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241.
Rodrigues e Silva AA da Silva Góes AJ de Lima WT de Souza Maia MB 《Chemical & pharmaceutical bulletin》2003,51(12):1351-1355
The search for new anti-inflammatory drugs has been constant in several research centers. The use of the Bioisostery concept allows the elaboration of new bioactive compounds with different properties through the introduction of substitute groups in one or more positions of a main molecule with known biological activity. Preliminary works accomplished at our laboratory with 2,4-thiazolidinedione isosters demonstrated inhibitory activity on edema formation for N-tryptophyl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2,4-thiazolidinedione (GS28) and N-tryptophyl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene) rhodanine (GS26). We verified the antiedematogenic and ulcerogenic activity of these two compounds in Wistar rats. The carrageenan induced paw edema suffered significant (p<0.05) inhibition (28.36% on average) for GS28 (100 mg/kg; v.o.) during the entire time of the experiment. GS26 (50 and 100 mg/kg; v.o.) significantly inhibited (p<0.05) the paw edema dextran induced (22.1 and 27.8%, for the respective doses) after 180 min. The compounds GS26 and GS28 did not show ulcerogenic activity on gastric mucous. The results suggest antiedematogenic action for both compounds without the appearance of gastric lesions. 相似文献
242.
243.
Stephen D. Pastor R. K. Rodebaugh Paul A. Odorisio Benoit Pugin Grety Rihs Antonio Togni 《Helvetica chimica acta》1991,74(6):1175-1193
The original suggestion that a through-space mechanism was operative in the seven-bond J(P, P) coupling constant of 30.3 Hz observed for 3.3′-bis(1,1-dimethylethyl)-2,2′-[3,3′,5,5′-tetrakis(1,1-dimethylethyl)-1,1′-biphenyl-2,2′-diyl]bis(oxy)}bis[1,3,2-oxazaphospholidine] ( 1a )) was investigated. In the solid-state CP-MAS 31PNMR spectrum of 1a , two nonequivalent P -atoms were observed; sufficient resolution could not be obtained to determine whether P, P coupling was present. The preparation and spectral data of the N-methyl analogue 1b and of the acyclic N-isopropyl analogue 6 (Scheme 1) provided evidence that a) the essentially exclusive formation (R*, R*,S*)- 1a in the reaction of the disodium biphenyldiolate 3a with the phosphorochloridite 4a is the result of significant differences in the free energy of activation (ΔG*) for the formation of the various diastereoisomers due to the steric congestion within the molecule and that b) the magnitude of the observed P,P coupling is dependent upon the degree of conformational freedom within the molecule. In the 31P-NMR spectrum of the P-sulfide 7 , which was prepared by the reaction of la with sulfur, 2s resonances were observed that strongly suggested that the lone electrons pair on P are involved in the mechanism for the transmission of coupling data. The (4S,5R) -12 and (4R, 5S) -12 of la were prepared in a three-step reaction sequence starting from the corresponding enantiomerically pure norephredine 8 (Scheme 2). Both (4S, 5R)- and (4R, 5S) -12 were obtained as a diastereoisomer mixture that differ by the configuration of the axis of chirality, i.e., (R*R*,R*)- and (R*,S*,R*) -12 were obtained. The major diastereoisomer was obtained upon recrystallization, and the atropisomers were observed to equilibrate in solution by monitoring the H? C(5) resonance in the 1H-NMR with time (ΔG° = 0.4 kcal/mol; Fig. 2). The process observed corresponds to the restricted rotation about the central single bond of the biphenyl system. The isolation of an atropisomer with only a single ortho substituent on each aryl ring is quite rare. In the 13C-NMR spectrum of both (R*,R*,R*)- and (R*,S*,R*) -12 , C(5) is two-bond-coupled to the oxazaphospholidine P-atom (2J(C(5),P((2)) = 8.5 Hz) that is further virtually coupled to the P-atom of the other oxazaphospholidine ring (7J(P(2),P(2′)) = 30 Hz; 9J(C(5),P(2′)) = 0 Hz; δ(P(2)) = δ(P(2′)) = 136 ppm. In the 31P-NMR spectrum of (R*,R*,S*) -12 , which was prepared from the racemic chloridite (mixture of three diastereoisomers was obtained), a 7J(P(2),P(2′) of 36 Hz was observed. These observations provide strong evidence that seven-bond P,P coupling occurs in all three diastereoisomers of 12 . The observed P,P coupling is both independent of the configuration of the chiral axis and the configuration of the asymmetric P-centers. This independence of P,P coupling upon the configuration on P implies also the independence of the observed coupling upon the orientation of the lone-pair of electrons on P provided that the conformations of the diastereoisomers are similar in solution. The X-ray crystal structure of the complex formed from 1a and dichloro(cycloocta-1,5-diene)platinum(II) was obtained and the solid-state structure discussed. The major diastereoisomer of (4S,5R) -12 was used as a chiral ligand in asymmetric hydrosilylation and hydrogenation reactions (Scheme 3). 相似文献
244.
Antonio Fernández-Ramos Benjamin A. Ellingson Rubén Meana-Pañeda Jorge M. C. Marques Donald G. Truhlar 《Theoretical chemistry accounts》2007,118(4):813-826
This article shows how to evaluate rotational symmetry numbers for different molecular configurations and how to apply them
to transition state theory. In general, the symmetry number is given by the ratio of the reactant and transition state rotational
symmetry numbers. However, special care is advised in the evaluation of symmetry numbers in the following situations: (i)
if the reaction is symmetric, (ii) if reactants and/or transition states are chiral, (iii) if the reaction has multiple conformers
for reactants and/or transition states and, (iv) if there is an internal rotation of part of the molecular system. All these
four situations are treated systematically and analyzed in detail in the present article. We also include a large number of
examples to clarify some complicated situations, and in the last section we discuss an example involving an achiral diasteroisomer. 相似文献
245.
Complete 1H and 13C NMR assignments of aurasperone A and fonsecinone A, two bis-naphthopyrones produced by Aspergillus aculeatus 总被引:1,自引:0,他引:1
Campos FR Barison A Daolio C Ferreira AG Rodrigues-Fo E 《Magnetic resonance in chemistry : MRC》2005,43(11):962-965
Complete assignments of 1H and 13C NMR chemical shifts of the polyketides aurasperone A and fonsecinone A were made by means of nuclear Overhauser enhancement and heteronuclear NMR correlation experiments. These compounds were isolated for the first time from Aspergillus aculeatus, an endophytic fungus obtained from leaves of Melia azedarach(Meliaceae). 相似文献
246.
Belpassi L Tarantelli F Sgamellotti A Quiney HM 《The Journal of chemical physics》2005,122(18):184109
An implementation of the generalized gradient approximation within the four-component formulation of relativistic density-functional theory using G-spinor basis sets is presented. This approach is based on the direct evaluation of the relativistic density and its gradient from the G-spinor amplitudes and gradients without explicit reference to the total density matrix. This proves to be a particularly efficient scheme, with an intrinsic computational cost that scales linearly with the number of G-spinor basis functions. In order to validate this new implementation, incorporated in the parallel version of the program BERTHA, a detailed study of the diatomic system CsAu is also reported. The spectroscopic constants D(e),r(e),omega(e), and x(e)omega(e) and the dipole moment mu have been calculated and compared with the best available theoretical and experimental data. The sensitivity of our results to the details of the numerical schemes used to evaluate the matrix elements is analyzed in detail. Also presented is a comparative study of molecular properties in the alkali auride series which have been obtained using several standard non-relativistic density functionals. 相似文献
247.
Tatjana Topalovic Vincent A. Nierstrasz Lorenzo Bautista Dragan Jocic Antonio Navarro Marijn M. C. G. Warmoeskerken 《Cellulose (London, England)》2007,14(4):385-400
Hydrogen peroxide can be catalyzed to bleach cotton fibers at temperatures as low as 30°C by incorporating dinuclear tri-μ-oxo
bridged manganese(IV) complex of the ligand 1,4,7-trimethyl-1,4,7-triazacyclononane (MnTACN) as the catalyst in the bleaching
solution. The catalytic system was found to be more selective under the conditions applied than the non-catalytic H2O2 system, showing better bleaching performance while causing slightly lower decrease in degree of polymerization (DP) of cellulose.
In order to gain fundamental knowledge of the bleach effect on cotton fibers and cellulose as its main component, especially
after catalytic bleaching, X-ray Photoelectron Spectroscopy (XPS) was used to study surface chemical effects. The Washburn
method was applied to investigate wetting properties, and liquid porosity was used to obtain pore volume distribution (PVD)
plots. Parallel analyzes performed on model cotton fabric, i.e. “clean” cotton fabric stained with morin - a pigment regularly
found in native cotton fiber, helped to differentiate between pigment oxidation and other bleaching effects produced on the
(regular) industrially scoured cotton fabric. Bleaching was not limited to the chemical action but also affected cotton fiber
capillary parameters most likely due to the removal of non-cellulosic materials as well as chain-shortened cellulose. 相似文献
248.
Prisco Prete Antonino Fiorentino Luigi Rizzo Antonio Proto Raffaele Cucciniello 《Current Opinion in Green and Sustainable Chemistry》2021
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249.
Puertas AM Fernández-Barbero A Javier de Las Nieves F Rull LF 《Langmuir : the ACS journal of surfaces and colloids》2004,20(22):9861-9867
The structure of colloidal clusters formed by long-range attractive interactions under diluted conditions is studied by means of Monte Carlo simulations. For a not-too-long attraction range, clusters show self-similar internal structure with lower density than that typical for diffusive aggregation. For long-range interactions, low kappa, nonfractal clusters are formed (dense at short scales but open at long ones). The dependence on the volume fraction shows that more-compact clusters are grown the higher the colloidal density for diffusive aggregation and attraction-driven aggregation in the fractal regime. The whole trend is explained in terms of the interpenetration among aggregates. In attraction-driven aggregations, the interpenetration of clusters competes with aggregation in the tips of the clusters, causing low-density clusters. 相似文献
250.
Soft PVC is employed for the manufacturing of a wide range of products with different properties and a relatively low cost. The utilization of soft PVC is restricted by the poor thermal, chemical and mechanical resistance properties. Also, plasticizer migration can modify the properties or can make useless the materials for some applications because of toxicity or a general loss of properties. PVC crosslinking is the most effective way to improve mechanical and transport properties of rigid or flexible PVC at high temperatures, but at the same time the thermal stability of PVC may be significantly reduced. In this work, the crosslinking reaction of plasticized poly(vinyl chloride) (PVC) through difunctional amines was studied. The mechanisms involved in the crosslinking reaction were explained by Fourier transform infrared (FTIR) analysis. The thermal activated crosslinking reaction was studied by cone and plate rheometry, analyzing the evolution of viscoelastic properties of the suspension as a function of time and temperature. The effect of the addition of crosslinking agents on the thermal stability of the polymer was studied by thermogravimetric analysis (TGA), which revealed that crosslinking reactions promote thermal degradation phenomena in the polymer matrix. This is attributed to the formation of HCl and other species promoting polymer degradation during crosslinking, thus leading to higher weight loss during thermal treatment with respect to unmodified PVC plastisols. This was also confirmed by an evident yellowing after crosslinking, especially at higher temperatures. 相似文献