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231.
Urszula Domańska Aneta Pobudkowska Aleksandra Pelczarska Magdalena Winiarska-Tusznio Paweł Gierycz 《The Journal of chemical thermodynamics》2010,42(12):1465-1472
Solubilities of six pharmaceuticals, namely nadolol, atenolol, bifonazole, nimesulide, estrone, mefenamic acid at constant pH, were measured over the range of temperature from (240 to 340) K in three important for drug solvents: water, ethanol, and 1-octanol using the dynamic method and spectroscopic UV–Vis method. Dissociation constants and corresponding pKa values of the drugs were obtained with the Bates–Schwarzenbach method using UV–Vis Perkin–Elmer Lambda 35 Spectrophotometer at temperature 298.15 K in the buffer solutions. Our experimental pKa values for nadolol, bifonazole, nimesulide, and mefenamic acid are 9.3, 5.85, 7.34, and 3.88, respectively. The basic thermal properties of pure drugs i.e. fusion and glass-transition temperatures, as well as the enthalpy of fusion and the molar heat capacity at the glass-transition (at constant pressure) have been measured using the differential scanning microcalorimetry technique (DSC). Molar volumes have been calculated with the Barton group contribution method. The experimental solubility results have been correlated by means of three commonly known GE equations: the Wilson, NRTL, and UNIQUAC with the assumption that the systems studied here are simple eutectic mixtures. The activity coefficients of pharmaceuticals in saturated solutions in each correlated binary mixture were calculated from the experimental results. Prediction of solubility in water at T = 298.15 K was made by the group contribution method. 相似文献
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233.
JPC – Journal of Planar Chromatography – Modern TLC - Phenolic acids in the leaves, roots, and fruits of Peucedanum verticillare L. Koch ex Dc have been qualitatively determined for the... 相似文献
234.
Aleksandra Konopacka Joanna Pająk Aneta Jezierska Jarosław Panek Riet Ramaekers Guido Maes Zbigniew Pawełka 《Structural chemistry》2006,17(2):177-188
Experimental and theoretical studies were carried out in order to investigate the rotational isomerism of terephthalaldehyde. The dipole moment measurements and infrared spectroscopy in Ar matrix and using various solvents were performed experimentally. In order to supplement the experimental study, both static and dynamical theoretical calculations were performed. IR spectra and potential energy distribution (PED) were calculated for both cis and trans isomers of terephthalaldehyde in gas phase using B3LYP/6-31G(d,p) level of theory. Further calculations consisted of conformational analysis were performed in order to estimate the rotational barrier and relative stabilities of isomers. The DFT theory with B3LYP functional and four double-zeta and triple-zeta basis sets served as framework for this part of calculations. Semiempirical AM1 and PM3 methods were also used for gas-phase modeling. Molecular dynamics using MM3 force field was applied to study the preferences of solvent molecules’ orientation around the studied molecule. Additionally, the effect of solvent polarity on the Gibbs energy of the trans ⇌ cis equilibrium was analyzed in terms of the continuum dielectric medium models. 相似文献
235.
Anna Migda?-Mikuli Edward Mikuli Aneta Kowalska 《Journal of solid state chemistry》2004,177(8):2733-2739
[Ni(ND3)6](ClO4)2 has three solid phases between 100 and 300 K. The phase transitions temperatures at heating (TC1h=164.1 K and TC2h=145.1 K) are shifted, as compared to the non-deuterated compound, towards the lower temperature of ca. 8 and 5 K, respectively. The ClO4− anions perform fast, picosecond, isotropic reorientation with the activation energy of 6.6 kJ mol−1, which abruptly slow down at TC1c phase transition, during sample cooling. The ND3 ligands perform fast uniaxial reorientation around the Ni-N bond in all three detected phases, with the effective activation energy of 2.9 kJ mol−1. The reorientational motion of ND3 is only slightly distorted at the TC1 phase transition due to the dynamical orientational order-disorder process of anions. The low value of the activation energy for the ND3 reorientation suggests that this reorientation undergoes the translation-rotation coupling, which makes the barrier to the rotation of the ammonia ligands not constant but fluctuating. The phase polymorphism and the dynamics of the molecular reorientations of the title compound are similar but not quite identical with these of the [Ni(NH3)6](ClO4)2. 相似文献
236.
The photochemical or thermal decomposition of ethyl diazomalonate (1) or ethyl 3,3-diazirinedicarboxylate in methanol solutions yields the O-H insertion product 6, while products of the Wolff rearrangement were not detected in both cases. The analysis of temperature-dependent (13)C NMR spectra and the results of DFT B3LYP/6-311+G(3df,2p) and MP2/aug-cc-pVTZ//B3LYP/6-311+G(3df,2p) calculations allow us to conclude that diazodiester 1 predominantly exists in the Z,Z-conformation. In contrast, photolysis of the cyclic isopropylidene diazomalonate (3), which also has a Z,Z-configuration of the diazodicarbonyl moiety, results in a clean Wolff rearrangement. These observations allow us to conclude that the direction of the photodecomposition of diazomalonates is not controlled by the ground-state conformation. The quantum-mechanical analysis of the potential energy surfaces for the dediazotization of 1 and 3 suggests that the formation of a carbene as a discrete intermediate is controlled by the ability of the latter to adopt a conformation in which carbonyl groups are almost orthogonal to the carbene plane. The outcome of the photolysis of ethyl diazomalonate depends on the wavelength of irradiation. Irradiation with 254 nm light results in the loss of nitrogen and the formation of dicarboethoxycarbene (5, Phi(254) = 0.31), while at longer wavelengths, diazirine 2 becomes an important byproduct (Phi(350) = 0.09). This observation suggests that the formation of carbene 5 and isomerization to diazirine proceed from different electronically excited states of ethyl diazomalonate. 相似文献
237.
Krystyna Wejroch Jerzy Lange Aneta Wesoowska Tadeusz Jagodzi Ski Maja Sadowska Janina Karolak‐Wojciechowska 《Journal of heterocyclic chemistry》2005,42(5):919-924
Some intermediates and by‐products of the title reaction, known to yield 6‐hydrazinopyridazine‐3‐one derivatives, were isolated or detected when the amount of hydrazine hydrate used to react with two model β‐cyano esters was reduced to less than two equivalents. N'‐(1‐amino‐4‐hydrazino‐4‐oxo‐2‐phenylbutyli‐dene)‐4‐hydrazino‐4‐oxo‐2‐phenylbutanehydrazonamide and 3,3,8,8‐tetramethyl‐2,3,7,8‐tetrahydro‐1H,6H‐dipyrrolo[1,2‐b:1′,2′‐e][1,2,4,5]tetrazine‐1,6‐dione were isolated as the terminal products of side‐reactions; they were unreactive to hydrazine. The latter compound is a derivative of a novel ring system. Mechanism of the reaction was proposed. 相似文献
238.
Karnicka K Chojak M Miecznikowski K Skunik M Baranowska B Kolary A Piranska A Palys B Adamczyk L Kulesza PJ 《Bioelectrochemistry (Amsterdam, Netherlands)》2005,66(1-2):79-87
We develop a concept of fabrication of the multilayer network films on electrodes by exploring the ability of a Keggin-type polyoxometallate, phosphododecamolybdate (PMo(12)O(40)(3-)), to form stable anionic monolayers (templates) on carbon and metals including platinum. By repeated alternate treatments in the solution of PMo(12)O(40)(3-) (or in the colloidal suspension of polyoxometallate-protected Pt-nanoparticles) and in the solution of monomer (e.g. anilinium) cations, the amount of the material can be increased systematically (layer-by-layer) to form stable three-dimensional assemblies on electrode (e.g. glassy carbon) surfaces. In the resulting hybrid (organic-inorganic) films, the layers of negatively charged polyoxometallate, or polyoxometallate-protected (stabilized) Pt-nanoparticles, are linked or electrostatically attracted by ultra-thin layers of such positively charged conducting polymers as polyaniline (PANI), polypyrrole (PPy) or poly(3,4-ethylenedioxythiophene), PEDOT. Consequently, the attractive physicochemical properties of polymers and reactivity of polyoxometallate or noble metal particles are combined. The films are functionalized and show electrocatalytic properties towards reduction of nitrite, bromate, hydrogen peroxide or oxygen. They are of importance to the chemical and biochemical sensing as well as to the biochemical and medical applications. 相似文献
239.
A new strategy based on the use of diethylamine triazenes for stabilization and generation of polymer supported diazonium ions was described. New economical syntheses of four new polymeric supports with 3- and 6-carbon atom spacers and triazene linkers derived from meta- and para-aminophenol were described and compared to the traditional methods. The possible application of the polymer bound triazene masked diazonium salts as supports for immobilization of secondary amines (nortropine and 4-piperidinole and their esterification and oxidation), and as amine scavengers was shown. The new supports with meta-C3-T2 and para-C3-T2 linkers showed higher loadings and typically gave products with good yields and purities. 相似文献
240.
The photochemical or thermal decomposition of diazo Meldrum's acid (1) in methanolic solutions yields ketoester 3a, the product of the Wolff rearrangement, while products produced from the singlet carbene were not detected. This observation, combined with the analysis of activation parameters for the thermal decomposition of 1, as well as with the results of DFT B3PW91/6-311+G(3df,2p) and MP2/aug-cc-pVTZ//B3PW91/6-311+G(3df,2p) calculations, allows us to conclude that the Wolff rearrangement of 1 is a concerted process. The outcome of the photolysis of diazo Meldrum's acid depends on the wavelength of irradiation. Irradiation with 254 nm light results in an efficient (Phi(254) = 0.34) photo-Wolff reaction, while at 355 nm, the formation of diazirine 2 becomes the predominant process (Phi(350) = 0.024). This unusual wavelength selectivity indicates that Wolff rearrangement and isomerization originate from different electronically excited states of 1. The UV irradiation of diazirine 2 leads to the loss of nitrogen and the Wolff rearrangement, apparently via a carbene intermediate. This process is accompanied by a reverse isomerization to diazo Meldrum's acid. Triplet-sensitized photolysis of both isomers results in the formation of Meldrum's acid, the product of a formal reduction of 1 and 2. Mild heating of diazirine 2 produces quantitative yields of diazo Meldrum's acid. The activation parameters for thermal reactions of diazo 1 and diazirino 2 isomers were determined in aqueous and dioxane solutions. 相似文献