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131.
A transition from regular to chaotic behaviour in the dynamics of a classical Henon-Heiles oscillator in the presence of an
external field is shown to have a similar quantum signature when studied using the pertaining phase portraits and the associated
Kolmogorov-Sinai-Lyapunov entropies obtained through the corresponding Bohmian trajectories. 相似文献
132.
Poonam Giri Nirmal Patel Vipul Joshi Shyamkumar Giri Nuggehally R. Srinivas 《Biomedical chromatography : BMC》2019,33(3)
Bioanalysis plays a key role during the drug discovery process to generate the pharmacokinetic data to facilitate unbiased evaluation of leads, optimized leads and drug candidates. Such pharmacokinetic data are used to enable key decisions in the drug discovery process. The aim of the work is to put forward a new strategy of performing the incurred sample reanalysis for select small molecule novel chemical entities at different stages of drug discovery prior to candidate selection. Three discovery programs representing hits, leads and optimized lead candidates were selected for the incurred sample reanalysis (ISR) analysis. From each discovery program, two novel chemical entities were selected for the ISR analysis. The time points considered for ISR generally varied among the programs; however, samples coinciding with drug absorption, distribution and elimination were considered in the ISR assessment. With the exception of a single ISR value that gave a high deviation (about 63%), the observed ISR values supported the discovery bioanalytical assays. While the individual bioanalytical laboratory can draw an algorithm for selecting novel chemical entities and fixing the acceptance criteria for the ISR data, it is proposed that the percentage difference between ISR vs. original concentration for 67% of the repeat samples is contained within ±30% for discovery bioanalysis. 相似文献
133.
Dr. Sara Morales-Reina Dr. Chandan Giri Maxime Leclercq Dr. Sonia Vela-Gallego Isabel de la Torre Dr. José R. Castón Dr. Mathieu Surin Dr. Andrés de la Escosura 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(5):1082-1090
One of the major goals in systems chemistry is to create molecular assemblies with emergent properties that are characteristic of life. An interesting approach toward this goal is based on merging different biological building blocks into synthetic systems with properties arising from the combination of their molecular components. The covalent linkage of nucleic acids (or their constituents: nucleotides, nucleosides and nucleobases) with lipids in the same hybrid molecule leads, for example, to the so-called nucleolipids. Herein, we describe nucleolipids with a very short sequence of two nucleobases per lipid, which, in combination with hydrophobic effects promoted by the lipophilic chain, allow control of the self-assembly of lipidic amphiphiles to be achieved. The present work describes a spectroscopic and microscopy study of the structural features and dynamic self-assembly of dinucleolipids that contain adenine or thymine moieties, either pure or in mixtures. This approach leads to different self-assembled nanostructures, which include spherical, rectangular and fibrillar assemblies, as a function of the sequence of nucleobases and chiral effects of the nucleolipids involved. We also show evidence that the resulting architectures can encapsulate hydrophobic molecules, revealing their potential as drug delivery vehicles or as compartments to host interesting chemistries in their interior. 相似文献
134.
135.
N. Giri 《Annals of the Institute of Statistical Mathematics》1992,44(2):357-362
Let X: p × 1, Y: p × 1 be independently and normally distributed p-vectors with unknown means 1, 2 and unknown covariance matrices 1, 2 (>0) respectively. We shall show that Pillai's test, which is locally best invariant, is locally minimax for testing H
0: 1=2 against the alternative H
1: % MathType!MTEF!2!1!+-% feaafeart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXafv3ySLgzGmvETj2BSbqefm0B1jxALjhiov2D% aebbfv3ySLgzGueE0jxyaibaiiYdd9qrFfea0dXdf9vqai-hEir8Ve% ea0de9qq-hbrpepeea0db9q8as0-LqLs-Jirpepeea0-as0Fb9pgea% 0lrP0xe9Fve9Fve9qapdbaqaaeGacaGaaiaabeqaamaabaabcaGcba% GaaeiDaiaabkhacaqGOaWaaabmaeaadaaeqaqaaiabgkHiTiaadMea% caGGPaGaaiiiaiabg2da9iaacccacqaHdpWCcaGGGaGaeyOpa4Jaai% iiaiaaicdaaSqaaiaaigdaaeqaniabggHiLdaaleaacaqGYaaabaGa% aeylaiaabgdaa0GaeyyeIuoaaaa!4E3F!\[{\rm{tr(}}\sum\nolimits_{\rm{2}}^{{\rm{ - 1}}} {\sum\nolimits_1 { - I) = \sigma > 0} }\]as 0. However this test is not of type D among G-invariant tests.Research supported by the Canadian N.S.E.R.C. Grant. 相似文献
136.
Kiran Devarasetty Giri Tharikoppula Tailor Sridhar Laxminarayana Eppakayala Mahesh Kyasani Premkumar Arumugam 《合成通讯》2016,46(3):263-274
A series of novel 2-alkylamino and 2, 4-dialkyl amino 6-oxopyrimidin-1(6H)-yl) benzamide derivatives were prepared in good yields from a base-catalyzed ring opening of oxadiazolo[3,2-a]pyrimidin-5-one and evaluated for their antibacterial and cytotoxicity. Most of the compounds exhibited antibacterial activity. In particular, compounds 5b and 5k exhibited considerable antibiotic activity against Klebsiella pneumonia and Bacillus cereus. In addition, compounds 5g and 5i also inhibited the growth of two human tumor cell lines (A549 and H460) at micromolar concentrations. 相似文献
137.
A.K. Giri R. Mohanta M.P. Khanna 《The European Physical Journal C - Particles and Fields》2001,21(1):115-121
We show that the semi-leptonic decay can be used as a source of information for two-pion distribution amplitudes. The connection between these amplitudes and
the B-meson decay width is achieved by the light cone sum rule method. We show the relevant distribution amplitudes and give the
formula for the decay width.
Received: 11 April 2001 / Published online: 19 July 2001 相似文献
138.
The radiative decays of heavy mesons are considered in heavy quark symmetry formalism. Introducing the interpolating fields
for the heavy mesons we obtain the transition matrix element and the corresponding decay widths in the heavy quark symmetry
limits. The Isgur-Wise function present in the expression is determined by ISGW quark model. The results obtained agree reasonably
well with other estimations. 相似文献
139.
Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems 总被引:3,自引:0,他引:3
Trewyn BG Giri S Slowing II Lin VS 《Chemical communications (Cambridge, England)》2007,(31):3236-3245
Recent advancements in controlling the surface properties and particle morphology of the structurally defined mesoporous silica materials with high surface area (>700 m(2) g(-1)) and pore volume (>1 cm(3) g(-1)) have significantly enhanced their biocompatibility. Various methods have been developed for the functionalization of both the internal pore and exterior particle surfaces of these silicates with a tunable pore diameter ranging from 2 to 30 nm and a narrow pore size distribution. Herein, we review the recent research progress on the design of functional mesoporous silica materials for stimuli-responsive controlled release delivery of pharmaceutical drugs, genes, and other chemicals. Furthermore, the recent breakthroughs in utilizing these nanoscale porous materials as sensors for selective detections of various neurotransmitters and biological molecules are summarized. 相似文献
140.
The aim of this article is to put forward the novel concept of porous liquids, or, more precisely, liquids with permanent microporosity. In contrast to the small, transient cavities that exist between the molecules of any liquid (here called "extrinsic" porosity), we suggest that a truly microporous liquid could exist if it had empty pores within the molecules of the liquid ("intrinsic" porosity). By using rigid host molecules with restricted access windows, any unwanted occupation of the pores could be prevented (i.e., the pores could be kept empty and available so that the liquid would be genuinely microporous). The liquid could have permanent, well-defined, empty pores capable of molecular recognition when exposed to other species (e.g., gases etc.). We stress that these phases are not the same as simple solutions of host species, in which any pores would normally be occupied by solvent molecules. In microporous liquids, any solvent molecules, if present, would be deliberately sterically excluded from the host cavities, to leave them readily accessible. Microporous liquids would be of considerable fundamental interest. They could combine properties of microporous solids, such as size- and shape-selective sorption and so forth, with the rapid mass transfer, fluidity and fast kinetics of liquids. Some synthetic approaches to these materials are discussed in this article. Also, whilst the overall concept of microporous liquids is new, literature is described which suggests that some examples have arguably already been reported, even if they have not previously been recognised and characterised in such terms. 相似文献