A Comprehensive Investigation of Interactions between Antipsychotic Drug Quetiapine and Human Serum Albumin Using Multi-Spectroscopic,Biochemical, and Molecular Modeling Approaches

Quetiapine (QTP) is a short-acting atypical antipsychotic drug that treats schizophrenia or manic episodes of bipolar disorder. Human serum albumin (HSA) is an essential transport protein that transports hormones and various other ligands to their intended site of action. The interactions of QTP with HSA and their binding mechanism in the HSA-QTP system was studied using spectroscopic and molecular docking techniques. The UV-Vis absorption study shows hyperchromicity in the spectra of HSA on the addition of QTP, suggesting the complex formation and interactions between QTP and HSA. The results of intrinsic fluorescence indicate that QTP quenched the fluorescence of HSA and confirmed the complex formation between HSA and QTP, and this quenching mechanism was a static one. Thermodynamic analysis of the HSA-QTP system confirms the involvement of hydrophobic forces, and this complex formation is spontaneous. The competitive displacement and molecular docking experiments demonstrated that QTP is preferentially bound to HSA subdomain IB. Furthermore, the CD experiment results showed conformational changes in the HSA-QTP system. Besides this, the addition of QTP does not affect the esterase-like activity of HSA. This study will help further understand the credible mechanism of transport and delivery of QTP via HSA and design new QTP-based derivatives with greater efficacy.     

On self-reciprocal polynomials

In this paper we establish a sharp result concerning integral mean estimates for self-reciprocal polynomials.     

Investigation the effect of lattice angle on the band gap width in 3D phononic crystals with rhombohedral(I) lattice

In this paper, the propagation of acoustic waves in the phononic crystal of 3D with rhombohedral(I) lattice is studied theoretically. The crystal composite constituted of nickel spheres embedded in epoxy. The calculations of the band structure and density of states are performed with the plane wave expansion method in the irreducible part of Brillouin zone. In the present work, we have investigated the effect of lattice angle on the band structure and width of the band gap rhombohedral(I) lattice in the irreducible part of the first Brillouin zone and its planes separately. The results show that more than one complete band gape are formed in the four planes of the irreducible part. The most complete band gaps are formed in the (111) plane and the widest complete band gap in (443) with an angle greater than 80 \(^{\circ }\) . So, if the sound passes through the (111) and (443) planes for the lattice angle close to 90 \(^{\circ }\) , the crystal phononic displays the excellent insulation behavior. Moreover, in the other planes, the lattice angle does not affect on the width and the number of band gaps. Also, for the filling fraction 5 %, the widest complete band gap is formed. These results are consistent with the effect of symmetry on the band gap width, because the (111) plane has the most symmetry.     

On the zeros of polynomials

In this paper we extend a classical result due to Cauchy and its improvement due to Datt and Govil to a class of lacunary type polynomials.     

Inequalities for the Polar Derivatives of a Polynomial

Let P(z) be a polynomial of degree n, having all its zeros in|z| ≤1In this paper, we estimate kth polar derivative of P(z) on|z|= 1 and thereby obtain compact generalizations of some known results which among other things yields a refinement of a result due to Paul Tura'n.     

A Novel Synthetic Method and Potential Application of a Sulfanilic Acid-Based Surfactant

A novel synthetic method was developed to prepare a difunctional surfactant using sulfanilic acid and dodecyl bromide. In the first step, sulfanilic acid was protected by acetic anhydride. Then, Friedel–Crafts alkylation of the synthesized acetanilide with dodecyl bromide was performed in the presence of aluminum chloride. The protecting group (amide) was removed easily by acid hydrolysis. The formation of surfactant was confirmed with Fourier transform infrared and proton nuclear magnetic resonance spectroscopy. The demulsification property of this surfactant was studied using brine-fuel oil emulsion, and its result was compared with a commercially available demulsifier. The results showed that 52% of water was separated from emulsion at room temperature, but at elevated temperature 98% of water was separated from brine-fuel oil emulsion.     

Partially resorbable composite bone plate with controlled degradation rate, desired mechanical properties and bioactivity

Rate of polymer degradation is very important for implantable biomaterials since controlling the degradation rate may complement the biological response and affected mechanical property requirements. In spite of numerous publications on the potential use of combinations of poly lactic acid/bioactive glass fillers for degradable bone plate, little information exists on the controlling degradation rate and its effects on the other aspects such as biomechanical compatibility, bioactivity, etc. Our previous study revealed that a composite bone plate consist of poly l-lactic acid/braided bioactive glass fibers has the initial mechanical properties near to cortical bone. In this study, degradation rate and mechanical behavior of the composite bone plate were assessed, and also degradation rate was controlled by using proper manufacturing process and improving bonding between matrix and reinforcement. Moreover, bioactivity of the composite was considered before and after controlling degradation rate, because of the important role of bioactivity and ion release in healing acceleration. Results showed that degradation process of the composite could be controlled properly. Strength of the treated composite decreased only about 5% through 2 weeks and about 35% after 8 weeks while, the strength loss for the untreated composites was about 50 and 70 percent after 2 weeks and 8 weeks of degradation respectively. Although calcium-phosphate formation on the surface of the composite was postponed in the treated samples, the bioactivity of the composite remained unchanged and bone-like apatite was formed on the composite surface which is important for the application of the composite in bone tissue environment.     

Synthesis of an ion-imprinted sorbent by surface imprinting of magnetized carbon nanotubes for determination of trace amounts of cadmium ions

Microchimica Acta - The authors report on the preparation of sol-gel coated magnetized carbon nanotubes whose surface were imprinted with Cd2+ ions and the application of these materials on...     

Population Structure Analysis and Selection of Core Set among Common Bean Genotypes from Jammu and Kashmir,India

Understanding the genetic diversity of a crop is useful for its effective utilization in breeding programmes. For better understanding of the genetic variability in common bean, the first and foremost step is to study its genetic diversity. In the present investigation, 138 genotypes of common bean collected from various regions of Jammu and Kashmir, India, representing major common bean growing areas of this region, were evaluated using 23 SSRs. These SSRs were found highly polymorphic and possess high values for various parameters indicating their high discriminatory power. The average PIC value observed was 0.692, with 0.730 as average gene diversity value, and 0.267 as heterozygosity. Twenty-three SSRs produced a total of 251 alleles. The dendrogram generated with un-weighted neighbour joining cluster analysis grouped genotypes into three main clusters with various degrees of sub-clustering within the clusters. The model-based STRUCTURE analysis using 23 SSR markers identified a population with 3 sub-populations which corresponds to distance-based groupings with average F _ST value and expected heterozygosity of 0.1497 and 0.6696, respectively, within the sub-population, as such high level of genetic diversity was observed within the population. Further, Core Hunter II was used to identify a core set of 96 diverse genotypes. This core set of diverse 96 genotypes is a potential resource for association mapping studies and can be used by breeders as a material to make desirable genetic crosses to generate elite varieties for the fulfilling global market needs. These findings have further implications in common bean breeding as well as conservation programs.