Synthesis,spectral characterization,theoretical, antimicrobial,DNA interaction and in vitro anticancer studies of Cu(II) and Zn(II) complexes with pyrimidine-morpholine based Schiff base ligand

Novel Cu(II) (1) and Zn(II) (2) complexes with 4-(1-(4-morpholinophenyl)ethylideneamino)pyrimidine-5-carbonitrile) (L) have been synthesized and characterized by various spectroscopic and analytical techniques. DFT (density functional theory) studies result confirms that, LMCT mechanism have been done between L and M(II) ions. The antimicrobial studies indicate that the ligand L and complexes 1 & 2 exhibit higher activity against the E. coli bacteria and C. albicans fungi. The groove binding mode of ligand L and complexes 1 & 2 with CT-DNA have been confirmed by electronic absorption, competitive binding, viscometric and cyclic voltammetric studies. The electronic absorption titration of ligand L and complexes 1 & 2 with DNA have been carried out in different buffer solutions (pH 4.0, 7.0 & 10.0). The K_b values of ligand L and complexes 1 & 2 are higher in acidic buffer at pH 4.0 (K_b = 2.42 × 10⁵, L; 2.8 × 10⁵, 1; 2.65 × 10⁵, 2) and the results revealed that, the interaction of synthesized compounds with DNA were higher in the acidic medium than basic and neutral medium. Furthermore, CT-DNA cleavage studies of ligand L and complexes 1 & 2 have been studied. The in vitro anticancer activities results show that complexes 1 & 2 have moderate cytotoxicity against cancer cell lines and low toxicity on normal cell line than ligand L.     

Measurement of K,Fe, Cu and Zn levels in secondary colorectal liver cancer and surrounding normal liver tissue,and their potential as a tissue classifier

An x‐ray fluorescence (XRF) system utilising a synchrotron radiation source was used to quantify the levels of Fe, Cu, Zn and K in colorectal liver metastases and surrounding normal liver tissue as a possible mechanism for detecting cancer in a tissue biopsy. Sixty samples were measured and a lower level of all four elements was found in the cancer samples compared with that of the normal liver. The difference in levels of Zn, Fe, Cu and K between cancer and normal tissue was significant with p values of < 0.01 for Zn, Fe and K, and 0.033 for Cu. The precision was estimated by repeated measurements yielding a precision of 96, 91, 95 and 86% for Zn, Cu, Fe and K, respectively. The homogeneity of the distribution of elemental concentrations was assessed by measuring eight normal liver and eight cancer samples from the same patient. The variation of Zn, Cu, Fe and K levels between normal liver samples was 10.4, 15.4, 15.85 and 29.1%, respectively, and in the colorectal metastases was 10.18, 15.92, 8.44 and 22.35%, respectively. Receiver operator characteristic (ROC) analysis was performed for all elements and showed that Zn could be a reliable indicator of tissue classification with an ROC area under the curve of 0.998 and a resulting sensitivity and specificity of 100 and 96.67%, respectively. Fe had an ROC area under the curve of 0.856 and sensitivity and specificity of 83.3 and 76.67%, respectively. Cu and K did not perform as well with areas under the curve of 0.75 and 0.706, respectively. Copyright © 2008 John Wiley & Sons, Ltd.     

On the injectivity of twisted spherical means on ℂ n

In this paper we study the injectivity and injectivity sets for the twisted spherical means on ℂ ⁿ . These results are then used to study the same problems on the reduced Hiesenberg group.     

Defect-enriched heterointerfaces N–MoO2–Mo2C supported Pd nanocomposite as a novel multifunctional electrocatalyst for oxygen reduction reaction and overall water splitting

Developing highly efficient, cost-saving, and durable multifunctional electrocatalysts for oxygen evolution reaction (OER), oxygen reduction reaction (ORR), and hydrogen evolution reaction (HER) continues to be a significant challenge in the energy field. In this work, we decide to prepare an unusual multifunctional electrocatalyst, such as icosahedral palladium nanocrystals (PdNCs) encapsulating on N–MoO₂–Mo₂C half-hollow nanotube (HHNT) heterointerface, using an in-situ chemical reaction and following sonic probe irradiation method. All the experiments demonstrate that special defect-enriched heterointerfaces N–MoO₂–Mo₂C supported Pd nanocomposite can greatly improve the ORR activity (E_onset = 1.01 V and E_1/2 = 0.90 V) with good stability, outstanding HER (η₁₀ = 65 mV) and OER (η₁₀ = 180 mV) performances than those of commercial precious electrocatalysts (Platinum on carbon [Pt/C] and ruthenium oxide [RuO₂]). The overall water splitting electrolyzer fabricates by Pd/N–MoO₂–Mo₂C as both anode and cathode electrodes to achieve a current density of 10 Ma/cm² at a cell voltage of 1.56 V, which surpasses the most recent reported electrocatalysts.     

Characterization of ligno-cellulosic seed fibre from Wrightia Tinctoria plant for textile applications—an exploratory investigation

A hitherto uninvestigated ligno-cellulosic seed fibre from the plant Wrightia Tinctoria has been chosen for the current study to unravel its physical properties, and potentialities in textile applications. Both raw and partially delignified fibres were tested for their morphological and structural features by X-ray diffraction, optical microscope and FT-IR spectra, thermal properties by thermogravimetry and differential scanning calorimetry and fibre fineness properties. The non-spinnable brittle virgin fibre becomes spinnable after partial delignification due to the decreased fibre rigidity imparted by lignin. Knitted fabrics were made successfully with (20%) and without cotton blending.     

The nonlinear optical properties of a magneto-exciton in a strained Ga_(0.2)In_(0.8)As/GaAs quantum dot

The magnetic field-dependent heavy hole excitonic states in a strained Ga0.2In0.8As/GaAs quantum dot are investigated by taking into account the anisotropy,non-parabolicity of the conduction band,and the geometrical confinement.The strained quantum dot is considered as a parabolic dot of InAs embedded in a GaAs barrier material.The dependence of the effective excitonic g-factor as a function of dot radius and the magnetic field strength is numerically measured.The interband optical transition energy as a function of geometrical confinement is computed in the presence of a magnetic field.The magnetic field-dependent oscillator strength of interband transition under the geometrical confinement is studied.The exchange enhancements as a function of dot radius are observed for various magnetic field strengths in a strained Ga0.2In0.8As/GaAs quantum dot.Heavy hole excitonic absorption spectra,the changes in refractive index,and the third-order susceptibility of third-order harmonic generation are investigated in the Ga0.2In0.8As/GaAs quantum dot.The result shows that the effect of magnetic field strength is more strongly dependent on the nonlinear optical property in a low-dimensional semiconductor system.     

Copper(II), nickel(II), cobalt(II) and oxovanadium(IV) complexes of 1-(3-hydroxy-2-naphthyl)-5-(p-X-phenyl)pent-4-ene-1,3-diones

Complexes of 1-(3-hydroxy-2-naphthyl)-5-(p-X-phenyl)pent-4-ene-1, 3-diones (HXNP) (X = H, Cl, Me or OMe) with divalent metal ions, having the formula M(HXNP)2 (M = Cu, Ni or Co) and M(HXNP)2 · nB (n = 0,2: B = H2O or Py), have been prepared and characterized by elemental analyses, i.r., electronic, 1H-n.m.r. and e.s.r. spectroscopies and by magnetic susceptibility measurements. Spectral assignments show the metal ions to be coordinated through both carbonyl oxygen atoms and the effect of conjugation of the ligand structure (d–* interaction) is strong enough to stabilize the metal ligand bond. The observed hyperfine splitting constants and magnetic moments suggest that the copper complexes are monomers with a slightly distorted planar structure, having more covalent in plane -bonding. The magnetic and spectral properties of the dihydrates and dipyridinates of the cobalt and nickel complexes are commensurate with monomeric high-spin octahedral geometries; polymerization takes place on dehydration–depyridination of nickel(II) complexes. Oxovanadyl complexes of these -diketones have also been prepared; the ligand-to-metal ratio is 2:1 with square pyramidal geometry. The e.s.r. spectra of the complexes show the presence of one unpaired electron in the dxy orbital and the hyperfine splitting constants are sensitive to a change in solvent. The effect of bases on the redox behaviour of copper(II) complexes owing to geometry change is discussed.     

Oscillating multipliers for some eigenfunction expansions

Let P be a non-negative, self-adjoint differential operator of degree d on ℝⁿ. Assume that the associated Bochner-Riesz kernel s _R ^δ satisfies the estimate, |s _R ^δ (x, y)| ≤ C R^n/d(1+R^1/d|x - y|^-αδ+β)for some fixed constants a>0 and β. We study L^p boundedness of operators of the form m(P), m coming from the symbol class S _p ^−α . We prove that m(P) is bounded on L^P if . We also study multipliers associated to the Hermite operator H on ℝⁿ and the special Hermite operator L on ℂⁿ given by the symbols . As a special case we obtain L^p boundedness of solutions to the Wave equation associated to H and L.