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11.
Maria De Fenza Anna Esposito Daniele DAlonzo Annalisa Guaragna 《Molecules (Basel, Switzerland)》2021,26(6)
The de novo synthesis of piperidine nucleosides from our homologating agent 5,6-dihydro-1,4-dithiin is herein reported. The structure and conformation of nucleosides were conceived to faithfully resemble the well-known nucleoside drugs Immucillins H and A in their bioactive conformation. NMR analysis of the synthesized compounds confirmed that they adopt an iminosugar conformation bearing the nucleobases and the hydroxyl groups in the appropriate orientation. 相似文献
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Dr. Annalisa Mancini Dr. M. Carla Aragoni Dr. Neil Bricklebank Dr. Carlo Castellano Prof. Francesco Demartin Prof. Francesco Isaia Prof. Vito Lippolis Dr. Anna Pintus Dr. Massimiliano Arca 《化学:亚洲杂志》2013,8(3):639-647
The reactions of 4,5,6,7‐tetrathiocino‐[1,2‐b:3,4‐b′]‐1,3,8,10‐tetrasubstituted‐diimidazolyl‐2,9‐dithiones (R2,R′2‐todit; 1 : R=R′=Et; 2 : R=R′=Ph; 3 : R=Et, R′=Ph) with Br2 exclusively afforded 1:1 and 1:2 “T‐shaped” adducts, as established by FT‐Raman spectroscopy and single‐crystal X‐ray diffraction in the case of complex 1? 2 Br2. On the other hand, the reactions of compounds 1 – 3 with molecular I2 provided charge‐transfer (CT) “spoke” adducts, among which the solvated species 3? 2 I2 ? (1?x)I2 ? x CH2Cl2 (x=0.94) and ( 3 )2 ? 7 I2 ? x CH2Cl2, (x=0.66) were structurally characterized. The nature of all of the reaction products was elucidated based on elemental analysis and FT‐Raman spectroscopy and supported by theoretical calculations at the DFT level. 相似文献
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Martina Mazzoni Lorenzo Franco Alberta Ferrarini Carlo Corvaja Giovanni Zordan Gianfranco Scorrano 《Liquid crystals》2013,40(2):203-208
A nitroxide [60]fullerene adduct containing a pyrrolidine-1-oxyl group has been synthesized. Its orientational order in the nematic phase of the liquid crystal solvent 4,4′-azoxyanisole (PAA) has been measured from the variation of the EPR spectral parameters on passing from the isotropic to the nematic phase. Highly resolved EPR lines allow for precise evaluation of the shifts of the g, a N and a H values. Since the g and the hyperfine tensors are known, the order matrix could be obtained. This is compared with the one calculated with a theoretical model based on short range solute-solvent interactions, which predicts a considerable degree of orientation of the molecular axes, despite the almost spherical shape of the molecule. The agreement with experimental findings is quite good and it is further improved if a bent structure of the pyrrolidine ring is taken into account. 相似文献
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Annalisa Maruca Roberta Rocca Raffaella Catalano Francesco Mesiti Giosu Costa Delia Lanzillotta Alessandro Salatino Francesco Ortuso Francesco Trapasso Stefano Alcaro Anna Artese 《Molecules (Basel, Switzerland)》2020,25(23)
Mushrooms can be considered a valuable source of natural bioactive compounds with potential polypharmacological effects due to their proven antimicrobial, antiviral, antitumor, and antioxidant activities. In order to identify new potential anticancer compounds, an in-house chemical database of molecules extracted from both edible and non-edible fungal species was employed in a virtual screening against the isoform 7 of the Histone deacetylase (HDAC). This target is known to be implicated in different cancer processes, and in particular in both breast and ovarian tumors. In this work, we proposed the ibotenic acid as lead compound for the development of novel HDAC7 inhibitors, due to its antiproliferative activity in human breast cancer cells (MCF-7). These promising results represent the starting point for the discovery and the optimization of new HDAC7 inhibitors and highlight the interesting opportunity to apply the “drug repositioning” paradigm also to natural compounds deriving from mushrooms. 相似文献
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Kathryn A. Dooley Annalisa Chieli Aldo Romani Stijn Legrand Costanza Miliani Koen Janssens John K. Delaney 《Angewandte Chemie (International ed. in English)》2020,59(15):6046-6053
Vincent van Gogh used fugitive red lake pigments that have faded in some paintings. Mapping their distribution is key to understanding how his paintings have changed with time. While red lake pigments can be identified from microsamples, in situ identification and mapping remain challenging. This paper explores the ability of molecular fluorescence imaging spectroscopy to identify and, more importantly, map residual non‐degraded red lakes. The high sensitivity of this method enabled identification of the emission spectra of eosin (tetrabromine fluorescein) lake mixed with lead or zinc white at lower concentrations than elemental X‐ray fluorescence (XRF) spectroscopy used on account of bromine. The molecular fluorescence mapping of residual eosin and two carmine red lakes in van Gogh's The Olive Orchard is demonstrated and compared with XRF imaging spectroscopy. The red lakes are consistent with the composition of paint tubes known to have been used by van Gogh. 相似文献
18.
Eric Mayer-Santos Tatjana Maravic Allegra Comba Patricia Moreira Freitas Giovanna Bueno Marinho Claudia Mazzitelli Edoardo Mancuso Nicola Scotti Federica Florenzano Lorenzo Breschi Annalisa Mazzoni 《Molecules (Basel, Switzerland)》2022,27(5)
This study aimed to investigate matrix metalloproteinase (MMP) activity in human dentin using in-situ and gelatin zymography, after at-home and in-office bleaching, related to their clinical exposure times. Dentin specimens (n = 5) were treated with 35% hydrogen peroxide (50 min per session/4 sessions), 10% carbamide peroxide (180 min/21 sessions), or no treatment. All were subjected to in-situ zymography. Dentin slices were, subsequently, obtained, covered with fluorescein-conjugated gelatin, and examined with confocal laser-scanning microscopy. The fluorescence intensity was quantified and statistically analyzed using one-way ANOVA and Bonferroni tests (α = 0.05). Furthermore, gelatin zymography was performed on protein extracts obtained from dentin powder (N = 8 teeth), treated with hydrogen peroxide or carbamide peroxide, with different exposure times (10/50 min for hydrogen peroxide; 252/1260 min for carbamide peroxide). The results of the in-situ zymography showed no statistical differences between the bleached specimens and the control group, with a medium level of gelatinolytic activity expressed in the dentin tubules. The results of gelatin zymography showed an increased expression of pro-MMP-9 in carbamide peroxide groups. The expression of pro-MMP-2 decreased in all the experimental groups. The bleaching treatments performed on the enamel of sound teeth do not influence dentinal enzymatic activity. However, when unprotected dentin tissue is bleached, matrix metalloproteinases are more expressed, particularly when carbamide peroxide is used, proportional to the exposure time. 相似文献
19.
Giulia Vallarino Annalisa Salis Elena Lucarini Federica Turrini Guendalina Olivero Alessandra Roggeri Gianluca Damonte Raffaella Boggia Lorenzo Di Cesare Mannelli Carla Ghelardini Anna Pittaluga 《Molecules (Basel, Switzerland)》2022,27(3)
A new formulation of a pomegranate-peel extract (PEm) obtained by PUAE (Pulsed Ultrasound-Assisted Extraction) and titrated in both ellagic acid (EA) and punicalagin is proposed, characterized and then analyzed for potential health properties in mice suffering from the experimental autoimmune encephalomyelitis (EAE). PEm effects were compared to those elicited by a formulation containing EA (EAm). Control and EAE mice were chronically administered EAm and Pem dissolved in the drinking water, starting from the day 10 post-immunization (d.p.i.), with a “therapeutic” protocol to deliver daily 50 mg/kg of EA. Treated EAE mice did not limit their daily access to the beverage, nor did they show changes in body weight, but they displayed a significant amelioration of “in vivo” clinical symptoms. “Ex vivo” histochemical analysis showed that spinal-cord demyelination and inflammation in PEm and EAm-treated EAE mice at 23 ± 1 d.p.i. were comparable to those in the untreated EAE animals, while microglia activation (measured as Ionized Calcium Binding Adaptor 1, Iba1 staining) and astrocytosis (quantified as glial fibrillar acid protein, GFAP immunopositivity) significantly recovered, particularly in the gray matter. EAm and PEm displayed comparable efficiencies in controlling the spinal pathological cellular hallmarks in EAE mice, and this would support their delivery as dietary supplementation in patients suffering from multiple sclerosis (MS). 相似文献
20.
Ercole Gattiglia Antonio Turturro Davide Ricci Annalisa Bonfiglio 《Macromolecular rapid communications》1995,16(12):919-925
The orientation of the microdomains at the free surface of solvent-cast films of a polystyrene-block-polybutadiene-block-polystyrene triblock copolymer with cyclindrical morphology was studied by coupling transmission electron and scanning force microscopies (SFM-TEM). It was found that the cylinders of polystyrene, which are assembled in grains randomly oriented in the bulk, tend to reorient with the main axis perpendicular to the surface. SFM investigation indicates that the hexagonal symmetry of the cylinders is also maintained at the free surface which is characterized by protrusions and corrugation with size and characteristic distances closely related to the cylindrical morphology visible in the bulk. Good quantitative agreement between TEM and SFM measurements is observed. 相似文献