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41.
Mateo-Alonso A Ehli C Guldi DM Prato M 《Journal of the American Chemical Society》2008,130(45):14938-14939
A rotaxane scaffold is used to align three photo/electroactive units along a supramolecular redox gradient leading to a cascade of through-space charge transfer reactions. 相似文献
42.
Mateo-Alonso A Guldi DM Paolucci F Prato M 《Angewandte Chemie (International ed. in English)》2007,46(43):8120-8126
Molecular machines are molecular-scale devices that carry out predetermined tasks derived from molecular motion. This Minireview illustrates how fullerenes can be used as multitask building blocks in molecular machinery, providing new perspectives for fullerenes. Indeed, C(60) can be applied as a photo- and electroactive stopper owing to its size, as a probe for molecular motion as a result of its well-defined physicochemical properties, and to induce motion through pi-pi interactions. Such molecular motion can be employed to modulate light-driven electron-transfer events, extending the potential applications of molecular machines to the typical fields of application of fullerenes. 相似文献
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Mateo-Alonso A Fioravanti G Marcaccio M Paolucci F Rahman GM Ehli C Guldi DM Prato M 《Chemical communications (Cambridge, England)》2007,(19):1945-1947
Herein we describe a fullerene rotaxane, in which shuttling between two well-defined and distant co-conformations is both induced and monitored by the C60 stopper. 相似文献
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Synthesis and Biological Evaluation of RGD Peptidomimetic–Paclitaxel Conjugates Bearing Lysosomally Cleavable Linkers 下载免费PDF全文
Alberto Dal Corso Dr. Michele Caruso Dr. Laura Belvisi Dr. Daniela Arosio Prof. Dr. Umberto Piarulli Dr. Clara Albanese Dr. Fabio Gasparri Dr. Aurelio Marsiglio Dr. Francesco Sola Dr. Sonia Troiani Dr. Barbara Valsasina Dr. Luca Pignataro Dr. Daniele Donati Prof. Dr. Cesare Gennari 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(18):6921-6929
Two small‐molecule–drug conjugates (SMDCs, 6 and 7 ) featuring lysosomally cleavable linkers (namely the Val–Ala and Phe–Lys peptide sequences) were synthesized by conjugation of the αvβ3‐integrin ligand cyclo[DKP–RGD]‐CH2NH2 ( 2 ) to the anticancer drug paclitaxel (PTX). A third cyclo[DKP–RGD]–PTX conjugate with a nonpeptide “uncleavable” linker ( 8 ) was also synthesized to be tested as a negative control. These three SMDCs were able to inhibit biotinylated vitronectin binding to the purified αVβ3‐integrin receptor at nanomolar concentrations and showed good stability at pH 7.4 and pH 5.5. Cleavage of the two peptide linkers was observed in the presence of lysosomal enzymes, whereas conjugate 8 , which possesses a nonpeptide “uncleavable” linker, remained intact under these conditions. The antiproliferative activities of the conjugates were evaluated against two isogenic cell lines expressing the integrin receptor at different levels: the acute lymphoblastic leukemia cell line CCRF‐CEM (αVβ3?) and its subclone CCRF‐CEM αVβ3 (αVβ3+). Fairly effective integrin targeting was displayed by the cyclo[DKP–RGD]–Val–Ala–PTX conjugate ( 6 ), which was found to differentially inhibit proliferation in antigen‐positive CCRF‐CEM αVβ3 versus antigen‐negative isogenic CCRF‐CEM cells. The total lack of activity displayed by the “uncleavable” cyclo[DKP–RGD]–PTX conjugate ( 8 ) clearly demonstrates the importance of the peptide linker for achieving the selective release of the cytotoxic payload. 相似文献
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Colodrero RM Olivera-Pastor P Losilla ER Hernández-Alonso D Aranda MA Leon-Reina L Rius J Demadis KD Moreau B Villemin D Palomino M Rey F Cabeza A 《Inorganic chemistry》2012,51(14):7689-7698
Multifunctional materials, especially those combining two or more properties of interest, are attracting immense attention due to their potential applications. MOFs, metal organic frameworks, can be regarded as multifunctional materials if they show another useful property in addition to the adsorption behavior. Here, we report a new multifunctional light hybrid, MgH(6)ODTMP·2H(2)O(DMF)(0.5) (1), which has been synthesized using the tetraphosphonic acid H(8)ODTMP, octamethylenediamine-N,N,N',N'-tetrakis(methylenephosphonic acid), by high-throughput methodology. Its crystal structure, solved by Patterson-function direct methods from synchrotron powder X-ray diffraction, was characterized by a 3D pillared open framework containing cross-linked 1D channels filled with water and DMF. Upon H(2)O and DMF removal and subsequent rehydration, MgH(6)ODTMP·2H(2)O (2) and MgH(6)ODTMP·6H(2)O (3) can be formed. These processes take place through crystalline-quasi-amorphous-crystalline transformations, during which the integrity of the framework is maintained. A water adsorption study, at constant temperature, showed that this magnesium tetraphosphonate hybrid reversibly equilibrates its lattice water content as a function of the water partial pressure. Combination of the structural study and gas adsorption characterization (N(2), CO(2), and CH(4)) indicates an ultramicroporous framework. High-pressure CO(2) adsorption data are also reported. Finally, impedance data indicates that 3 has high proton conductivity σ = 1.6 × 10(-3) S cm(-1) at T = 292 K at ~100% relative humidity with an activation energy of 0.31 eV. 相似文献
48.
Aurelio Carboni Stefano Kasangian Ross Street 《Journal of Pure and Applied Algebra》1984,33(3):259-267
A new kind of bicategorical limit is used to characterize bicategories of the form Spant() and Rel() where in the former case is a category with pullbacks and in the latter is a regular category. The characterization of Rel() differs from those in the literature which require involutions on the bicategories. 相似文献
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