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981.
982.
To overcome the lack of in vivo stability of certain peptides used in cancer treatment and to increase their retention time in the extracellular matrix of the target tissue, the anti-angiogenic WHLPFKC sequence is synthesised at the uppermost branching generation of a poly(ε-lysine) dendron. The root of these dendrons is designed to interact preferentially with macromolecules of the extracellular matrix, whilst the uppermost branching generation of the dendron increased the exposed density of the bioactive peptide. Bioactivity testing of the blockers is performed on HUVECs. The results show that the dendron tethered with VEGF blockers was still able to inhibit proliferation and angiogenesis. Their relatively larger structure did not prevent the interaction with VEGF. 相似文献
983.
Rogge WF Ondov JM Bernardo-Bricker A Sevimoglu O 《Analytical and bioanalytical chemistry》2011,401(10):3069-3082
As part of the Baltimore PM2.5 Supersite study, intensive three-hourly continuous PM2.5 sampling was conducted for nearly
4 weeks in summer of 2002 and as well in winter of 2002/2003. Close to 120 individual organic compounds have been quantified
separately in filter and polyurethane foam (PUF) plug pairs for 17 days for each sampling period. Here, the focus is on (1)
describing briefly the new sampling system, (2) discussing filter/PUF plugs breakthrough experiments for semi-volatile compounds,
(3) providing insight into phase distribution of semi-volatile organic species, and (4) discussing the impact of air pollution
sampling time on human exposure with information on maximum 3- and 24-h averaged ambient concentrations of potentially adverse
health effects causing organic pollutants. The newly developed sampling system consisted of five electronically controlled
parallel sampling channels that are operated in a sequential mode. Semi-volatile breakthrough experiments were conducted in
three separate experiments over 3, 4, and 5 h each using one filter and three PUF plugs. Valuable insight was obtained about
the transfer of semi-volatile organic compounds through the sequence of PUF plugs and a cut-off could be defined for complete
sampling of semi-volatile compounds on only one filter/PUF plug pair, i.e., the setup finally used during the seasonal PM2.5
sampling campaign. Accordingly, n-nonadecane (C19) with a vapor pressure (vp) of 3.25 × 10−4 Torr is collected with > 95% on the filter/PUF pair. Applied to phenanthrene, the most abundant the PAH sampled, phenanthrene
(vp, 6.2 × 10−5 Torr) was collected completely in wintertime and correlates very well with three-hourly PM2.5 ambient concentrations. Valuable
data on the fractional partitioning for semi-volatile organics as a function of season is provided here and can be used to
differentiate the human uptake of an organic pollutant of interest via gas- and particle-phase exposure. Health effects studies
often relay on PM2.5 exposure measurements taken over 24 h or longer. We found that maximum 3-h concentrations are frequently
two to five times higher than that found for maximum 24-h concentrations, an important aspect when considering that short-term
exposure to higher air pollution levels are more likely to overpower defense mechanisms in the human lung with subsequent
adverse effects even at lower pollutant levels. 相似文献
984.
Euterpio MA Cavaliere C Capriotti AL Crescenzi C 《Analytical and bioanalytical chemistry》2011,401(9):2977-2985
Pressurized hot water extraction (PHWE, also known as subcritical water extraction) is commonly considered to be an environmentally
friendly extraction technique that could potentially replace traditional methods that use organic solvents. Unfortunately,
the applicability of this technique is often limited by the very low water solubility of the target compounds, even at high
temperatures. In this paper, the scope for broadening the applicability of PHWE by adjusting the pH of the water used in the
extraction is demonstrated in the extraction of curcumin (which exhibits very limited water solubility) from untreated turmeric
(Curcuma longa L.) rhizomes. Although poor extraction yields were obtained, even at high temperatures when using degassed water or neutral
phosphate buffer as the extraction medium, yields exceeding those obtained by Soxhlet extraction were achieved using highly
acidic pH buffers due to curcumin protonation. The influence of the temperature, pH, and buffer concentration on the extraction
yield were investigated in detail by means of a series of designed experiments. Optimized conditions for the extraction of
curcumin from turmeric by PHWE were estimated at 197 °C using 62 g/L buffer concentration at pH 1.6. The relationships between
these variables were subjected to statistical analysis using response surface methodology. 相似文献
985.
Capriotti AL Caracciolo G Cavaliere C Crescenzi C Pozzi D Laganà A 《Analytical and bioanalytical chemistry》2011,401(4):1195-1202
The knowledge about the interaction between plasma proteins and nanocarriers employed for in vivo delivery is fundamental
to understand their biodistribution. Protein adsorption onto nanoparticle surface (protein corona) is strongly affected by
vector surface characteristics. In general, the primary interaction is thought to be electrostatic, thus surface charge of
carrier is supposed to play a central role in protein adsorption. Because protein corona composition can be critical in modifying
the interactive surface that is recognized by cells, characterizing its formation onto lipid particles may serve as a fundamental
predictive model for the in vivo efficiency of a lipidic vector. In the present work, protein coronas adsorbed onto three
differently charged cationic liposome formulations were compared by a shotgun proteomic approach based on nano-liquid chromatography–high-resolution
mass spectrometry. About 130 proteins were identified in each corona, with only small differences between the different cationic
liposome formulations. However, this study could be useful for the future controlled design of colloidal drug carriers and
possibly in the controlled creation of biocompatible surfaces of other devices that come into contact with proteins into body
fluids. 相似文献
986.
Asensio-Ramos M D'Orazio G Hernandez-Borges J Rocco A Fanali S 《Analytical and bioanalytical chemistry》2011,400(4):1113-1123
In this work, the simultaneous separation of a group of 12 pesticides (carbaryl, fensulfothion, mecoprop, fenamiphos, haloxyfop,
diclofop, fipronil, profenofos, fonofos, disulfoton, nitrofen, and terbufos) by nano-liquid chromatography with UV detection
is described. For the analyses, a 100 μm internal diameter capillary column packed with silica modified with phenyl groups
was used. Experimental parameters, including the use of a trapping column for increasing the sensitivity, were optimized and
validated. A preliminary study of the applicability of a rapid and practical dispersive solid-phase extraction (DSPE) procedure
was developed for the extraction of some of these pesticides (carbaryl, fensulfothion, fenamiphos, fipronil, profenofos, fonofos,
disulfoton, nitrofen, and terbufos) from Milli-Q water samples using multi-walled carbon nanotubes (MWCNTs). The method was
validated through a recovery study at three different levels of concentration, obtaining limits of detection in the range
0.016–0.067 μg/L (below European Union maximum residue limits) for the majority of the pesticides. In this work, MWCNTs were
reused up to five times, representing an important reduction of the waste of stationary phase. Furthermore, DSPE permitted
a clear diminution of the total sample treatment time with respect to conventional SPE. 相似文献
987.
Anna Ja?kiewicz Andrzej S. Nowak 《Journal of Mathematical Analysis and Applications》2011,378(2):450-462
In this paper, we study discounted Markov decision processes on an uncountable state space. We allow a utility (reward) function to be unbounded both from above and below. A new feature in our approach is an easily verifiable rate of growth condition introduced for a positive part of the utility function. This assumption, in turn, enables us to prove the convergence of a value iteration algorithm to a solution to the Bellman equation. Moreover, by virtue of the optimality equation we show the existence of an optimal stationary policy. 相似文献
988.
We obtain a generalization of the Kodaira-Morrow stability theorem for cosymplectic structures. We investigate cosymplectic
geometry on Lie groups and on their compact quotients by uniform discrete subgroups. In this way we show that a compact solvmanifold
admits a cosymplectic structure if and only if it is a finite quotient of a torus. 相似文献
989.
In a previous paper (Kasangian and Labella, J Pure Appl Algebra, 2009) we proved a form of Conduché’s theorem for LSymcat-categories, where L was a meet-semilattice monoid. The original theorem was proved in Conduché (CR Acad Sci Paris 275:A891–A894, 1972) for ordinary categories. We showed also that the “lifting factorisation condition” used to prove the theorem is strictly
related to the notion of state for processes whose semantics is modeled by LSymcat-categories. In this note we resume the content of Kasangian and Labella (J Pure Appl Algebra, 2009) in order to generalise the theorem to other situations, mainly arising from computer science. We will consider PSymcat-categories, where P is slightly more general than a meet-semilattice monoid, in which the lifting factorisation condition for a PSymcat-functor still implies the existence of a right adjoint to its corresponding inverse image functor. 相似文献
990.
Lucas R Gómez-Pinto I Aviñó A Reina JJ Eritja R González C Morales JC 《Journal of the American Chemical Society》2011,133(6):1909-1916
Carbohydrate-nucleic acid contacts are known to be a fundamental part of some drug-DNA recognition processes. Most of these interactions occur through the minor groove of DNA, such as in the calicheamicin or anthracycline families, or through both minor and major groove binders such as in the pluramycins. Here, we demonstrate that carbohydrate-DNA interactions are also possible through sugar capping of a DNA double helix. Highly polar mono- and disaccharides are capable of CH/π stacking onto the terminal DNA base pair of a duplex as shown by NMR spectroscopy. The energetics of the carbohydrate-DNA interactions vary depending on the stereochemistry, polarity, and contact surface of the sugar involved and also on the terminal base pair. These results reveal carbohydrate-DNA base stacking as a potential recognition motif to be used in drug design, supramolecular chemistry, or biobased nanomaterials. 相似文献