A series of novel imidazo[1,2-b]pyridazin-3-yl acetamide derivatives (9a-9j) were synthesized from a 3,6-dichloropyridazine. We have developed a simple strategy for the synthesis of functionally diverse imidazole, and pyridiazine derivatives were reported via a series of steps. The work involves bicyclic imidazo-pyridazine ring formation, halogenation, cynation, hydrolysis, peptide coupling, and Buchwald reaction. The structure of the synthesized compounds was confirmed by IR, 1H NMR, 13C NMR,19F NMR, mass spectra, and elemental analysis, and purity is checked by HPLC. All synthesized compounds were screened for anticancer activity against A-549 and Du-145 cancer cell lines by MTT assay. The preliminary bioassay suggests that most of the compounds show anti-proliferation with different degrees; doxorubicin was used as positive control. The synthesized compound shows IC50 values in the range of 1.74μM to 16.17μM in both cell lines. The compounds 9e , 9g , and 9h were active compared with doxorubicin in both the cell lines. The compounds having cyclopentyl ring are active compared with higher and lower carbon analogues. 相似文献
Multidentate 1,3,5-benzenetricarboxylic acid (organic linker), Zn (II) based Zn-BTC has been synthesized via electrochemical method. Quantitative and Qualitative analyses of synthesized metal–organic framework (MOF) have been done using Fourier Transform Infrared (FTIR) Spectroscopy, Energy Dispersive X- Ray Spectroscopy (EDS), and Photoluminescence (PL). Powder X-Ray Diffraction (PXRD) and Scanning Electron Microscopy (SEM) have been used for crystallographic and morphological & topographical analyses, respectively. Crystallographic studies confirm the formation of face-centered cubic (fcc) crystal structure with good crystallinity. Photo-catalytic activity of synthesized MOF has been tested using Methylene Blue (MB) dye as a test contaminant in aqueous media under sunlight irradiation. Recorded results reveal that the synthesized MOF efficiently degrade MB dye upto 96% under sunlight exposure after 270 min. Photoluminescence studies indicate that Zn-BTC could be used as an efficient material for sensing of nitroaromatic compounds (NACs): 4-Nitroaniline (4-NA), 2-Nitroaniline (2-NA), 3- Nitroaniline (3-NA), 2,4-Dinitrotoulene (2,4-DNT), 4-Nitrotoulene (4-NT) in N,N’-Dimethylformamide (DMF) by fluorescence quenching and shows maximum quenching efficiency towards 3-NA (72.80%). Notably, the variation in luminescence intensity of 3-NA@Zn-BTC shows a linear relationship over its different concentrations from 0–1000 ppb range with KSV?=?2.7?×?104 M?1 and R2?=?0.9924 with limit of detection 0.889 ppb (6.43 µM) (LOD). The possible ways of luminescence quenching are successfully explained by the combination of Photoinduced Electron Transfer (PET) and Resonance Energy Transfer (RET) mechanisms. Additionally, the Density Functional Theory (DFT) calculations have been employed to support the experimental results. Zn-BTC fully demonstrates the power of a multi component MOF, which provides a feasible pathway for the design of novel material towards fast responding luminescence sensing and photocatalytic degradation of pollutants.
Triphenylantimony(V) heteroleptic derivatives containing substituted oximes and morpholine dithiocarbamate of the type Ph3Sb[R(R′)C:NO]2[S2CN(CH2CH2)2O] (where R = ─C6H5, R′ = ─CH3 (I); R = ─C6H4CH3, R′ = ─CH3 (II); R = ─C6H4Cl, R′ = ─CH3 (III); R = ─C6H4Br, R′ = ─CH3 (IV); R = ─C6H4OH, R′ = ─H (V); R(R′)C = CCH2(CH2)3CH2 (VI)) were synthesized by successive substitution reactions of triphenylantimony(V) dibromide with the sodium salt of substituted oximes and morpholine dithiocarbamate in unimolar ratio. All these newly synthesized derivatives were characterized using physicochemical and elemental analyses and tentative structures have been proposed on the basis of infrared, (1H, 13C) NMR and liquid chromatography–mass spectra. Spectral data revealed that the oxime behaves in a monodentate manner whereas morpholine dithiocarbamate behaves in an anisobidentate manner and thus distorted octahedral geometry has been proposed for these derivatives. Nanometric particle size (ca 25 nm) and monoclinic crystal system have been determined using power X‐ray diffraction data of two representative derivatives. Furthermore, these newly synthesized derivatives were screened against two bacteria, Bacillus subtilis (Gram‐positive) and Escherichia coli (Gram‐negative), to evaluate their antibacterial potential. Derivative VI exhibited maximum zone of inhibition (30 mm) against E. coli. Additionally two derivatives (I and II) were tested for their antioxidant potential, with derivative II exhibiting higher antioxidant potential (233 μM g?1). Structure–activity relationships were also investigated. 相似文献
Compartmentalization of biochemical processes is essential for cell function. Although membrane-bound organelles are well studied in this context, recent work has shown that phase separation is a key contributor to cellular compartmentalization through the formation of liquid-like membraneless organelles (MLOs). In this Minireview, the key mechanistic concepts that underlie MLO dynamics and function are first briefly discussed, including the relevant noncovalent interaction chemistry and polymer physical chemistry. Next, a few examples of MLOs and relevant proteins are given, along with their functions, which highlight the relevance of the above concepts. The developing area of active matter and non-equilibrium systems, which can give rise to unexpected effects in fluctuating cellular conditions, are also discussed. Finally, our thoughts for emerging and future directions in the field are discussed, including in vitro and in vivo studies of MLO physical chemistry and function. 相似文献
Low-frequency (LF) (20 Hz to 10 MHz) field response investigations are reported in TSiKN65F series-based chiral liquid crystal compound, C-10, viz., 1-[3?-nitro-4?-S-(2-decyloxy)phenyl]phenyl-4-(1,1,1,3,5,5,5-heptamethyltrisiloxydecyloxy)-3-Fluorobenzoate. Molecular frame with 10-methylene units and a chiral center on one end is connected to the core with 3-phenyl rings. Other end of core connected to biforked trisiloxy chain to promote de Vries phase. Isotropic-smectic-A and smectic-A-smectic-C*deVr transitions are determined by capacitance study. DC field reversal and polarized optical microscopy textures confirmed occurrence of SmC*deVr phase below SmA. Hysteresis is observed in SmC*deVr. Tilt order parameter growth estimated in SmC*deVr phase through β equal to 0.673 agrees with mean field prediction. Relaxation behavior in kilo Hertz region is explained through longitudinal dipole moment μl reorientation. Dynamics studied through LF dielectric relaxation infers dominance of order director fluctuations at few kilohertz. Higher activation energy in de Vries phase infers greater degrees of freedom and additional constraints. Loss ε″(T) exhibited anomalous trend at SmA-to-SmC*deVr interface. Temperature variation of tilt θ(T) is estimated from loss. Loss in de Vries phase gets suppressed by field to infer collective response. Curie–Weiss behavior by γ-exponent ~0.03 infers weaker ferroelectric response in SmC*deVr phase. Loss variation ε″(T) addressed by perturbed bookshelf model reveals marginal layer contraction by <1% in SmC*deVr phase. Estimates of layer shrinkage through R- and f-parameters in SmC*deVr phase confirm the de Vries behavior. 相似文献
Thermodynamically favored simultaneous coordination of Pt(ii) corners with aza- and carboxylate ligands yields tricomponent coordination complexes with sophisticated structures and functions, which require careful structural characterization to paint accurate depiction of their structure–function relationships. Previous reports claimed that heteroleptic coordination of cis-(Et3P)2PtII with tetrapyridyl porphyrins (M′TPP, M′ = Zn or H2) and dicarboxylate ligands (XDC) yielded 3D tetragonal prisms containing two horizontal M′TPP faces and four vertical XDC pillars connected by eight Pt(ii) corners, even though such structures were not supported by their 1H NMR data. Through extensive X-ray crystallographic and NMR studies, herein, we demonstrate that self-assembly of cis-(Et3P)2PtII, M′TPP, and four different XDC linkers having varied lengths and rigidities actually yields bow-tie (⋈)-shaped 2D [{cis-(Et3P)2Pt}4(M′TPP) (XDC)2]4+ complexes featuring a M′TPP core and two parallel XDC linkers connected by four heteroleptic PtII corners instead of 3D prisms. This happened because (i) irrespective of their length (∼7–11 Å) and rigidity, the XDC linkers intramolecularly bridged two adjacent pyridyl-N atoms of a M′TPP core via PtII corners instead of connecting two cofacial M′TPP ligands and (ii) bow-tie complexes are entropically favored over prisms. The electron-rich ZnTPP core of a representative bow-tie complex selectively formed a charge-transfer complex with highly π-acidic 1,4,5,8,9,12-hexaazatriphenylene-2,3,6,7,10,11-heaxacarbonitrile but not with a π-donor such as pyrene. Thus, this work not only produced novel M′TPP-based bow-tie complexes and demonstrated their selective π-acid recognition capability, but also underscored the importance of proper structural characterization of supramolecular assemblies to ensure accurate depiction of their structure–property relationships.Thermodynamically favored heteroleptic coordination of Pt(ii) corners with tetrapyridyl porphyrins and dicarboxylate ligands produces 2D bow-tie shaped complexes instead of previously mischaracterized 3D tetragonal prisms.相似文献
Quantum tunneling in one spatial dimension in the presence of time-dependent potentials is investigated theoretically. First, a general multichannel formulation of the problem is given for harmonic time-dependence. The case of an oscillatory delta-function potential of constant strength is discussed at length and specific numerical calculations are presented for the reflection and transmission coefficients. Then other exactly solvable time-dependent potentials are obtained by carrying out successive unitary transformations. As an example of this class, a delta-function potential with time-dependent strength and boundary conditions is studied. Finally tunneling time-delay for time-dependent potentials is formulated in the multichannel situation, and also the concept of first passage time for the decay of a wave packet confined to one well of a double well potential is generalized for the case of time-dependent barrier and boundary conditions. 相似文献
Dendritic polymers constitute an intriguing class of macromolecules that offer tremendous potential in designing new materaisl for applications in areas such as catalysis and small molecule loading and delivery. Synthesis of a variety of dendritic polymers using a simple and highly versatile synthetic methodology has enabled us to carry out a detailed investigation of dendritic effects in transition metal catalyzed organic transformations. Small dye molecules such as p-nitroaninline and DR1 could be loaded into the intrinsic cavities of the backbone of 3,5-dihydroxybenzyl alcohol based dendrimers, leading to a change in physical properties of both the dye and the dendrimer. We are also exploring the use of dendrimers as templates to prepare network carriers containing cavities of predetermined size and disposition. 相似文献