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91.
Antonia Neels Helen Stoeckli-Evans Burhkard Costisella Harald Jancke Kenneth D. Knudsen Philip Pattison 《Helvetica chimica acta》1999,82(1):35-43
The structure of [(dimethylamino)methylene]bis[phosphonic acid] dihydrate (C3H11NO6P2⋅2 H2O; 1 ) was solved ab initio from synchrotron powder X-ray diffraction data. The structure determination was based on direct methods combined with difference Fourier techniques, and the refinement was carried out using the Rietveld method. Using this high-quality diffraction pattern, it was possible to index a second phase which corresponds to the structure of the known [(dimethylamino)methylene]bis[phosphonic acid] monohydrate ( 2 ). [(Dimethylamino)methylene]bis[phosphonic acid] dihydrate ( 1 ) is monoclinic, space group P21/c, Z=4, with a=10.6644(1), b=9.1599(1), c=10.5213(1) Å, and β=98.353(1)°. The structure analysis indicates two non-equivalent P-atoms in the molecule of 1 which are also observed in the corresponding monohydrate 2 and unhydrated form 3 . All three compounds exhibit extended H-bonding networks which result in remarkably different 31P-NMR spectra. The [(dimethylamino)methylene]bis[phosphonic acids] 1 – 3 crystallize in the betaine-type structure which, therefore, contains two nonequivalent P-atoms. The −P(=O)(OH)2 and −P(=O)(OH)O− groups of 1 – 3 are involved in a number of strong H-bonds which can be characterized by the different 31P-NMR chemical shifts of the two P-atoms of 1 – 3 . 相似文献
92.
Antonia Di Mola Francesco Ferdinando Summa Patrizia Oliva Francesco Lelj Stefano Remiddi Ludovica Silvani Antonio Massa 《Molecules (Basel, Switzerland)》2021,26(23)
The properties of mixtures of two polysaccharides, arabinogalactan (AG) and hyaluronic acid (HA), were investigated in solution by the measurement of diffusion coefficients D of water protons by DOSY (Diffusion Ordered SpectroscopY), by the determination of viscosity and by the investigation of the affinity of a small molecule molecular probe versus AG/HA mixtures in the presence of bovine submaxillary mucin (BSM) by 1HNMR spectroscopy. Enhanced mucoadhesive properties, decreased mobility of water and decreased viscosity were observed at the increase of AG/HA ratio and of total concentration of AG. This unusual combination of properties can lead to more effective and long-lasting hydration of certain tissues (inflamed skin, dry eye corneal surface, etc.) and can be useful in the preparation of new formulations of cosmetics and of drug release systems, with the advantage of reducing the viscosity of the solutions. 相似文献
93.
A series of bimetallic N-heterocyclic carbene (NHC) ruthenium(II) complexes were synthesized, which comprise two [RuCl(2)(cymene)(NHC)] units that are interlinked via the NHC nitrogens by alkyl chains of different length. Electrochemical characterization revealed two mutually dependent oxidation processes for the complex with a methylene linker, indicating moderate intramolecular electronic coupling of the two metal centers (class II system). The degree of coupling decreases rapidly upon increasing the number of CH(2) units in the linker and provides essentially decoupled class I species when propylene or butylene linkers are used. Electrochemical analyses combined with structural investigations suggest a through-bond electronic coupling. Replacement of the alkyl linker with a p-phenylene group afforded cyclometalated complexes, which were considerably less stable. The electronic coupling in the methylene-linked complex and the relatively robust NHC-ruthenium bond may provide access to species that are switchable on the molecular scale. 相似文献
94.
Antonia Sacchi Paolo De Caprariis Luciano Mayol Giovanni De Martino 《Journal of heterocyclic chemistry》1995,32(3):1067-1069
4-Hydroxy-3-phenylprolines were synthesized via 1-acetyl-2,2-diethoxycarbonyl-2,3-dihydro-3-phenyl-1H-pyrrole. Reversed phase hplc resulted in the isolation of the products which were characterized by 1H and 13C nmr spectroscopy. 相似文献
95.
Depalo N Mallardi A Comparelli R Striccoli M Agostiano A Curri ML 《Journal of colloid and interface science》2008,325(2):558-566
Organic capped luminescent CdSe@ZnS nanocrystals (NCs) have been incorporated in block copolymer micelles, formed by polyethylene glycol modified phospholipids (PEG lipids). The obtained water soluble NC including PEG lipid micelles have been conjugated with bovine serum albumine (BSA). The entire process has been investigated by using optical, structural and electrophoretic complementary techniques. Such an integrated approach has allowed to elucidate critical issues, such as the time and temperature effects on the phase behavior of the PEG lipid/NC aggregate structures, the emitting properties of the NCs before and after micelle formation and bio-conjugation and the effect of conjugation on the biological moiety. The overall results provide relevant insight on the fabrication of the bio-conjugates, on their stability and on preparative procedure reproducibility, in view of the use of the resulting protein decorated NCs as multifunctional hybrid building blocks for the fabrication of a variety of supramolecular assemblies to exploit in biological sensing and diagnostic applications. 相似文献
96.
Dr. Hamed Shaykhalishahi Dr. Aziz Gauhar Michael M. Wördehoff Dr. Clara S. R. Grüning Antonia N. Klein Dr. Oliver Bannach Dr. Matthias Stoldt Prof. Dr. Dieter Willbold Prof. Dr. Torleif Härd Dr. Wolfgang Hoyer 《Angewandte Chemie (International ed. in English)》2015,54(30):8837-8840
Conversion of the intrinsically disordered protein α‐synuclein (α‐syn) into amyloid aggregates is a key process in Parkinson’s disease. The sequence region 35–59 contains β‐strand segments β1 and β2 of α‐syn amyloid fibril models and most disease‐related mutations. β1 and β2 frequently engage in transient interactions in monomeric α‐syn. The consequences of β1–β2 contacts are evaluated by disulfide engineering, biophysical techniques, and cell viability assays. The double‐cysteine mutant α‐synCC, with a disulfide linking β1 and β2, is aggregation‐incompetent and inhibits aggregation and toxicity of wild‐type α‐syn. We show that α‐syn delays the aggregation of amyloid‐β peptide and islet amyloid polypeptide involved in Alzheimer’s disease and type 2 diabetes, an effect enhanced in the α‐synCC mutant. Tertiary interactions in the β1–β2 region of α‐syn interfere with the nucleation of amyloid formation, suggesting promotion of such interactions as a potential therapeutic approach. 相似文献
97.
Boskovic C Sieber A Chaboussant G Güdel HU Ensling J Wernsdorfer W Neels A Labat G Stoeckli-Evans H Janssen S 《Inorganic chemistry》2004,43(16):5053-5068
Nine members of a new family of polynuclear ferric complexes have been synthesized and characterized. The reaction of Fe(O(2)CMe)(2) with polydentate Schiff base proligands (H(2)L) derived from salicylidene-2-ethanolamine, followed in some cases by reaction with carboxylic acids, has afforded new complexes of general formulas [Fe(2)(pic)(2)(L)(2)] (where pic(-) is the anion of 2-picolinic acid), [Fe(3)(O(2)CMe)(3)(L)(3)], [Fe(4)(OR)(2)(O(2)CMe)(2)(L)(4)], and [Fe(5)O(OH)(O(2)CR)(4)(L)(4)]. The tri-, tetra-, and pentanuclear complexes all possess unusual structures and novel core topologies. M?ssbauer spectroscopy confirms the presence of high-spin ferric centers in the tri- and pentanuclear complexes. Variable-temperature magnetic measurements suggest spin ground states of S = 0, 1/2, 0, and 5/2 for the bi-, tri-, tetra-, and pentanuclear complexes, respectively. Fits of the magnetic susceptibility data have provided the magnitude of the exclusively antiferromagnetic exchange interactions. In addition, an easy-axis-type magnetic anisotropy has been observed for the pentanuclear complexes, with D values of approximately -0.4 cm(-)(1) determined from modeling the low-temperature magnetization data. A low-temperature micro-SQUID study of one of the pentanuclear complexes reveals magnetization hysteresis at nonzero field. This is attributed to an anisotropy-induced energy barrier to magnetization reversal that is of molecular origin. Finally, an inelastic neutron scattering study of one of the trinuclear complexes has revealed that the magnetic behavior arises from two distinct species. 相似文献
98.
Antonia Wachter-Zeh Alexander Zeh Martin Bossert 《Designs, Codes and Cryptography》2014,71(2):261-281
A new probabilistic decoding algorithm for low-rate interleaved Reed–Solomon (IRS) codes is presented. This approach increases the error correcting capability of IRS codes compared to other known approaches (e.g. joint decoding) with high probability. It is a generalization of well-known decoding approaches and its complexity is quadratic with the length of the code. Asymptotic parameters of the new approach are calculated and simulation results are shown to illustrate its performance. Moreover, an upper bound on the failure probability is derived. 相似文献
99.
100.
Martin Linden Silja Hofmann Antonia Herman Nicole Ehler Robin M. Bär Siegfried R. Waldvogel 《Angewandte Chemie (International ed. in English)》2023,62(9):e202214820
Pyrazolines and pyrazoles are common and important motifs of pharmaceutical agents and agrochemicals. Herein, the first electrochemical approach for their direct synthesis from easily accessible hydrazones and dipolarophiles up to decagram scale is presented. The application of a biphasic system (aqueous/organic) even allows for the conversion of highly sensitive alkenes, wherein inexpensive sodium iodide is employed in a dual role as supporting electrolyte and mediator. In addition, mechanistic insight into the reaction is given by the isolation of key step intermediates. The relevance of the presented reaction is underlined by the synthesis of commercial herbicide safener mefenpyr-diethyl in good yields. 相似文献