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181.
An analytical method for determining bromate in drinking water was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The (18)O-enriched bromate was used as an internal standard. The limit of quantification (LOQ) of bromate was 0.2 μg/L. The peak of bromate was separated from those of coexisting ions (i.e., chloride, nitrate and sulfate). The relative and absolute recoveries of bromate in two drinking water samples and in a synthesized ion solution (100 mg/L chloride, 10 mg N/L nitrate, and 100 mg/L sulfate) were 99-105 and 94-105%, respectively. Bromate concentrations in 11 drinking water samples determined by LC-MS/MS were <0.2-2.3 μg/L. The results of the present study indicated that the proposed method was suitable for determining bromate concentrations in drinking water without sample pretreatment. 相似文献
182.
Fuse S Okada K Iijima Y Munakata A Machida K Takahashi T Takagi M Shin-ya K Doi T 《Organic & biomolecular chemistry》2011,9(10):3825-3833
The total synthesis of a natural product HDAC inhibitor, spiruchostatin B, was successfully achieved. A 5-step synthesis that included an asymmetric aldol reaction was carried out in an automated synthesizer to provide an (E)-(S)-3-hydroxy-7-thio-4-heptenoic acid segment that is the crucial structure of cysteine-containing, depsipeptidic natural products such as spiruchostatins, FK228, FR901375, and largazole for their inhibitory activity against HDACs. 相似文献
183.
Nakatake H Ekimoto H Aso M Ogawa A Yamaguchi A Suemune H 《Chemical & pharmaceutical bulletin》2011,59(6):710-713
Bisphosphonates have high affinity for hydroxyapatite (HA), which is abundantly present in bone. Also, platinum complexes are known that have a wide spectrum of antitumor activities. The conjugate of bisphosphonate and a platinum complex might have HA affinity and antitumor activity, and become a drug for metastatic bone tumor. In this study, the authors synthesized platinum complexes that had dialkyl bisphosphonic acid as a ligand, and evaluated the possibility of the synthesized complexes as a drug for metastatic bone tumor. The synthesized dialkyl bisphosphonate platinum(II) complex was characterized, and its stability in an aqueous solution was also confirmed. The synthesized platinum complex showed higher HA affinity than other platinum complexes such as cisplatin and carboplatin in an experiment of adsorption to HA. In vitro, the platinum complex showed tumor growth inhibitory effect stronger than or equal to cisplatin, which is the most commonly used antitumor agent. Moreover, the platinum complex showed a bone absorption inhibitory effect on the osteoclast. These results suggest potential of dialkyl bisphosphonate platinum(II) complexes as a drug for metastatic bone tumor. 相似文献
184.
We examined the intradermal delivery of a hydrophilic polyphenol chlorogenic acid by in vitro study using excised guinea pig dorsal skin and Yucatan micropig skin. Skin accumulation as well as the solubility of chlorogenic acid in aqueous vehicles was much greater than for other polyphenols such as quercetin and genistein. However, since enhancement of skin delivery seemed to be necessary to exhibit its protective effects against oxidative damage of skin, we examined the effects of microemulsions as vehicles. Using microemulsions consisting of 150 mM NaCl solution, isopropyl myristate, polyoxyethylene sorbitan monooleate (Tween 80) and ethanol, skin accumulation as well as solubility of chlorogenic acid further increased. Enhancement effect of an oil-in-water (o/w-type) microemulsion was greater than that of a water-in-oil (w/o-type) microemulsion possibly due to the greater increase in solubility. This finding was quite different from previous findings on relatively hydrophobic polyphenols such as quercetin and genistein. Pretreatment of guinea pig dorsal skin with chlorogenic acid containing microemulsion gel prevented erythema formation induced by UV irradiation. These findings indicate the potential use of hydrophilic chlorogenic acid with o/w-type microemulsion as a vehicle to protect skin against UV-induced oxidative damage. 相似文献
185.
K. Yasutake H. Kakiuchi H. Ohmi K. Yoshii Y. Mori 《Applied Physics A: Materials Science & Processing》2005,81(6):1139-1144
Epitaxial Si growth at low temperatures (500–800 °C) by atmospheric pressure plasma chemical vapor deposition has been investigated. Silicon films are deposited on (001) Si wafers using gas mixtures containing He, H2, and SiH4. The effects of deposition parameters (composition of reactive gases, very high frequency (VHF) power, and substrate temperature) on film properties are investigated by reflection high-energy electron diffraction, atomic force microscopy, cross-sectional transmission electron microscopy, and plasma emission spectroscopy. It is found that epitaxial temperature can be reduced by increasing VHF power, and that an optimum range of VHF power exists for Si epitaxy, depending on the substrate temperature and the composition of the reactive gases. The result of the H2 concentration dependence of Hα emission intensity, shows that hydrogen atoms generated in the atmospheric pressure plasma play an important role in Si epitaxial growth. Under the optimized growth conditions, defect-free epitaxial Si films (as observed by transmission electron microscopy) with excellent surface flatness are grown at 500 °C with an average growth rate of approximately 0.25 μm/min. PACS 81.05.Cy; 81.15.Gh; 68.55.Jk 相似文献
186.
Crosslinked materials derived from poly(lactide) (PLA) have been produced by radiation modification in the presence of a suitable crosslinker (triallyl isocyanurate) (TAIC). The crosslinking structure introduced in PLA films has not only much improved the heat stability but also their mechanical properties. The properties of crosslinked samples are governed by crosslinking density and these improvement seemed to increase with radiation dose. This implied that the three dimensional networks have been introduced in material by radiation and the crosslinking density depended on the structure and length of PLA chains. Biodegradability of PLA was also determined by an enzymatic degradation test and burying in compost at 55 °C. Differing with PLLA, PDLA was insignificantly degraded by proteinase K. The degradation rate of PLA in compost was postponed with the introduction of crosslinks. 相似文献
187.
Kuniko Mitamura Chie Ogasawara Asami Shiozawa Erika Terayama Kazutake Shimada 《Analytical sciences》2005,21(10):1241-1244
A determination method for steroid 5alpha-reductase activity using liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS) in the positive-ion mode has been developed. The rat prostatic enzyme source was used and the enzymatically formed 5alpha-dihydrotestosterone and 5a-androstane-3alpha,17beta-diol were determined by LC/APCI-MS using absolute calibration curve method. The sum of the formed products was used as a measurement of the enzyme activity. This method was applied to kinetic study of this enzyme and inhibitory experiments using Finasteride as a model inhibitor. 相似文献
188.
H. Yuki J. Kasagi A. G. Lipson T. Ohtsuki T. Baba T. Noda B. F. Lyakhov N. Asami 《JETP Letters》1998,68(11):823-829
Yields of protons emitted in the D+D reaction in Pd, Au/Pd/PdO, Ti, and Au foils are measured by a d
E-E counter telescope for bombarding energies between 2.5 and 10 keV. The experimental yields are compared with those predicted
from a parametrization of the cross section and stopping power at higher energies. It is found that for Ti and Au target the
enhancement of the D(d,p)T reaction is similar to that observed with a deuterium gas target (several tens of eV). The dependence of the yields on the
bombarding energy corresponds well to the screening potential parameters U
s=250±15 eV for Pd and 601 ±23 eV for Au/Pd/PdO. Possible models of the enhancement obtained are discussed.
Pis’ma Zh. éksp. Teor. Fiz. 68, No. 11, 785–790 (10 December 1998)
Published in English in the original Russian journal. Edited by Steve Torstveit. 相似文献
189.
Asymmetric oxidative coupling polymerization affording polynaphthylene with 1,1′-bi-2-naphthol units
Shigeki Habaue Hiroharu Ajiro Yasuhiro Yoshii Tetsuya Hirasa 《Journal of polymer science. Part A, Polymer chemistry》2004,42(18):4528-4534
The oxidative coupling polymerizations of racemic-, (R)-, and (S)-2,2′-dimethoxymethoxy-1,1′-binaphthalene-3,3′-diols were carried out with a copper catalyst with various ligands, such as N,N,N′,N′-tetramethylethylenediamine (TMEDA), (S)-(+)-1-(2-pyrrolidinylmethyl)pyrrolidine, (−)-sparteine, and (S)-(−)-2,2′-isopropylidenebis(4-phenyl-2-oxazoline) [(−)-Phbox], under an O2 atmosphere. For example, a 10/1 (v/v) MeOH · H2O-insoluble polymer with a number-average molecular weight of 3.8 × 103, from a polymerization with CuCl–TMEDA followed by acetylation of the hydroxyl groups, was obtained in a 71% yield. Polymerization with (−)-Phbox proceeded in an S-selective manner to give a polymer with the highest negative specific rotation from the (S)-monomer. The obtained polymer was successfully converted into a polymer with the optically pure 1,1′-bi-2-naphthol unit based on the original monomer structure, which could be used as a polymeric chiral auxiliary and showed catalytic activity for the asymmetric diethylzinc addition reaction to aldehydes. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 4528–4534, 2004 相似文献
190.
A. G. Lipson G. H. Miley V. A. Kuznetsov E. I. Saunin N. Asami 《Physics of the Solid State》2003,45(8):1409-1414
The effects of a significant decrease in the sputtering rate and of the symmetrical separation of the isotope pairs 108Pd-105Pd and 110Pd-104Pd at depths up to 500 Å are experimentally detected in Pd specimens saturated with deuterium during electrolysis (i.e., having a high concentration of internal stresses). These effects are shown to be qualitatively explained using the concepts of isotope separation by centrifugation and diffusion with allowance for defects and mechanical stresses that appear in the near-surface Pd layer during deuterium penetration. 相似文献