58.
Bimetallic chlorodi-/triorganotin(IV) derivatives of general formulas R
2(H
2O)SnLCSSSn(Cl)R
2 (R=Me:
1; Ph:
2) and R
3Sn(Na)LCSSSnR
3·H
2O (R=Bu:
3; Ph:
4) were prepared by reaction of iminodiacetic acid disodium salt hydrate (Na
2LH) with CS
2 and R
2SnCl
2/R
3SnCl in methanol. The reaction between Na
2LH, CS
2, and PdCl
2 produced [Na
2LCSS]
2Pd·2H
2O (
5) which was treated with R
3SnCl to synthesize the heterobimetallic derivatives [R
3Sn(Na)LCSS]
2Pd·2H
2O (R=Me:
6; Ph:
7). The complexes were characterized by microanalysis, spectroscopic, and thermogravimetric analyses. Elemental analysis data, mass fragmentation, and thermal degradation patterns supported the molecular composition of the complexes. FT-IR data indicated monodentate binding of carboxylate while a chelating coordination mode of the dithiocarboxylate was verified in the solid state. A five-coordinate tin(IV) was demonstrated in the solid state. In solution, a tetrahedral/trigonal bipyramidal configuration around Sn(IV) and a square planar geometry of Pd(II) was indicated by multinuclear NMR (
1H and
13C) and UV-visible studies. The Pd(II) derivatives showed interaction with salmon sperm-DNA and caused an inhibition of alkaline phosphatase (ALPs). The antibacterial/antifungal potential of the coordination products varied with the nature of incorporated metal and a substitution pattern at tin(IV); the palladium metallation decreased the antimicrobial activities. The triorganotin(IV) products exhibited more powerful action against bacteria/fungi as compared to their diorganotin(IV) counterparts. The complexes displayed sufficiently lower hemolytic effects
in vitro as compared to triton X-100 and slightly higher than PBS.
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