Monetary aspects of acquiring technology for price discrimination of a perishable storable product

The remaining shelf-life of perishable storable products can become an additional source of volatility among consumers and a matter for price discrimination. Two models are presented. Both models assume the retailer has the information about consumers’ sensitivity to the remaining shelf-life (eg, their purchasing history). Only the first assumes the retailer has also the technology for price discrimination. An optimal solution for each model is analytically obtained and a numerical example that illustrates the significance is introduced. Numerical illustration indicates that a policy of identical prices for all based on accurate information about consumer sensitivity to remaining shelf-life results in a profit that is just slightly smaller per unit of time compared with the price discrimination policy. Opposing, the numerical illustration also indicates significant difference between the models with respect to their impact on consumers. Following these results, the regulator may consider suggesting the retailer monetary incentives in order to utilize price discrimination.     

Identification of G‐nerve agents at picogram levels from complex organic samples containing hydrocarbon interferences by aqueous extraction,followed by derivatization and liquid chromatography‐mass spectrometry analysis

The chromatograms obtained from the gas chromatography‐electron ionization mass spectrometric (GC‐EI‐MS) analysis of extracts containing G‐nerve agents in the presence of diesel, gasoline, etc., are dominated by hydrocarbon backgrounds that “mask” the G‐nerve agents, leading to severe difficulties in identification. This paper presents a practical solution for this challenge by transferring the G‐nerve agents from the organic phase into the aqueous phase using liquid‐liquid extraction (LLE), followed by derivatization with 2‐[(dimethylamino)methyl]phenol (2‐DMAMP), allowing ultrasensitive LC‐ESI‐MS/MS analysis of the G‐derivatives. The proposed approach enables rapid identification of trace amounts of G‐nerve agents with limits of identification (LOIs) at the pg/mL scale.     

Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy

Oligonucleotide-protein conjugates have important applications in biomedicine. Simple and efficient methods are described for the preparation of these conjugates. Specifically, we describe a new method in which a bifunctional linker is attached to thiol-oligonucleotide to generate a reactive intermediate that is used to link to the protein. Having similar conjugation efficacy compared with the classical method in which the bifunctional linker is attached first to the protein, this new approach produces significantly more active conjugates with higher batch to batch reproducibility. In a second approach, direct conjugation is proposed using oligonucleotides carrying carboxyl groups. These methodologies have been applied to prepare nanoconjugates of an engineered nanoparticle protein carrying a T22 peptide with affinity for the CXCR4 chemokine receptor and oligomers of the antiproliferative nucleotide 2’-deoxy-5-fluorouridine in a very efficient way. The protocols have potential uses for the functionalization of proteins, amino-containing polymers or amino-lipids in order to produce complex therapeutic nucleic acid delivery systems.     

Simple route to strong-field coherent control

Coherent-control schemes to manipulate weak-field interactions are generally invalid at stronger fields, since strong-field interactions are accompanied by level power broadenings and level shifts that usually elude simple analytical treatments. Here we show that a broad subgroup of weak-field solutions (those with real fields, i.e., fields with only one quadrature in the complex plane) can be extended to the strong-field regime while retaining their properties. The salient feature of these fields is a symmetry that cancels out power broadening effects. Such fields can be generated from ultrashort coherent pulses or from incoherent broadband down-converted light. Weak-field coherent-control approaches based on these solutions can therefore be extended to the strong-field regime as we demonstrate in a two-photon absorption experiment in atomic cesium.     

Geometrical phase image encryption obtained with space-variant subwavelength gratings

An optical encryption method based on a geometrical phase produced by space-variant polarization manipulation is presented. The decrypted picture is retrieved either by a polarization measurement of the beam emerging from the encrypted element or by a single intensity measurement of the beam transmitted through the encrypted element followed by an optical key element. Both elements are realized by use of computer-generated space-variant subwavelength dielectric gratings. Theoretical analyses of the optical concept are presented along with experimental results.     

Space-variant polarization manipulation for far-field polarimetry by use of subwavelength dielectric gratings

A method for polarimetric measurement that uses a discrete space-variant subwavelength dielectric grating is presented. One retrieves the polarization state by measuring the far-field intensity of a beam emerging from the grating followed by a polarizer. The analysis for a partially polarized, quasi-monochromatic beam is performed by use of the beam coherence polarization matrix along with an extended van Cittert-Zernike theorem. We experimentally demonstrate polarization measurements of both fully and partially polarized light.     

Discrete multi-armed bandits and multi-parameter processes

Summary The general multi-armed bandit problem is reformulated and solved as a control problem over a partially ordered set. The approach taken provides a technically convenient framework for bandit-like problems. It also adds insight to the structure of strategies over partially ordered sets.     

Optimal Configurations of General Job Shops

In this paper we study the problem of minimizing the expected number of jobs in a single class general open queueing network model of a job shop. This problem was originally posed by Buzacott and Shanthikumar [2] and solved by them for a special case. We extend their work in this paper. We derive feasibility conditions that simplify the analysis of the problem. We show that the optimal configuration can be completely characterized when both the utilizations of the machine centers are high and there are a large number of servers at each machine center. We also derive conditions under which the optimization problem reduces to solving a concave or a convex program and provide conditions under which the uniform flow line and the symmetric job shop (or variants of these) are optimal configurations for the job shop.     

Nonlinear interactions with an ultrahigh flux of broadband entangled photons

We experimentally demonstrate sum-frequency generation with entangled photon pairs, generating as many as 40,000 photons per second, visible even to the naked eye. The nonclassical nature of the interaction is exhibited by a linear intensity dependence of the nonlinear process. The key element in our scheme is the generation of an ultrahigh flux of entangled photons while maintaining their nonclassical properties. This is made possible by generating the down-converted photons as broadband as possible, orders of magnitude wider than the pump. This approach can be applied to other nonlinear interactions, and may become useful for various quantum-measurement tasks.     

Fabrication of coaxial nanowire heterostructures: SiO x nanowires with conformal TiO2 coatings

Silica nanowires, grown via the active oxidation of a silicon substrate, have been coated with TiO₂ using two coating methods: solution-based deposition of Ti-alkoxides and atomic layer deposition. Analysis of as-deposited and annealed films shows that it is possible to produce stable conformal coatings of either the anatase or rutile phases of TiO₂ on nanowires with diameters greater than 100 nm when annealed between 500–600°C and 800–900°C, respectively, with annealing at higher temperatures (1050°C) producing coatings with a highly facetted rutile morphology. The efficacy of the process is shown to depend on nanowire diameter, with nanowires having diameters less than about 100 nm fusing together during solution-based coating and decomposing during TiO₂ atomic layer deposition. The use of a suitable buffer layer is shown to be an effective means of minimizing nanowire decomposition. Finally, annealing coated nanowires under active oxidation conditions (1100°C) is shown to be an effective technique for depositing additional conformal SiO _x coatings, thereby providing a means of fabricating multi-layered coaxial nanostructures.