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71.
Sokolov MN Gushchin AL Abramov PA Virovets AV Peresypkina EV Fedin VP 《Inorganic chemistry》2007,46(11):4677-4682
New ternary and quaternary molybdenum cluster chalcohalides were obtained by high-temperature reactions between Mo, chalcogens, and halogens in evacuated ampules. The crystal structures of [Mo3Se7(TeBr3)Br2]2[Te2Br10] (1), [Mo3Se7(TeI3)I2]I (2), and [Mo3Te7(TeI3)3]2(I)(TeI3) (3) were determined by single-crystal X-ray diffraction. The structures of 1 and 2 consist of positively charged zigzag chains infinity1 [Mo3Se7(TeX3)X4/2] (X=Br, I), with Te2Br102- and I-, respectively, as counterions. The TeI3- and TeBr3- ions function as bidentate ligands in 1 and 2. In 3, TeI3- is not coordinated to the metal but acts as a counterion to the [Mo3Te7(TeI3)3]+ cluster cation. 相似文献
72.
Evdokimov NM Kireev AS Yakovenko AA Antipin MY Magedov IV Kornienko A 《The Journal of organic chemistry》2007,72(9):3443-3453
Heterocyclic privileged medicinal scaffolds involving pyridine, 1,4-dihydropyridine, chromeno[2,3-b]pyridine, and dihydro-1,4-dithiepine frameworks are prepared via a single-step multicomponent reaction of structurally diverse aldehydes with various thiols and malononitrile. Mechanistic studies of the synthetic pathway leading to pyridines reveal that 1,4-dihydropyridines undergo oxidation by the intermediate Knoevenagel adducts rather than by air oxygen. The use of o,o'-disubstituted aromatic aldehydes leads to the corresponding 1,4-dihydropyridines, whereas salicylic aldehydes result in chromeno[2,3-b]pyridines. Reactions of ethanedithiol as a thiol component produce dimeric pyridines with sterically unencumbered aldehydes, while o,o'-disubstituted aromatic aldehydes give dihydro-1,4-dithiepines. Thus, depending on the aldehyde and thiol types, diverse libraries of medicinally relevant compounds can be prepared by a simple one-step process involving no chromatography. 相似文献
73.
We use a Flory-Huggins type approach and the random phase approximation (RPA) to describe a microphase separation in the mixture of ionic and nonionic liquids. The mixture is modeled as a "three-component" system including anions, cations, and neutral molecules. Each ion is considered to consist of a charged group surrounded by a neutral "bulky" shell. The shells of the anion and cation are assumed to have different affinities to the neutral molecules. We show that, if the difference of the Flory-Huggins parameters describing affinities of the anions and cations to the neutral molecules is higher than a certain value, the microphase separation can occur. The physical reason for the separation is a delicate balance between the short-range segregating interactions and the long-range Coulomb interactions. 相似文献
74.
Stela Georgieva Artem Bezfamilnyi Anton Georgiev Marian Varbanov 《Molecules (Basel, Switzerland)》2021,26(19)
Herein, the spectral and electrochemical characterizations of three different substituted N-phthalimide azo-azomethine (NAA) dyes (L) containing an o-hydroxy group and their NAA-M(II) chelates [M(II): Cu, Ni, Co, Pb] were reported by using UV–Vis and fluorescence spectroscopy and potentiometric and voltamperometric techniques. The pK value of the dyes as well as the stoichiometry and stability of the NAA-metal chelates were studied, and the stoichiometry was found to be mostly 1:2 (ML2) with high complex stability constant values. The sensor activity of N-phthalimide azo-azomethine derivatives toward pH and metal ions has been also investigated and tested for indicator application in acid–base analysis and detection of Cu(II) ions in real samples of surface river water using voltamperometric detection. The results showed that one of the ligands possesses the highest electrochemical response upon binding to copper ions and could be successfully used in the analysis of copper in water at a concentration range of the analyte from 3.7 × 10−7 to 5.0 × 10−6 mol L−1, with analytical characteristics of the method being Sr = 1.5%, LOD = 3.58 µg L−1 and LOQ =11.9 µg L−1 相似文献
75.
It is shown that if X is an n – dimensional subspace of Lp, 0 < p < 1, then there exists a subspace Y of 𝓁Np such that d(X, Y) ≤ 1 + ε and N ≤ C(ε, p)n(log n)3. 相似文献
76.
Francesco Gentile Michael Fernandez Fuqiang Ban Anh-Tien Ton Hazem Mslati Carl F. Perez Eric Leblanc Jean Charle Yaacoub James Gleave Abraham Stern Bill Wong Franois Jean Natalie Strynadka Artem Cherkasov 《Chemical science》2021,12(48):15960
Recent explosive growth of ‘make-on-demand’ chemical libraries brought unprecedented opportunities but also significant challenges to the field of computer-aided drug discovery. To address this expansion of the accessible chemical universe, molecular docking needs to accurately rank billions of chemical structures, calling for the development of automated hit-selecting protocols to minimize human intervention and error. Herein, we report the development of an artificial intelligence-driven virtual screening pipeline that utilizes Deep Docking with Autodock GPU, Glide SP, FRED, ICM and QuickVina2 programs to screen 40 billion molecules against SARS-CoV-2 main protease (Mpro). This campaign returned a significant number of experimentally confirmed inhibitors of Mpro enzyme, and also enabled to benchmark the performance of twenty-eight hit-selecting strategies of various degrees of stringency and automation. These findings provide new starting scaffolds for hit-to-lead optimization campaigns against Mpro and encourage the development of fully automated end-to-end drug discovery protocols integrating machine learning and human expertise.Deep learning-accelerated docking coupled with computational hit selection strategies enable the identification of inhibitors for the SARS-CoV-2 main protease from a chemical library of 40 billion small molecules. 相似文献
77.
The results of ultrasonic action to the substances have been presented. It is examined, the correlation between the electrical
parameters of ultrasonic equipment and acoustic performances of the ultrasonic field in treating the medium, the efficiency
of ultrasonic technological facility, and the peculiarities of oscillations introduced into the load under cavitation development.
The correlation between the acoustic powers of oscillations securing the needed level of cavitation and desired technological
effect, and the electrical parameters of the ultrasonic facility, first of all, the power, is established. The peculiarities
of cavitation development in liquids with different physical-chemical properties (including the molten low-melting metals)
have been studied, and the acoustic power of oscillations introduced into the load under input variation of electric power
to the generator has been also estimated. 相似文献
78.
Sergey P. Gromov Svetlana N. Dmitrieva Artem I. Vedernikov Nikolay A. Kurchavov Lyudmila G. Kuz'mina Yuri A. Strelenko Michael V. Alfimov Judith A. K. Howard 《Journal of Physical Organic Chemistry》2009,22(9):823-833
An improved method for the synthesis of formyl derivatives of N‐methylbenzoazacrown ethers is proposed. They are prepared in up to 68% yields over fewer steps and with a much shorter time required for the last step. The stability constants of complexes formed by N‐methylbenzoazacrown ethers and their structural analogs with alkali metal, alkaline‐earth metal and ammonium cations were determined by 1H NMR titration in CD3CN. High stability of complexes of N‐methyl derivatives of benzoazacrown ethers is demonstrated, comparable with or even exceeding the stability of benzocrown‐ether complexes and markedly exceeding the stability of complexes of phenylazacrown ethers with the same macrocycle size. The structures of azacrown ethers and their complexes with Ba(ClO4)2 were studied by X‐ray diffraction. A high degree of pre‐organization of N‐methylbenzoazacrown ethers toward the formation of complexes with metal and ammonium cations was noted, which is due to the clear‐cut pyramidal geometry of the nitrogen atom and the orientation of the lone electron pairs (LEPs) of most heteroatoms towards the centre of the macroheterocycle. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
79.
We study the relationship between two Hecke theta series, the Dedekind function, and the Gauss hypergeometric function. The main result of the present paper is given by formulas for the representation of the theta series in the form of compositions of the squared Dedekind function, a power of the absolute invariant, and canonical integrals of the second-order hypergeometric differential equation with special values of the three parameters. The proofs of these representations are based on the properties of the matrix transforming the canonical integrals of the Gauss equation in a neighborhood of zero into canonical integrals of the same equation in a neighborhood of unity. 相似文献
80.
The two concepts of micelle formation (pseudo-phase and mass-action) could be the basis of retention models in micellar liquid chromatography (MLC). The separation of 4-hydroxybenzoic acid esters and seven polyaromatic hydrocarbons were performed to study the repeatability of retention factor in MLC. The full two factor experimental design was used for studying the dependence of retention factor variance on mobile phase composition (sodium dodecylsulfate, 1-butanol). The experimentally observed heteroscedasticity and perturbations after linearization were taken into account by using statistical weights obtained on the basis of errors propagation law and the modeling of retention by non-weighted and weighted least squares method was performed. The mechanistical retention models based on pseudo-phase and mass-action concepts of micelle formation were compared by fitting quality and prediction capability and high robustness of bilogarithmic dependence was observed. The significance of retention factor heteroscedasticity for retention hydrophobicity relationships was shown. 相似文献