Non-linear response of a string to random excitation

The mean square deflection of a non-linear string subjected to nonplanar Gaussian white noise excitation is determined by the perturbation method. It is shown that increase in tension due to stretching, and transverse transverse mode coupling tend to reduce the mean square deflection; while longitudinal-transverse mode coupling tends to counter this effect to some extent. These results are in conformity with the trend observed in the case of periodic excitation.     

Double shearography for engineering metrology: optical and digital approach

This paper presents a double shearographic configuration based on the optical method by using two Michelson interferometers in tandem. The problems associated with the extraction of second order derivatives by optical means and a comparison with the proposed novel approach by digital means are discussed in this paper.     

Advantages of endoscopic laser arytenoidectomy using yag laser scalpel

The surgical management of bilateral vocal cord paralysis has been performed through an endoscope in the past. The etiology of bilateral vocal cord paralysis is usually secondary to trauma; to secure an adequate airway, a tracheostomy is performed. Endoscopic laser arytenoidectomy offers a safe method of decannulating patients with maintenance of good voice quality and a rima glottidis of 4–6 mm posteriorly. Several wavelengths are available to carry out this procedure, and this article will focus on Nd:Yag laser scalpel applications. The advantage of this method is the preservation of good voice quality with an option of an external procedure, if the need arises. The laser application offers excellent hemostasis, and decreased edema and scar tissue formation. The results of our study on 10 patients appear encouraging and superior with respect to other available wavelengths.     

A tandem mass spectrometric approach to the identification of O‐glycosylated glargine glycoforms in active pharmaceutical ingredient expressed in Pichia pastoris

Glycoforms of glargine expressed in Pichia pastoris were isolated by high‐performance liquid chromatography and analyzed by a series of chemical and mass spectrometric methods for the identification of various glycoforms, glycosylation position, nature and structure of glycans. Reduction and alkylation, peptide mapping techniques were used to decipher the amino acid site at which glycosylation had taken place. Chemical methods were coupled with mass spectrometry techniques such as electrospray ionization and matrix‐assisted laser desorption/ionization for identification of the glycosylation site. Copyright © 2009 John Wiley & Sons, Ltd.     

Initiation of localized shear bands in plane strain

This study is concerned with the initiation of localized shear bands in plane-strain tension and compression. A theoretical framework which views the initiation of such shear bands as a bifurcation phenomenon from a homogeneous equilibrium field in an elastic-plastic body is first briefly reviewed, and then the predictions of the theory are compared with some experimental observations on an aged maraging steel. The experiments support the physical relevance of the theory within the framework of continuum mechanics.Specifically, the comparison between theory and experiment is concerned with the critical strains to localization and the orientation of the shear bands relative to the load axis. The theoretical predictions are only in qualitative agreement with the experimental observations. A better agreement is obtained with use of the constitutive equations corresponding to the classical deformation theory (a simple vertex model) than with use of the constitutive equations of the classical flow theory. It is concluded that better constitutive equations for elastic-plastic materials are needed before theoretical predictions can be obtained which might be expected to be in closer quantitative accord with experiment.