Visible light photoredox catalysis with N-hydroxyphthalimide for [4+2] cyclization between N-methylanilines and maleimides

An efficient [4+2] cyclization of N-methylanilines with maleimides to afford tetrahydroquinolines using N-hydroxyphthalimide as a metal-free and cheap organophotoredox catalyst is reported. The protocol involves C(sp³)H activation of N-methylanilines for the formation of α-amino radical without an oxidant at room temperature. The present method describes an easy preparation of tricyclic heterocycles in good to excellent yields under mild reaction conditions.     

Efficient copper-catalyzed Sonogashira coupling reactions and simulation studies

A practical copper-catalyzed I-substitutions of alkyl-2-iodobenzoates with alkynes have been developed using Cu powder as a catalyst under solvent, cocatalyst, and base-free conditions. This reaction system is new, facile, efficient, and economical that gives Sonogashira coupling products in excellent yields (up to 97%). The coupled products (A–J) were characterized by CHNS, ¹H NMR, and ¹³C NMR and are found soluble in ethyl acetate and dichloromethane. In addition, simulation studies of A–J were performed with aspulvinone dimethylallyltransferase enzyme and observe good binding affinity. The reported compounds may act as anti-cizmatics, anti-fobic in future and also have the inhibition of aspulvinone dimethylallyltransferase properties to control Alzheimer’s, Schizophrenia, etc. diseases.     

Quorum sensing regulates electric current generation of Pseudomonas aeruginosa PA14 in bioelectrochemical systems

Here, we show that quorum sensing (QS) modulates the current generation of the anode-respiring bacterium Pseudomonas aeruginosa because it controls the production of phenazines, which mediate the electron transfer to the anode. The current generation by a wildtype (WT) strain P. aeruginosa PA14 and the GacS/GacA protein-regulatory mutant retS was investigated under different environmental conditions. The retS mutant generated significantly higher current (45-fold) than the WT under anaerobic conditions. Anaerobic current generation by the WT was 28-fold higher with extraneously supplied lactones (a QS-signaling molecule). Compared to anaerobic conditions, the WT with some oxygen (microaerobic conditions) exhibited enhanced phenazine production (39-fold) and current levels (48-fold). Iron-rich medium and microaerobic conditions had a negative impact on current generation by retS. All these results were directly linked to QS activity in P. aeruginosa, thus, demonstrating the importance of this bacterial communication system for current generation in BESs. We also show that BESs represent a new tool for real-time investigation of phenazine-related QS activity.     

Measurement of electron spin lifetime and optical orientation efficiency in germanium using electrical detection of radio frequency modulated spin polarization

We propose and demonstrate a technique for electrical detection of polarized spins in semiconductors in zero applied magnetic fields. Spin polarization is generated by optical injection using circularly polarized light which is modulated rapidly using an electro-optic cell. The modulated spin polarization generates a weak time-varying magnetic field which is detected by a sensitive radio-frequency coil. Using a calibrated pickup coil and amplification electronics, clear signals were obtained for bulk GaAs and Ge samples from which an optical spin orientation efficiency of 4.8% could be determined for Ge at 1342 nm excitation wavelength. In the presence of a small external magnetic field, the signal decayed according to the Hanle effect, from which a spin lifetime of 4.6±1.0 ns for electrons in bulk Ge at 127 K was extracted.     

Combinatorial Markov chains on linear extensions

We consider generalizations of Schützenberger’s promotion operator on the set $\mathcal{L}$ of linear extensions of a finite poset of size n. This gives rise to a strongly connected graph on $\mathcal{L}$ . By assigning weights to the edges of the graph in two different ways, we study two Markov chains, both of which are irreducible. The stationary state of one gives rise to the uniform distribution, whereas the weights of the stationary state of the other have a nice product formula. This generalizes results by Hendricks on the Tsetlin library, which corresponds to the case when the poset is the anti-chain and hence $\mathcal{L}=S_{n}$ is the full symmetric group. We also provide explicit eigenvalues of the transition matrix in general when the poset is a rooted forest. This is shown by proving that the associated monoid is $\mathcal {R}$ -trivial and then using Steinberg’s extension of Brown’s theory for Markov chains on left regular bands to $\mathcal {R}$ -trivial monoids.     

HPTLC Method for Analysis of Piperine in Fruits of Piper Species

JPC – Journal of Planar Chromatography – Modern TLC - Piperine, an alkaloid with diverse biological activity commonly occurring in fruits of Piper sp., has high commercial, economical,...