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91.
92.
Annalisa Zaccaroni Camilla Niccoli Giulia Andreani Dino Scaravelli Maria Carmela Ferrante Antonia Lucisano Gloria Isani 《Central European Journal of Chemistry》2011,9(1):86-93
This study was conducted to determine heavy metals concentrations in tissues of 94 birds belonging to different species from
coastal areas of Naples and Salerno (Southern Italy) in order to provide baseline data concerning trace element levels in
wild birds living in or close to an area characterized by high anthropogenic impact. Additional aim of this study was to verify
if diet influenced metal accumulation, so birds were classified as birds of prey, fish eating birds and insectivorous birds. 相似文献
93.
Christian Gérard Fumio Hiroshima Annalisa Panati Akito Suzuki 《Letters in Mathematical Physics》2012,101(3):305-322
We consider the Nelson model with variable coefficients. Nelson models with variable coefficients arise when one replaces in the usual Nelson model the flat Minkowski metric by a static metric, allowing also the boson mass to depend on position. We study the removal of the ultraviolet cutoff. 相似文献
94.
Candeloro P Tirinato L Malara N Fregola A Casals E Puntes V Perozziello G Gentile F Coluccio ML Das G Liberale C De Angelis F Di Fabrizio E 《The Analyst》2011,136(21):4402-4408
Microinjection techniques and Raman spectroscopy have been combined to provide a new methodology to investigate the cytotoxic effects due to the interaction of nanomaterials with cells. In the present work, this novel technique has been used to investigate the effects of Ag and Fe(3)O(4) nanoparticles on Hela cells. The nanoparticles are microinjected inside the cells and these latter ones are probed by means of Raman spectroscopy after a short incubation time, in order to highlight the first and impulsive mechanisms developed by the cells to counteract the presence of the nanoparticles. The results put in evidence a different behaviour of the cells treated with nanoparticles in comparison with the control cells; these differences are supposed to be generated by an emerging oxidative stress due to the nanoparticles. The achieved results demonstrate the suitability of the proposed method as a new tool for nanotoxicity studies. 相似文献
95.
Andrea Ienco Maria Caporali Ferdinando Costantino Annalisa Guerri Gabriele Manca Simonetta Moneti 《Journal of Coordination Chemistry》2014,67(23-24):3863-3872
Given the ability of forming homomeric amide···amide dimer by iso-nicotinamide (nda), we postulate the existence of a hydrogen bond equivalent of the iso-reticular metal organic nanotubes (MONT) built by using copper, p,p′-diphenylmethylene-diphosphinate (pcp), and bipyridine. We obtained the desired primary arrangement of Cu/pcp/nda consisting of a 1-D chain. Instead of the expected amide/amide dimer, the NH2 groups were engaged in H-bonding networks with the phosphinate ligands in a series of 2-D slabs. The differences and the similarities of the Cu/pcp chains in known MONTs and in the reported structure are also highlighted. 相似文献
96.
Marco Vigliano Annalisa Bianchera Ruggero Bettini Lisa Elviri 《Chromatographia》2013,76(23-24):1761-1766
Two simple and fast C18 and HILIC liquid chromatography–electrospray mass spectrometry methods for the determination of hyaluronic acid (HA) in a mucoadhesive chitosan-based formulation were developed and validated. The performances of both methods were compared in terms of validation parameters and matrix effect. A simple sample preparation method based on sulphuric acid-based degradation was optimized for the detection of HA fragments (i.e. m/z 380 2-mer, m/z 759 4-mer, m/z 1,138 8-mer and m/z 1,518 16-mer). By operating under selected ion-monitoring mode, excellent selectivity towards chitosan fragments was obtained. For validation, good linearity, detection limits (<4 μg mL?1) and precision (RSD % < 16 %) were generally obtained on matrix with both columns. However, HILIC column exhibited improved performances in terms of HA fragment separation and selectivity. By analyzing on the C18 column the chitosan-based formulation and sample extracts from pig mucosa treated with the formulation, matrix effects exhibited a dependence of signal suppression degree (ranging from 37 to 83 %) as a function of the HA fragment dimension. The HILIC column afforded instead a significantly reduced suppression degree (ranging from 1 to 16 %) and a better separation. These findings demonstrated the improved performances of the HILIC column with respect to conventional C18 mechanism for the analysis of HA fragments in complex matrices. 相似文献
97.
Annalisa Chiavaroli Simonetta Cristina Di Simone Alessandra Acquaviva Maria Loreta Libero Claudia Campana Lucia Recinella Sheila Leone Luigi Brunetti Giustino Orlando Nilofar Irene Vitale Stefania Cesa Gokhan Zengin Luigi Menghini Claudio Ferrante 《Molecules (Basel, Switzerland)》2022,27(19)
Pollen extract represents an innovative approach for the management of the clinical symptoms related to prostatitis and pelvic inflammatory disease (PID). In this context, the aims of the present work were to analyze the phenolic composition of a hydroalcoholic extract of PollenAid Plus soft gel capsules, and to evaluate the extract’s cytotoxic effects, in human prostate cancer PC3 cells and human ovary cancer OVCAR-3 cells. Additionally, protective effects were investigated in isolated prostate and ovary specimens exposed to lipopolysaccharide (LPS). The phytochemical investigation identified catechin, chlorogenic acid, gentisic acid, and 3-hydroxytyrosol as the prominent phenolics. The extract did not exert a relevant cytotoxic effect on PC3 and OVCAR-3 cells. However, the extract showed a dose-dependent inhibition of pro-inflammatory IL-6 and TNF-α gene expression in prostate and ovary specimens, and the extract was effective in preventing the LPS-induced upregulation of CAT and SOD gene expression, which are deeply involved in tissue antioxidant defense systems. Finally, a docking approach suggested the capability of catechin and chlorogenic acid to interact with the TRPV1 receptor, playing a master role in prostate inflammation. Overall, the present findings demonstrated anti-inflammatory and antioxidant effects of this formulation; thus, suggesting its capability in the management of the clinical symptoms related to prostatitis and PID. 相似文献
98.
Antonino Lauria Annalisa Guarcello Gaetano Dattolo Anna Maria Almerico 《Tetrahedron letters》2008,49(11):1847-1850
Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a:3′,4′-c]quinoxaline of pharmaceutical interest have been obtained by double site- and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken. 相似文献
99.
Akhil Venugopal Dr. Lorena Ruiz-Perez Dr. K. Swamynathan Dr. Chidambar Kulkarni Dr. Annalisa Calò Dr. Mohit Kumar 《Angewandte Chemie (International ed. in English)》2023,62(8):e202208681
Supramolecular systems chemistry has been an area of active research to develop nanomaterials with life-like functions. Progress in systems chemistry relies on our ability to probe the nanostructure formation in solution. Often visualizing the dynamics of nanostructures which transform over time is a formidable challenge. This necessitates a paradigm shift from dry sample imaging towards solution-based techniques. We review the application of state-of-the-art techniques for real-time, in situ visualization of dynamic self-assembly processes. We present how solution-based techniques namely optical super-resolution microscopy, solution-state atomic force microscopy, liquid-phase transmission electron microscopy, molecular dynamics simulations and other emerging techniques are revolutionizing our understanding of active and adaptive nanomaterials with life-like functions. This Review provides the visualization toolbox and futuristic vision to tap the potential of dynamic nanomaterials. 相似文献
100.