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71.
An interesting reversible, templated synthesis of unsymmetrical pyridine-ligated Zn complexes has been observed in solution and solid-state phases when Zn(salphen) complexes are reacted with methanol-substituted pyridine substrates. The X-ray molecular structure of an unusual Zn(3) supramolecular assembly is reported, in which the central Zn atom is embedded in a distorted octahedral geometry and each of the single anionic O atoms of the pyridine groups coordinates to a Zn(salphen) unit. 相似文献
72.
We have prepared high-quality assemblies of monodisperse CdSe quantum dots and employed a combination of electrochemical gating and electrical and optical techniques to study orbital occupation in these quantum-dot solids. Electron occupation in localized states is important in some cases and can be unambiguously distinguished from occupation of the nanocrystal eigenstates. In addition, all excitonic transitions show a red-shift in the transition energy, due to the presence of electron charge. We infer that the energy of the S electrons is determined by the quantum-confinement energy and by Coulomb repulsions of the S electron with all other electrons in the assembly. By using a simple electron-repulsion model, we explain observed differences in the electron-addition energy for different samples, the broadening of the electron occupation as a function of electrochemical potential, and the strong dependence of the electron-addition energy on nanocrystal diameter. 相似文献
73.
Naidoo KJ Lopis AS Westra AN Robinson DJ Koch KR 《Journal of the American Chemical Society》2003,125(44):13330-13331
Ion-pair formation between a Na+ cation and the [PtCl62-] anion in methanol is observed from195Pt NMR chemical shift trends as well as from molecular dynamics computer simulations. Free energy of association calculations reveal that contact ion pairs (CIPs) are the most favored configuration in methanol, followed by solvent shared ion pairs (SSHIPs). By contrast, such ion-pair formation is not observed for comparable solutions in water. 相似文献
74.
This paper addresses the issue of structure-preserving discretization of open distributed-parameter systems with Hamiltonian dynamics. Employing the formalism of discrete exterior calculus, we introduce a simplicial Dirac structure as a discrete analogue of the Stokes–Dirac structure and demonstrate that it provides a natural framework for deriving finite-dimensional port-Hamiltonian systems that emulate their infinite-dimensional counterparts. The spatial domain, in the continuous theory represented by a finite-dimensional smooth manifold with boundary, is replaced by a homological manifold-like simplicial complex and its augmented circumcentric dual. The smooth differential forms, in discrete setting, are mirrored by cochains on the primal and dual complexes, while the discrete exterior derivative is defined to be the coboundary operator. This approach of discrete differential geometry, rather than discretizing the partial differential equations, allows to first discretize the underlying Stokes–Dirac structure and then to impose the corresponding finite-dimensional port-Hamiltonian dynamics. In this manner, a number of important intrinsically topological and geometrical properties of the system are preserved. 相似文献
75.
Ellen Verheyen Lise Delain‐Bioton Steffen van der Wal Najim el Morabit Arjan Barendregt Wim E. Hennink Cornelus F. van Nostrum 《Macromolecular bioscience》2010,10(12):1517-1526
An efficient strategy is reported to introduce methacrylamide groups on the lysine residues of a model protein (lysozyme) for immobilization and triggered release from a hydrogel network. A novel spacer unit was designed, containing a disulfide bond, such that the release of the protein can be triggered by reduction. The modified proteins were characterized by MALDI‐TOF MS, titration of free NH2 residues and spectral analysis. The modification reaction is well controlled, and the number of introduced functions can be tailored by changing the reaction conditions. Gel electrophoresis experiments showed that the methacrylamide modified protein can be immobilized in a polyacrylamide hydrogel and subsequently released by reduction of the spacer by which the protein was grafted to the polymeric network.
76.
Escárcega-Bobadilla MV Salassa G Martínez Belmonte M Escudero-Adán EC Kleij AW 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(22):6805-6810
Supramolecular chirality effects have been achieved both for ditopic and monotopic substrates by using a programmable bis-salphen scaffold that incorporates either two or three Zn nuclei. The dinuclear host shows preferential chirogenesis in the presence of ditopic systems, whereas effective chirality transfer to the trinuclear complex is realized through monotopic binding. The mode of binding in the trinuclear host has been investigated through X-ray crystallography, CD measurements, UV/Vis spectroscopy, and DFT analysis. The bis-salphen scaffold holds promise for the development of substrate-specific host systems useful for determination of the absolute configuration of various types of organic molecules. 相似文献
77.
Houtepen AJ Koole R Vanmaekelbergh D Meeldijk J Hickey SG 《Journal of the American Chemical Society》2006,128(21):6792-6793
Monodisperse spherical, star-shaped, and octahedral PbSe nanocrystals were synthesized via a hot injection method. We show that the shape and size of the colloidal PbSe nanocrystals are determined by the concentration of acetate and that only acetate-free reaction mixtures result in spherical nanocrystals. The presence of acetate leads to efficient oriented attachment of smaller PbSe nanoparticles along the 100 crystal axis. Comparing different synthesis procedures from the recent literature with our observations, we propose that the acetate, naturally present in insufficiently dried reaction mixtures, is responsible for many of the PbSe crystal shapes reported in the literature. In addition we show that it is possible to synthesize these star-shaped nanocrystals so monodisperse that they form ordered monolayers with crystal alignment. 相似文献
78.
A novel approach for the selection of step parameters as reaction coordinates in enhanced sampling simulations of DNA is presented. The method uses three atoms per base and does not require coordinate overlays or idealized base pairs. This allowed for a highly efficient implementation of the calculation of all step parameters and their Cartesian derivatives in molecular dynamics simulations. Good correlation between the calculated and actual twist, roll, tilt, shift, and slide parameters is obtained, while the correlation with rise is modest. The method is illustrated by its application to the methylated and unmethylated 5′‐CATGTGACGTCACATG‐3′ double stranded DNA sequence. One‐dimensional umbrella simulations indicate that the flexibility of the central CG step is only marginally affected by methylation. © 2014 Wiley Periodicals, Inc. 相似文献
79.
Mónica Ávila Arjan Floris Steven Staal Ángel Ríos Jan Eijkel Albert van den Berg 《Electrophoresis》2013,34(20-21):2956-2961
A point‐of‐care device for the determination of elevated creatinine levels in blood is reported. This device potentially offers a new and simple clinical regime for the determination of creatinine that will give huge time savings and removal of several steps of determination. The test employs a disposable prefilled microchip and the handheld Medimate Multireader®. By optimizing the analytical conditions it was found that the LOD of the proposed method was 87 μM creatinine, close to the normal human serum levels that are in the range of 60 to 100 μM. A statistical analysis of the residual shows a normal distribution, indicating the absence of systematic errors in the proposed method. The test can be used to distinguish patients with renal insufficiency (creatinine levels >100 μM) from healthy persons. Long‐term monitoring could furthermore distinguish between acute renal failure and chronic kidney disease by the rate of creatinine concentration rise. 相似文献
80.
An umbrella sampling method for the calculation of free energies for helical transitions is presented. The method biases structures toward helices of a desired radius and pitch. Although computationally complex, the method has negligible overhead in actual applications. To illustrate the method, calculations of the helical free energy landscape of several peptides are presented for both the CHARMM and the AMBER force fields. © 2012 Wiley Periodicals, Inc. 相似文献