Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions

Background  

Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C.     

Theoretical analysis of a simple yet efficient portable magnetic separator design for separation of magnetic nano/micro-carriers from human blood flow

A technology that could physically remove substances from the blood such as biological, chemical, or radiological toxins could dramatically improve treatment of disease. One method in development proposes to use magnetic-polymer spheres to selectively bind toxins and remove them by magnetic filtration. Although magnetic filtration is a developed technology, the clinical boundary conditions described here require a new filter design. We investigated the removal of toxin-bound magnetic carriers from the blood stream using 2-D FEMLAB simulations. The magnetic separator consisted of a permanent magnet with parallel ferromagnetic prisms on the faces and in contact with a straight tube carrying the magnetic-polymer spheres in suspension. We varied the following parameters: blood flow velocity, the size, and number of ferromagnetic prisms, and the ferromagnetic material in both prisms and magnets. The capture efficiency reached maximum values when the depth of the prisms equaled the diameter of the tubing and the saturation magnetization of the prism material equaled twice that of the magnet. With this design a piece of 2 mm (diameter) tube carrying the fluid resulted in 95% capture of 2.0 μm magnetic-polymer spheres at 10 cm/s flow velocity.     

Ergänzung zu “Über rationale Darstellungen von Kettengeometrien als projektive Varietäten”

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Unusual peak defocusing in capillary GC on hexakis(2,6-diO-pentyl-3-O-acetyl)-α-cyclodextrin stationary phase

An unusual peak defocusing effect influencing chromatographic performance over a limited range of elution temperatures is described for hexakis(2,6-di-O-pentyl-3-O-acetyl)-α-cyclodextrin stationary phase. Since this phenomenon is likely to be dependent on minor details of the cyclodextrin molecule, full assignment of the ¹H- and ¹³C-NMR-spectra are given.     

A Dual‐Phase Ceramic Membrane with Extremely High H2 Permeation Flux Prepared by Autoseparation of a Ceramic Precursor

A novel concept for the preparation of multiphase composite ceramics based on demixing of a single ceramic precursor has been developed and used for the synthesis of a dual‐phase H₂‐permeable ceramic membrane. The precursor BaCe_0.5Fe_0.5O_3?δ decomposes on calcination at 1370 °C for 10 h into two thermodynamically stable oxides with perovskite structures: the cerium‐rich oxide BaCe_0.85Fe_0.15O_3?δ (BCF8515) and the iron‐rich oxide BaCe_0.15Fe_0.85O_3?δ (BCF1585), 50 mol % each. In the resulting dual‐phase material, the orthorhombic perovskite BCF8515 acts as the main proton conductor and the cubic perovskite BCF1585 as the main electron conductor. The dual‐phase membrane shows an extremely high H₂ permeation flux of 0.76 mL min^?1 cm^?2 at 950 °C with 1.0 mm thickness. This auto‐demixing concept should be applicable to the synthesis of other ionic‐electronic conducting ceramics.