Thamir A. Alandijany Arwa A. Faizo Aiah M. Khateb Vivek Dhar Dwivedi Esam I. Azhar 《Molecules (Basel, Switzerland)》2022,27(8)
Zika virus (ZIKV) has been characterized as one of many potential pathogens and placed under future epidemic outbreaks by the WHO. However, a lack of potential therapeutics can result in an uncontrolled pandemic as with other human pandemic viruses. Therefore, prioritized effective therapeutics development has been recommended against ZIKV. In this context, the present study adopted a strategy to explore the lead compounds from Azadirachta indica against ZIKV via concurrent inhibition of the NS2B-NS3 protease (ZIKVpro) and NS5 RNA dependent RNA polymerase (ZIKVRdRp) proteins using molecular simulations. Initially, structure-based virtual screening of 44 bioflavonoids reported in Azadirachta indica against the crystal structures of targeted ZIKV proteins resulted in the identification of the top four common bioflavonoids, viz. Rutin, Nicotiflorin, Isoquercitrin, and Hyperoside. These compounds showed substantial docking energy (−7.9 to −11.01 kcal/mol) and intermolecular interactions with essential residues of ZIKVpro (B:His51, B:Asp75, and B:Ser135) and ZIKVRdRp (Asp540, Ile799, and Asp665) by comparison to the reference compounds, O7N inhibitor (ZIKVpro) and Sofosbuvir inhibitor (ZIKVRdRp). Besides, long interval molecular dynamics simulation (500 ns) on the selected docked poses reveals stability of the respective docked poses contributed by intermolecular hydrogen bonds and hydrophobic interactions. The predicted complex stability was further supported by calculated end-point binding free energy using molecular mechanics generalized born surface area (MM/GBSA) method. Consequently, the identified common bioflavonoids are recommended as promising therapeutic inhibitors of ZIKVpro and ZIKVRdRp against ZIKV for further experimental assessment. 相似文献
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Sharifah Nurfadhlin Afifah Syed Azhar Siti Efliza Ashari Norhazlin Zainuddin Masriana Hassan 《Molecules (Basel, Switzerland)》2022,27(1)
Advanced hybrid component development in nanotechnology provides superior functionality in the application of scientific knowledge for the drug delivery industry. The purpose of this paper is to review important nanohybrid perspectives in drug delivery between nanostructured lipid carriers (NLC) and hydrogel systems. The hybrid system may result in the enhancement of each component’s synergistic properties in the mechanical strength of the hydrogel and concomitantly decrease aggregation of the NLC. The significant progress in nanostructured lipid carriers–hydrogels is reviewed here, with an emphasis on their preparation, potential applications, advantages, and underlying issues associated with these exciting materials. 相似文献
99.
Muhammad Imran Irfan Fareeha Amjad Azhar Abbas Muhammad Fayyaz ur Rehman Fariha Kanwal Muhammad Saeed Sami Ullah Changrui Lu 《Molecules (Basel, Switzerland)》2022,27(11)
The present work reports the synthesis, characterization, and antimicrobial activities of adipic acid-capped silver nanoparticles (AgNPs@AA) and their utilization for selective detection of Hg2+ ions in an aqueous solution. The AgNPs were synthesized by the reduction of Ag+ ions with NaBH4 followed by capping with adipic acid. Characterization of as-synthesized AgNPs@AA was carried out by different techniques, including UV–Visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Dynamic Light Scattering (DLS), and zeta potential (ZP). In the UV–Vis absorption spectrum, the characteristic absorption band for AgNPs was observed at 404 nm. The hydrodynamic size of as-synthesized AgNPs was found to be 30 ± 5.0 nm. ZP values (−35.5 ± 2.4 mV) showed that NPs possessed a negative charge due to carboxylate ions and were electrostatically stabilized. The AgNPs show potential antimicrobial activity against clinically isolated pathogens. These AgNPs were found to be selectively interacting with Hg2+ in an aqueous solution at various concentrations. A calibration curve was constructed by plotting concentration as abscissa and absorbance ratio (AControl − AHg/AControl) as ordinate. The linear range and limit of detection (LOD) of Hg2+ were 0.6–1.6 μM and 0.12 μM, respectively. A rapid response time of 4 min was found for the detection of Hg2+ by the nano-probe. The effect of pH and temperature on the detection of Hg2+ was also investigated. The nano-probe was successfully applied for the detection of Hg2+ from tap and river water 相似文献
100.
Freeha Hafeez Ameer Fawad Zahoor Azhar Rasul Asim Mansha Razia Noreen Zohaib Raza Kulsoom Ghulam Ali Ali Irfan Gamal A. El-Hiti 《Molecules (Basel, Switzerland)》2022,27(15)
Piperazine-based dithiocarbamates serve as important scaffolds for numerous pharmacologically active drugs. The current study investigates the design and synthesis of a series of dithiocarbamates with a piperazine unit as well as their biological activities. Under ultrasound conditions, the corresponding piperazine-1-carbodithioates 5a–5j were synthesized from monosubstituted piperazine 2 and N-phenylacetamides 4a–4j in the presence of sodium acetate and carbon disulfide in methanol. The structures of the newly synthesized piperazines were confirmed, and their anti-lung carcinoma effects were evaluated. A cytotoxic assay was performed to assess the hemolytic and thrombolytic potential of the synthesized piperazines 5a–5j. The types of substituents on the aryl ring were found to affect the anticancer activity of piperazines 5a–5j. Piperazines containing 2-chlorophenyl (5b; cell viability = 25.11 ± 2.49) and 2,4-dimethylphenyl (5i; cell viability = 25.31 ± 3.62) moieties demonstrated the most potent antiproliferative activity. On the other hand, piperazines containing 3,4-dichlorophenyl (5d; 0.1%) and 3,4-dimethylphenyl (5j; 0.1%) rings demonstrated the least cytotoxicity. The piperazine with the 2,5-dimethoxyphenyl moiety (5h; 60.2%) showed the best thrombolytic effect. To determine the mode of binding, in silico modeling of the most potent piperazine (i.e., 5b) was performed, and the results were in accordance with those of antiproliferation. It exhibits a similar binding affinity to PQ10 and an efficient conformational alignment with the lipophilic site of PDE10A conserved for PQ10A. 相似文献