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71.
Rodríguez-Delgado A Cámpora J Naz AM Palma P Reyes ML 《Chemical communications (Cambridge, England)》2008,(41):5230-5232
Separation of a diiminopyridine iron(II) complex into its rac- and meso- diastereoisomers provides for first time the opportunity of observing the enantiomorphic site control competing with the chain-end control mechanism in a non-metallocene catalyst system. 相似文献
72.
The first integrals and exact solutions of mathematical models of epidemiology: a susceptible‐infected‐recovered‐infected (SIRI) model and a tuberculosis model with demographic growth are analyzed. These models are represented by systems of first‐order nonlinear ordinary differential equations, and this system is replaced by one which contains a second‐order ordinary differential equation. The partial Lagrangian approach is then utilized to derive the first integrals of these models. Several cases arise. Then, we utilize the derived first integrals to construct exact solutions for the models under investigation and determine new solutions. The dynamic properties of these models are studied too. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
73.
Hira Aslam Shazia Shukrullah Muhammad Yasin Naz Hareem Fatima Sami Ullah Abdullah G. Al-Sehemi 《Particle & Particle Systems Characterization》2021,38(12):2100179
Magnetically guided drug transportation is a technique in which magnetic pharmaceutical transporters in organisms are controlled by applied magnetic forces to deliver drugs to the desired location. Different magnetic drug delivery systems (MDDSs) are developed to treat a variety of illnesses, particularly cancer and neurological disorders. However, a unique magnetic setup is required in each application for an effective magnetically guided drug aiming to direct the drug-carrying nanocarriers to the intended area. The current and future perspectives of MDDS are investigated in this study by considering their biological functions, deliverable efficiency, complexity, and the nature of the externally applied magnetic field. Despite the fact that MDDSs have low cytotoxicity, regulated magneto reactivity, extended circulation lifespan, and high surface stability, very few clinical studies have been conducted to date in order to achieve optimized therapeutic efficacy before entering the market. In recent studies, the development of novel magnetic medication transporting carriers is preferred over direct magnetic medication administration. Better functional magnetic targeting technologies are required for such breakthroughs to enter clinical trials. Because MDDSs are unlikely to work in all clinical situations, more focused research is needed to replace or improve the strategy for treating multiple illnesses. 相似文献
74.
Muhammad U. Farooq Muhammad Y. Naz Muhammad I. Hussain Shazia Shukrullah Mohamed M. Makhlouf 《Particle & Particle Systems Characterization》2021,38(7):2100073
As several multi-target drug delivery approaches are successfully identified through preclinical screening, their clinical success is often hampered by challenges such as poor circulation stability, dissimilarities in the pharmacokinetics of different drugs, as well as targeting inefficiency. Gold nanoparticles (AuNPs) are adopted as promising nanocarriers in the co-delivery of multiple therapeutic drugs for combination therapy. The pH-responsive AuNPs are synthesized and incorporated with multiple chemotherapeutic drugs, such as doxorubicin and bleomycin. Such structures can work as drug carriers to treat cervical carcinoma by adopting a quality by design approach. The designed nanocarrier is characterized by adopting a range of physicochemical and morphological techniques. In vitro drug release and cytotoxicity of optimized nanocarriers are assessed to cervical tumor epithelial cells. The results highlight the notable advantages of colloidal AuNPs, including sustained drug release, therapeutic agent delivery with high stability, and biocompatibility for more effective treatment of cervical carcinoma. Furthermore, by improving the biodistribution and/or bioavailability profiles, it is believed that the two-in-one approach may therefore give evidence on the fate of co-loaded nanocarrier as a promising trajectory for successful clinical translation against ovarian carcinoma to achieve maximum therapeutic synergy for an individual patient. 相似文献
75.
A practical, chemoselective oxidation of alcohols employing catalytic quantities of DDQ as the oxidant and Mn(OAc)(3) as the co-oxidant is described. Electron-rich benzylic alcohols are oxidized efficiently to their corresponding carbonyls, but less electron-rich benzylic alcohols remain unchanged. Allylic alcohols are rapidly oxidized to their corresponding aldehyde or ketone counterparts in high yields. This protocol is operationally simple, employs an inexpensive source of Mn(OAc)(3), has short reaction times, and exhibits a significant chemoselectivity favoring allylic alcohols over benzylic alcohols. This procedure also avoids the use of very large excesses of reagents and sometimes poor reproducibility that characterize previously developed reagents such as MnO(2). 相似文献
76.
The petroleum ether and chloroform extracts of the root of Piper chaba showed antimicrobial, antileishmanial and cytotoxic activities. Further bioactivity-guided fractionation led to the isolation of Bornyl piperate (1), piperlonguminine (2) and piperine (3). This is the first report of isolation of compounds (1) and (2) from P. chaba. It was observed that the isolated compounds (1 and 2) showed potent antifungal activity when compared with standard drug Nystatin, and significant cytotoxic activity with the IC?? values of 0.76 and 0.83?μg?mL?1, respectively. These compounds were also found to have weak antibacterial and antileishmanial activities. This is the first report about the antileishmanial activity of Piper isolates. 相似文献
77.
78.
Asia AnjumMuhammad Ayub Masood Khan 《Communications in Nonlinear Science & Numerical Simulation》2012,17(1):472-482
In this paper, we establish the starting solutions for oscillating motions of an Oldroyd-B fluid between two side walls perpendicular to a plane wall. The expressions for the velocity field and the associated tangential stress at the bottom wall are obtained, presented under integral and series form. These satisfy all imposed initial and boundary conditions. The obtained solutions are graphically analyzed for the variations of interesting flow parameters. In the absence of side walls, all solutions that have been obtained reduce to those corresponding to the motion over an infinite plate. Moreover, the obtained solutions can be specialized to give similar solutions for Maxwell, second grade and Newtonian fluids performing the same motions. 相似文献
79.
We present the experimental observation of 1D and 2D self-accelerating nonlinear beams in quadratic media, which are also the first nonlinear self-accelerating beams in any symmetric nonlinearity. Notably, we show that the intensity peaks of the first and second harmonics are asynchronous with respect to one another, but the coupled harmonics exhibit joint acceleration within the nonlinear medium. Finally, we demonstrate the impact of self-healing effects on the jointly accelerating first and second harmonics. 相似文献
80.
The unsteady MHD boundary layer flow of a micropolar fluid near the forward stagnation point of a two dimensional plane surface
is investigated by using similarity transformations. The transformed nonlinear differential equations are solved by an analytic
method, namely homotopy analysis method (HAM). The solution is valid for all values of time. The effect of MHD and porous
medium, non dimensional velocity and the microrotation are presented graphically and discussed. The coefficient of skin friction
is also presented graphically. 相似文献