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排序方式: 共有187条查询结果,搜索用时 218 毫秒
141.
Kishor Mazumder Asma Aktar Priyanka Roy Biswajit Biswas Md. Emran Hossain Kishore Kumar Sarkar Sitesh Chandra Bachar Firoj Ahmed A. S. M. Monjur-Al-Hossain Koichi Fukase 《Molecules (Basel, Switzerland)》2022,27(9)
Cancer is a disorder that rigorously affects the human population worldwide. There is a steady demand for new remedies to both treat and prevent this life-threatening sickness due to toxicities, drug resistance and therapeutic failures in current conventional therapies. Researchers around the world are drawing their attention towards compounds of natural origin. For decades, human beings have been using the flora of the world as a source of cancer chemotherapeutic agents. Currently, clinically approved anticancer compounds are vincristine, vinblastine, taxanes, and podophyllotoxin, all of which come from natural sources. With the triumph of these compounds that have been developed into staple drug products for most cancer therapies, new technologies are now appearing to search for novel biomolecules with anticancer activities. Ellipticine, camptothecin, combretastatin, curcumin, homoharringtonine and others are plant derived bioactive phytocompounds with potential anticancer properties. Researchers have improved the field further through the use of advanced analytical chemistry and computational tools of analysis. The investigation of new strategies for administration such as nanotechnology may enable the development of the phytocompounds as drug products. These technologies have enhanced the anticancer potential of plant-derived drugs with the aim of site-directed drug delivery, enhanced bioavailability, and reduced toxicity. This review discusses mechanistic insights into anticancer compounds of natural origins and their structural activity relationships that make them targets for anticancer treatments. 相似文献
142.
Asma Hrizi Manon Cailler Moufida Romdhani-Younes Yvan Carcenac Jrme Thibonnet 《Molecules (Basel, Switzerland)》2021,26(17)
An approach for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction of compounds 1-(but-2-ynyl)-1H-indole-2-carbonitriles and 1-benzyl-3-iodo-1H-indole-2-carbonitriles is described. The reactivity of indole derivatives with iodine at position 3 was studied using cross-coupling reactions. The Sonogashira, Suzuki–Miyaura, Stille and Heck cross-couplings afforded a variety of di-, tri- and tetra-substituted indole-2-carbonitriles. 相似文献
143.
Asma Nsira Hasan Mtiraoui Sami Chniti Hanan Al-Ghulikah Rafik Gharbi Moncef Msaddek 《Molecules (Basel, Switzerland)》2022,27(13)
Novel 1,2,3-triazolo-linked-1,5-benzodiazepinones were designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction (CuAAC). The chemical structures of these compounds were confirmed by 1H NMR, 13C NMR, HMBC, HRMS, and elemental analysis. The compounds were screened for their in vitro antibacterial and antifungal activities. Several compounds exhibited good to moderate activities compared to those of established standard drugs. Furthermore, the binding interactions of these active analogs were confirmed through molecular docking. 相似文献
144.
Md. Nazmul Hossain Umakanta Sarker Md. Sharif Raihan Asma A. Al-Huqail Manzer H. Siddiqui Shinya Oba 《Molecules (Basel, Switzerland)》2022,27(6)
This is the first attempt to evaluate the impact of four salinity levels on the color parameters, pigments, polyphenols, flavonoids, and antioxidant capacities of four promising A. lividus genotypes. The color parameters, such as the yellowness/blueness (b*) and the chroma (C*); the antioxidant components, such as the polyphenols and flavonoids; and the antioxidant capacities of the leaves were remarkably increased by 39, 1, 5, 10 and 43%, respectively, at 50 mM of NaCl, and by 55, 5, 60, 34, 58 and 82%, respectively, at 100 mM NaCl concentrations. The green tower and SA6 genotypes were identified as tolerant varieties. The total phenolic content (TPC) and the total flavonoid content (TFC) played vital roles in scavenging reactive oxygen species (ROS), and they would be beneficial for the human diet and would serve as good antioxidants for the prevention of aging, and they are also essential to human health. A correlation study revealed the strong antioxidant capacities of the pigments and antioxidant components that were studied. It was revealed that A. lividus could tolerate a certain level of salinity stress without compromising the antioxidant quality of the final product. Taken together, our results suggest that A. lividus could be a promising alternative crop for farmers, especially in saline-prone areas in the tropical and subtropical regions. 相似文献
145.
In the present research, Fe3O4 and WS2 nanoparticles immobilized on or in KIT-6 (KIT: Korea Institute of Science and Technology) pores (KIT-6/WS2-Fe3O4) were synthesized and studied as a photocatalyst for degradation of representative chlorpyrifos as an organophosphorus pesticide. In addition, the KIT-6/WS2-Fe3O4 photocatalyst was characterized by different methods such as TEM, FESEM-EDS-Mapping, XRD, and N2 adsorption/desorption surface area, in order to understand their morphology, structural, and physical properties. The photocatalytic performance of this photocatalyst was investigated for degradation of chlorpyrifos by visible light irritation. The effects of variables such as chlorpyrifos concentration, KIT-6/WS2-Fe3O4 nanocatalyst amount, pH, and irradiation time on chlorpyrifos degradation efficiency was studied by central composite design with response surface methodology. The optimum conditions for CP degradation were obtained by 50 mg KIT-6/WS2-Fe3O4 nanocatalyst, and 7.2 ppm chlorpyrifos solution with pH = 6, at 52 min. The pseudo-first-order model with rate constants equal to 0.069 min−1 as best choice efficiency described the chlorpyrifos degradation process according to Langmuir-Hinshelwood kinetic. 相似文献
146.
Azam Muhammad Arshad Asma Aslam Muhammad Gulzar Sadia 《Accreditation and quality assurance》2019,24(3):227-235
Accreditation and Quality Assurance - To analyze drinking water dataset, various statistical methods have been applied, including discriminant analysis, logistic regression and cluster analysis, to... 相似文献
147.
Edward-Sam Edwin Prabhakaran Vasantha-Srinivasan Sengottayan Senthil-Nathan Muthiah Chellappandian Sengodan Karthi Radhakrishnan Narayanaswamy Vethamonickam Stanley-Raja Haridoss Sivanesh Ramakrishnan Ramasubramanian Asma A. Al-Huqail Faheema Khan Patcharin Krutmuang Ahmed Abdel-Megeed Aml Ghaith Chae-Hoon Paik 《Molecules (Basel, Switzerland)》2021,26(19)
Spodoptera litura Fab. is a polyphagous pest causing damage to many agriculture crops leading to yield loss. Recurrent usage of synthetic pesticides to control this pest has resulted in resistance development. Plant-derived diterpenoid compound andrographolide was isolated from the leaves of Andrographis paniculata. It was analysed by gas chromatography-mass spectroscopy and quantified by HPLC. Nutritional indices and digestive enzymatic profile were evaluated. Third, fourth and fifth instar larvae were treated with different concentrations of andrographolide. At 3, 6 and 9 ppm-treated concentrations the larvae showed decreased RGR, RCR, ECI, ECD values with adverse increase in AD. The digestive enzymes were significantly inhibited when compared with control. Conspicuously, andrographolide showed pronounced mortality of S. litura by inhibition of enzyme secretion and intake of food. The binding ability of andrographolide with CYTP450 showed high affinity with low binding energy. Andrographolide has the potential to be exploited as a biocontrol agent against S. litura as an eco-friendly pesticide. 相似文献
148.
In this paper, a new (3+1)-dimensional nonlinear evolution equation is introduced, through the generalized bilinear operators based on prime number p=3. By Maple symbolic calculation, one-, two-lump, and breather-type periodic soliton solutions are obtained, where the condition of positiveness and analyticity of the lump solution are considered. The interaction solutions between the lump and multi-kink soliton, and the interaction between the lump and breather-type periodic soliton are derived, by combining multi-exponential function or trigonometric sine and cosine functions with a quadratic one. In addition, new interaction solutions between a lump, periodic-solitary waves, and one-, two- or even three-kink solitons are constructed by using the ansatz technique. Finally, the characteristics of these various solutions are exhibited and illustrated graphically. 相似文献
149.
150.