Formulation of a freeze-dried kit for 188Re-MAG3 and its quality control

The synthesis of ¹⁸⁸Re-MAG₃ is described using ¹⁸⁸Re, which was obtained from the alumina based ¹⁸⁸W/¹⁸⁸Re generator. Dependence of the radiolabeling yields of ¹⁸⁸Re-MAG₃ on reducing agent concentration, Bz-MAG₃ concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of ¹⁸⁸Re-MAG₃ was 98%. TLC and HPLC techniques were employed to monitor the different species formed. Biodistribution study of ¹⁸⁸Re-MAG₃ was carried out in rats and compared with behavior of ^99mTc-MAG₃.     

Reactions of SF6 with organotitanium and organozirconium complexes: the "inert" SF6 as a reactive fluorinating agent

The normally remarkably inert SF6 has been found to be quite reactive toward low valent organometallic compounds, under conditions in which usually powerful fluorinating agents may be less reactive. Reaction of SF6 with Ti[1,3-C5H3(t-Bu)2](6,6-dmch)(PMe3), for example, leads to {Ti[1,3-C5H3(t-Bu)2]F2}4 (dmch = dimethylcyclohexadienyl), whose structure is based on a cube of fluoride ions with the ligated titanium centers situated above four coplanar face centers.     

Mobility–diffusivity relationship for heavily doped organic semiconductors

The relationship between the diffusivity D _n and the mobility μ _n of chemically doped organic n-type semiconductors exhibiting a disordered band structure is presented. These semiconductors have a Gaussian-type density of states. So, calculations have been performed to elucidate the dependence of D _n /μ _n on the various parameters of this Gaussian density of states. Y. Roichman and N. Tessler (Appl. Phys. Lett. 80:1948, 2002), and subsequently Peng et al. (Appl. Phys. A 86:225, 2007), conducted numerical simulations to study this diffusivity–mobility relationship in organic semiconductors. However, almost all other previous studies of the diffusivity–mobility relationship for inorganic semiconductors are based on Fermi–Dirac integrals. An analytical formulation has therefore been developed for the diffusivity/mobility relationship for organic semiconductors based on Fermi–Dirac integrals. The D _n /μ _n relationship is general enough to be applicable to both non-degenerate and degenerate organic semiconductors. It may be an important tool to study electrical transport in these semiconductors.     

On structure-preserving connections

In this paper we find the formula of connections under which an almost complex structure is covariantly constant. These types of connections on anti-Kähler–Codazzi manifolds are described. Also, twin metric-preserving connections are analyzed for quasi-Kähler manifolds. Finally, anti-Hermitian Chern connections are investigated.     

A New Synthetic Approach to Functionalized Bicyclo[3.2.1]octanes

Russian Journal of General Chemistry - The reaction of furfural with secondary amines and isopropyl cyanoacetate gave previously unkown diisopropyl esters of...     

Noncovalent Interactions of π Systems with Sulfur: The Atomic Chameleon of Molecular Recognition

The relative strength of noncovalent interactions between a thioether sulfur atom and various π systems in designed top pan molecular balances was determined by NMR spectroscopy. Compared to its oxygen counterpart, the sulfur atom displays a remarkable ability to interact with almost equal facility over the entire range of π systems studied, with the simple alkene emerging as the most powerful partner. With the exception of the O???heteroarene interaction, all noncovalent interactions of sulfur with π systems are favoured over oxygen.     

A comparative study of the thermodynamic properties at the air–water interface and in the bulk of structurally related phenothiazine drugs aqueous solutions

Surface tension, conductivity, density, and ultrasound velocity measurements have been performed in order to determine in a systematic manner some of the aggregation properties of the phenothiazine drugs promazine and triflupromazine hydrochlorides. Both drugs are structurally related, differing in an extra CF₃ group in the triflupromazine molecular structure. Surface tension data showed that the presence of an extra CF₃ in the molecular structure of triflupromazine involves a higher hydrophobicity of this drug and a restriction in the number of conformations molecules can adopt due to the presence of this bulkier atomic group. This involves a larger surface area in order to accommodate triflupromazine molecules at the interface. From conductivity measurements at different temperatures, the thermodynamic quantities of the micellization process of these drugs indicate that the aggregation is a spontaneous process, mainly enthalpic, where the London-dispersion forces play an active role. Using density and ultrasound velocity measurements, apparent molar volume and adiabatic compressibility of aqueous solutions of the amphiphilic cationic drugs have been determined. Positive deviations from the Debye–Hückel limiting law of the apparent molar volume were obtained from both drugs over the whole temperature range, which provides evidence of possible pre-association at concentrations below the critical concentration. Apparent molar adiabatic compressibility of the aggregates formed by these drugs was typical of those corresponding for an aggregate formed by a stacking process.     

Synthesis of bicyclo[2.2.2]octane-2,3,5,6,7,8 hexols (Bishomoinositols) as glycosidase inhibitors

For the construction of the bicyclo[2.2.2]octane skeleton, 2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole was reacted with vinylene carbonate to give two isomeric cycloadditon products having the bicyclo[2.2.2]octane skeleton. Hydrolysis of the ketal ring and the opening of the carbonate functionality, followed by hydroxylation of the remaining double bond resulted in the formation of a symmetrical hexol. Epoxidation of the double bond in the cycloaddition products and the subsequent ring-opening reactions produce two additional hexol derivatives. One of the synthesized molecules exhibited enzyme-specific inhibition against alpha-glycosidase.