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281.
Bovee TF Schoonen WG Hamers AR Bento MJ Peijnenburg AA 《Analytical and bioanalytical chemistry》2008,390(4):1111-1119
Recently we constructed yeast cells that either express the human estrogen receptor α or the human androgen receptor in combination
with a consensus ERE or ARE repeat in the promoter region of a green fluorescent protein (yEGFP) read-out system. These bioassays
were proven to be highly specific for their cognate agonistic compounds. In this study the value of these yeast bioassays
was assessed for analysis of compounds with antagonistic properties. Several pure antagonists, selective estrogen receptor
modulators (SERMs) and plant-derived compounds were tested. The pure antiestrogens ICI 182,780 and RU 58668 were also classified
as pure ER antagonists in the yeast estrogen bioassay and the pure antiandrogen flutamide was also a pure AR antagonist in
the yeast androgen bioassay. The plant-derived compounds flavone and guggulsterone displayed both antiestrogenic and antiandrogenic
activities, while 3,3′-diindolylmethane (DIM) and equol combined an estrogenic mode of action with an antiandrogenic activity.
Indol-3-carbinol (I3C) only showed an antiandrogenic activity. Coumestrol, genistein, naringenin and 8-prenylnaringenin were
estrogenic and acted additively, while the plant sterols failed to show any effect. Although hormonally inactive, in vitro
and in vivo metabolism of the aforementioned plant sterols may still lead to the formation of active metabolites in other
test systems. 相似文献
282.
Microextraction across supported liquid membranes forced by pH gradients and electrical fields 总被引:1,自引:0,他引:1
Gjelstad A Andersen TM Rasmussen KE Pedersen-Bjergaard S 《Journal of chromatography. A》2007,1157(1-2):38-45
The present work has for the first time compared extraction of basic analytes across a supported liquid membrane (SLM) based on (1) passive diffusion in a pH gradient sustained over the SLM and (2) electrokinetic migration in an electrical field sustained over the SLM. For the passive diffusion experiments, performed as liquid-phase microextraction (LPME), five basic drugs were extracted under strong agitation from alkaline samples (10mM NaOH), through 2-nitrophenyl octylether immobilized in the pores of a porous hollow fibre of polypropylene (SLM), and into 25 microl of 10mM HCl as the acceptor solution. The experiments based on electrokinetic migration, performed as electro membrane isolation (EMI), were conducted under strong agitation from acidic samples (10mM HCl), through the same SLM as in LPME, and into 25 microl of 10mM HCl as the acceptor solution. Whereas LPME relied on diffusion and to some extent also convection as the principal mechanisms of mass transfer, mass transfer in EMI also included a strong contribution from electrokinetic migration. Thus, extraction kinetics was improved by a factor between 6 and 17 utilizing EMI instead of LPME. This major difference in terms of speed was especially pronounced from small sample volumes (150 microl), and suggest that EMI may be a very interesting future concept for miniaturized sample preparation. In addition to improved extraction kinetics, extraction rates were strongly compound dependent in EMI, opening the possibility to control the extraction selectivity by the extraction time. 相似文献
283.
Astrid Lumetzberger Werner Löwe Manuela Weber Peter Luger 《Journal of heterocyclic chemistry》2007,44(1):155-159
The (Z)‐3‐substituted 2‐indolinone 6 was prepared using the aldehydes 4 and 8 unknown up to now and 2‐indolinone. 相似文献
284.
Characterization of sulfonated azo dyes and aromatic amines by pyrolysis gas chromatography/mass spectrometry 总被引:1,自引:0,他引:1
Sixteen sulfonated and unsulfonated azo dyes as well as eleven sulfonated and unsulfonated aromatic amines were analyzed and qualitatively characterized by means of pyrolysis gas chromatography/mass spectrometry at different temperatures. Aniline and aminonaphthalene were found to be the dominant pyrolysis products of sulfonated aromatic amines and dyes. Azo dye and dye class specific key compounds such as benzidine, vinyl-p-base and 4-aminoazobenzene could be identified by pyrolysis gas chromatography/mass spectrometry of commercial acid, cationic, direct, reactive and solvent dyes. 500 degrees C was the optimal pyrolysis temperature for most of the pyrolyzed compounds. The method was applied to a dried sample of a textile wastewater concentrate from a dyeing process. Reactive azo dyes of the group of Remazol dyes and anthraquinone dyes could be identified as the major compounds of the sample. The finding of caprolactam (a printing additive) suggests that the wastewater contained effluent from a process of heat-activated printing with reactive dyes. p-Chloraniline, a banned aromatic amine, was identified. Chemical reduction of the wastewater sample prior to pyrolysis resulted in the release of volatile aromatic amines and aided the classification of several products of pyrolysis. 相似文献
285.
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287.
Jette Bjerre Hansen Christian Grøn Ulla Lund Bertil Magnusson Astrid Nordbotten Anke Oberender Michael H. Ramsey 《Accreditation and quality assurance》2007,12(7):377-381
A workshop on uncertainty in sampling was held in Hillerød, Denmark, on 12–13 April 2007 to launch a new handbook on sampling quality assurance and uncertainty estimation. The participants of the workshop were approximately 60 delegates from 15 European countries, representing institutions performing sampling, users of the data, research institutions, as well as accreditation bodies. Materials from the workshop, including examples, tools, and calculation aids for the work can be found at http://www.samplersguide.com. The Nordtest handbook Uncertainty from sampling will be made available on the Nordtest web site at http://www.nordicinnovation.net/nordtest.cfm under NT technical reports, report number NT tec 604. Until the final report is available on the Nordtest web site, an advance draft of the Nordtest handbook is available from http://www.samplersguide.com. 相似文献
288.
The formation of superlattices in blends of a series of asymmetric BSV triblock terpolymers and symmetric SV or VC diblock copolymers is investigated with S being polystyrene, B being poly(1,2‐butadiene), V being poly(2‐vinylpyridine), and C being poly(cyclohexyl methacrylate). All of these triblock terpolymers and diblock copolymers by themselves self‐assemble into lamellae. Apart from various core shell morphologies, in these blends some new unexpected superstructures were obtained.
289.
290.
Trifonov Lena Yurchenko Mariya Skjesol Astrid Cohen Guy Espevik Terje Korshin Edward E. Grøvdal Lene Melsæther Husebye Harald Gruzman Arie 《Molecular diversity》2022,26(4):2175-2188
Molecular Diversity - IFN-β is a cytokine that plays a significant role in the immune system. Inhibition of IFN-β might be used as a therapeutic approach to treat septic shock. A... 相似文献