全文获取类型
收费全文 | 3913篇 |
免费 | 180篇 |
国内免费 | 16篇 |
专业分类
化学 | 3148篇 |
晶体学 | 18篇 |
力学 | 52篇 |
数学 | 477篇 |
物理学 | 414篇 |
出版年
2023年 | 24篇 |
2022年 | 57篇 |
2021年 | 50篇 |
2020年 | 76篇 |
2019年 | 69篇 |
2018年 | 39篇 |
2017年 | 37篇 |
2016年 | 122篇 |
2015年 | 127篇 |
2014年 | 128篇 |
2013年 | 195篇 |
2012年 | 274篇 |
2011年 | 311篇 |
2010年 | 178篇 |
2009年 | 124篇 |
2008年 | 231篇 |
2007年 | 246篇 |
2006年 | 222篇 |
2005年 | 222篇 |
2004年 | 224篇 |
2003年 | 174篇 |
2002年 | 169篇 |
2001年 | 79篇 |
2000年 | 55篇 |
1999年 | 56篇 |
1998年 | 38篇 |
1997年 | 48篇 |
1996年 | 42篇 |
1995年 | 51篇 |
1994年 | 37篇 |
1993年 | 28篇 |
1992年 | 37篇 |
1991年 | 19篇 |
1990年 | 23篇 |
1989年 | 14篇 |
1988年 | 30篇 |
1987年 | 23篇 |
1986年 | 18篇 |
1985年 | 23篇 |
1984年 | 28篇 |
1983年 | 17篇 |
1982年 | 13篇 |
1981年 | 25篇 |
1980年 | 9篇 |
1979年 | 9篇 |
1978年 | 17篇 |
1977年 | 10篇 |
1976年 | 9篇 |
1975年 | 12篇 |
1969年 | 9篇 |
排序方式: 共有4109条查询结果,搜索用时 31 毫秒
951.
Ozturk Ozum Farouk Fathima Manaal Ooi Luyi Law Christine Shing Wei Muhammed Muhammed Tilahun Aki-Yalcin Esin Yeong Keng Yoon 《Molecular diversity》2022,26(5):2863-2876
Molecular Diversity - Selectively inhibiting butyrylcholinesterase (BChE) is hypothesized to help in the management of Alzheimer’s disease (AD). Several studies have determined a correlation... 相似文献
952.
The enormous potential of biosensors in medical diagnostics has motivated scientists to develop newer innovative tools and advance biosensing technologies. The use of cell, organelles, nucleotides, aptamers, antibodies, affibodies, proteins, peptides, molecules, and printed polymers, merged with nanotechnology, offers excellent tools to prepare highly sensitive and advanced biosensors. Therefore, the current decade has witnessed a rapid surge in the fabrication of different nanomaterial-based biosensors. Among them, carbon nanomaterials (CNMs) have emerged highly attractive in the fabrication of both electrochemical and electrochemiluminescence (ECL) biosensors. On one hand, CNMs bear prominent electrical conductivity, large surface area to immobilize adequate amount of biomolecules, an enhanced loading capacity, improved biocompatibility, and active site for electrochemical reaction. Additionally, CNMs could be chemically modified for the covalent coupling with the biomolecules. On the other hand, both electrochemical and ECL biosensors allow for cost-effective, rapid, and real-time detection with excellent sensitivity and selectivity, with the capability of integrating different biomolecules and CNMs on the same chip. However, currently there is not a single review, which includes CNM-based electrochemical and ECL biosensors' current progress and trends. Therefore, this review intends to survey the current progress and future trends in CNM-based electrochemical and ECL biosensors. 相似文献
953.
Weiwei He Louise M. A. Jakobsen Line F. Zachariassen Axel K. Hansen Henrik J. Andersen Hanne Christine Bertram 《Magnetic resonance in chemistry : MRC》2022,60(7):651-658
Currently, the existence of a gut–bone axis receives massive attention, and while sound premises and indirect proofs exist for the gut–bone axis concept, few studies have provided actual data linking the gut and bone physically. This study aimed to exploit the versatile nature of nuclear magnetic resonance (NMR) to link NMR relaxometry data on bone mineralization with NMR spectroscopic profiling of gut metabolites. For this purpose, sample material was obtained from a 6-week intervention study with ovariectomized (OVX) rats (n = 49) fed with seven different diets varying in calcium content (0.2–6.0 mg/kg) and prebiotic fiber content (0–5.0% w/w). This design ensured a span in (i) calcium available for bone mineralization and (ii) metabolic activity in the gut. After termination of the intervention, longitudinal (T1), transverse (T2) relaxation, and mechanical bone strength were measured on the excised femur bones. A PLS model with high predictability (Q2 = 0.86, R2 = 0.997) was demonstrated between T2 decay curves and femur mechanical strength. Correlations were established between bone T2 populations and gut short-chain fatty acids. In conclusion, the present dual NMR approach showed strong correlation between T2 relaxation and mechanical strength of the bone, and when metabolic activity in the gut was modulated by inulin, the potential existence of a gut–bone axis was demonstrated. 相似文献
954.
AbstractThe focus of this work is to extract a natural dye for colouring camel wool as a substitute for synthetic dyes used in the Sadu House of Kuwait. Their target is to keep the tradition of tent and rug production natural in all its manifestations. Therefore, our task was to find an abundant source that provides a colour preferably red to purple. Hibiscus rosa sinensis (HRS) is an abundantly available plant in Kuwait that was explored for extraction of the red dye to colour camel wool permanently. The powdered petals of red flowers of HRS was extracted with 5% acetic acid which yielded a deep red colour that showed a great potential for woollen fibre dyeing. The use of mordants like alum and some metal salts manifested a wide range of fixed colours which intensified at 85 °C. The colours produced had excellent fastness and was accepted by the Sadu House. 相似文献
955.
956.
Claudia Schremmer Dr. Claudia Cordes Dr. Iris Klawitter Dr. Marie Bergner Dr. Christine E. Schiewer Dr. Sebastian Dechert Dr. Serhiy Demeshko Dr. Michael John Prof. Dr. Franc Meyer 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(15):3918-3929
Starting from their six-coordinate iron(II) precursor complexes [L8RFe(MeCN)]2+, a series of iron(III) complexes of the known macrocyclic tetracarbene ligand L8H and its new octamethylated derivative L8Me, both providing four imidazol-2-yliden donors, were synthesized. Several five- and six-coordinate iron(III) complexes with different axial ligands (Cl−, OTf−, MeCN) were structurally characterized by X-ray diffraction and analyzed in detail with respect to their spin state variations, using a bouquet of spectroscopic methods (NMR, UV/Vis, EPR, and 57Fe Mößbauer). Depending on the axial ligands, either low-spin (S=1/2) or intermediate-spin (S=3/2) states were observed, whereas high-spin (S=5/2) states were inaccessible because of the extremely strong in-plane σ-donor character of the macrocyclic tetracarbene ligands. These findings are reminiscent of the spin state patterns of topologically related ferric porphyrin complexes. The ring conformations and dynamics of the macrocyclic tetracarbene ligands in their iron(II), iron(III) and μ-oxo diiron(III) complexes were also studied. 相似文献
957.
958.
Horizontal collaboration among shippers is gaining traction as a way to increase logistic efficiency. The total distribution cost of a logistic coalition is generally between 9% and 30% lower than the sum of costs of each partner distributing separately. However, the coalition gain is highly dependent on the flexibility that each partner allows in its delivery terms. Flexible delivery dates, flexible order sizes, order splitting rules, etc., allow the coalition to exploit more opportunities for optimization and create better and cheaper distribution plans. 相似文献
959.
Moran CH Rycenga M Zhang Q Xia Y 《The journal of physical chemistry. C, Nanomaterials and interfaces》2011,115(44):21852-21857
In this work, we used surface-enhanced Raman scattering (SERS) to monitor the replacement of poly(vinyl pyrrolidone) (PVP) on Ag nanocubes by cysteamine, thiol-terminated PEG, and benzenedithiol. PVP is widely used as a colloidal stabilizer and capping agent to control the shape of Ag (as well as many other noble metals) nanocrystals during synthesis, and to stabilize the final colloidal suspension. However, the surface chemistry of Ag nanocrystals often needs to be tailored for specific applications, so the PVP coating must be removed and/or replaced by other ligands. By monitoring the signature peak from the carbonyl groups of PVP, we show, for the first time, that the PVP adsorbed on the surface of Ag nanocubes was completely replaced by the thiol molecules at room temperature over the course of a few hours. We observed the same trend no matter if the Ag nanocubes were suspended in an aqueous solution of the thiol or supported on a silicon substrate and then immersed in the thiol solution. 相似文献
960.
Jonas Verhoeven Freija De Vleeschouwer Hanchu Kong Prof. Kristof Van Hecke Vineet Pande Weimei Sun Ann Vos Tongfei Wu Lieven Meerpoel Jan Willem Thuring Guido Verniest 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(67):15419-15423
Despite the large variety of modified nucleosides that have been reported, the preparation of constrained 4′-spirocyclic adenosine analogues has received very little attention. We discovered that the [2+2]-cycloaddition of dichloroketene on readily available 4′-exo-methylene furanose sugars efficiently results in the diastereoselective formation of novel 4′-spirocyclobutanones. The reaction mechanism was investigated via density functional theory (DFT) and found to proceed either via a non-synchronous or stepwise reaction sequence, controlled by the stereochemistry at the 3′-position of the sugar substrate. The obtained dichlorocyclobutanones were converted into nucleoside analogues, providing access to a novel class of chiral 4′-spirocyclobutyl adenosine mimetics in eight steps from commercially available sugars. Assessment of the biological activity of designed 4′-spirocyclic adenosine analogues identified potent inhibitors for protein methyltransferase target PRMT5. 相似文献