排序方式: 共有54条查询结果,搜索用时 31 毫秒
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Anat Reiner-Benaim 《Methodology and Computing in Applied Probability》2016,18(3):717-745
A scan statistic is examined for the purpose of testing the existence of a global peak in a random process with dependent variables of any distribution. The scan statistic tail probability is obtained based on the covariance of the moving sums process, thereby accounting for the spatial nature of the data as well as the size of the searching window. Exact formulas linking this covariance to the window size and the correlation coefficient are developed under general, common and auto covariance structures of the variables in the original process. The implementation and applicability of the formulas are demonstrated on multiple processes of t-statistics, treating also the case of unknown covariance. A sensitivity analysis provides further insight into the variant interaction of the tail probability with the influence parameters. An R code for the tail probability computation and the data analysis is offered within the supplementary material. 相似文献
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Dr. Yaron Bram Ayala Lampel Dr. Ronit Shaltiel‐Karyo Anat Ezer Dr. Roni Scherzer‐Attali Prof. Dr. Daniel Segal Prof. Dr. Ehud Gazit 《Angewandte Chemie (International ed. in English)》2015,54(7):2062-2067
Amyloid deposits are pathological hallmark of a large group of human degenerative disorders of unrelated etiologies. While accumulating evidence suggests that early oligomers may account for tissue degeneration, most detection tools do not allow the monitoring of early association events. Here we exploit bimolecular fluorescence complementation analysis to detect and quantify the dimerization of three major amyloidogenic polypeptides; islet amyloid polypeptide, β‐amyloid and α‐synuclein. The constructed systems provided direct visualization of protein‐protein interactions in which only assembled dimers display strong fluorescent signal. Potential inhibitors that interfere with the initial intermolecular interactions of islet amyloid polypeptide were further identified using this system. Moreover, the identified compounds were able to inhibit the aggregation and cytotoxicity of islet amyloid polypeptide, demonstrating the importance of targeting amyloid dimer formation for future drug development. 相似文献
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Anat Levi-Zada Daniela FeferLeonid Anshelevitch Anna LitovskyMarie Bengtsson Galina GindinVictoria Soroker 《Tetrahedron letters》2011,52(35):4550-4553
The identification of the sex pheromone of the lesser date moth, Batrachedra amydraula (Meyrick) was based on GC-MS analysis of volatiles released by virgin females using sequential SPME auto-sampling of headspace and by synthesis of the key component, (4Z,7Z)-4,7-decadien-1-yl acetate. Substantial capture of males in a date palm plantation using a bait consisting of the key component and 5Z-decen-1-yl acetate in a ratio of 1:2 indicated that these are the essential components of the sex pheromone. Addition of 4Z-decen-1-yl acetate and decan-1-yl acetate, which were also identified, did not affect trap-capture. The lesser date moth is the first member of the Batrachedridae whose sex pheromone has been identified. (4Z,7Z)-4,7-Decadien-1-yl acetate is a novel compound among moth sex pheromones. 相似文献
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In this paper, we present the concept of a soluble tubular conjugated polymer (TCP). We report on a fluorescent 5,5'-Bicalixarene-based polymer where the calixarene units are seamlessly incorporated in the conjugated polymeric chain that can respond to a small molecule complexation inside the hydrophobic cavity. In particular, our system demonstrated a reversible rapid fluorescence quenching upon interaction of gaseous nitric oxide with the calixarene moiety. 相似文献
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Current challenges in compound-specific stable isotope analysis of environmental organic contaminants 总被引:3,自引:0,他引:3
Elsner M Jochmann MA Hofstetter TB Hunkeler D Bernstein A Schmidt TC Schimmelmann A 《Analytical and bioanalytical chemistry》2012,403(9):2471-2491
Compound-specific stable-isotope analysis (CSIA) has greatly facilitated assessment of sources and transformation processes of organic pollutants. Multielement isotope analysis is one of the most promising applications of CSIA because it even enables distinction of different transformation pathways. This review introduces the essential features of continuous-flow isotope-ratio mass spectrometry (IRMS) and highlights current challenges in environmental analysis as exemplified for the isotopes of nitrogen, hydrogen, chlorine, and oxygen. Strategies and recent advances to enable isotopic measurements of polar contaminants, for example pesticides or pharmaceuticals, are discussed with special emphasis on possible solutions for analysis of low concentrations of contaminants in environmental matrices. Finally, we discuss different levels of calibration and referencing and point out the urgent need for compound-specific isotope standards for gas chromatography-isotope-ratio mass spectrometry (GC-IRMS) of organic pollutants. 相似文献
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Michaela Ritter Anat Molad Varun Rawat Christian Limberg 《Supramolecular chemistry》2014,26(7-8):530-537
The synthesis and characterisation of an asymmetrically substituted calix-triazole ligand are reported. The ligand reacts with the Fe(II) precursor Fe2Mes4 to yield an iron(II) calixarene complex that is oxidised by dioxygen to provide a dinuclear Fe(III) compound featuring an oxido bridge. 相似文献
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Lipovsky A Levitski L Tzitrinovich Z Gedanken A Lubart R 《Photochemistry and photobiology》2012,88(1):14-20
Photoexcited TiO(2) has been found to generate reactive oxygen species, yet the precise mechanism and chemical nature of the generated oxy species especially regarding the different crystal phases remain to be elucidated. Visible light-induced reactions of a suspension of titanium dioxide (TiO(2)) in water were investigated using electron paramagnetic resonance (EPR) coupled with the spin-trapping technique. Increased levels of both hydroxyl (˙OH) and superoxide anion (˙O(2)(-)) radicals were detected in TiO(2) rutile and anatase nanoparticles (50 nm). The intensity of signals assigned to the ˙OH and ˙O(2)(-) radicals was larger for the anatase phase than that originating from rutile. Moreover, illumination with visible (nonUV) light enhanced ˙O(2)(-) formation in the rutile phase. Singlet oxygen was not detected in water suspension of TiO(2) neither in rutile nor in anatase nanoparticles, but irradiation of the rutile phase with visible light revealed a signal, which could be attributed to singlet oxygen formation. The blue part of visible spectrum (400-500 nm) was found to be responsible for the light-induced ROS in TiO(2) nanoparticles. The characterization of the mechanism of visible light-induced oxy radicals formation by TiO(2) nanoparticles could contribute to its use as a sterilization agent. 相似文献
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