全文获取类型
收费全文 | 16135篇 |
免费 | 2271篇 |
国内免费 | 2308篇 |
专业分类
化学 | 12833篇 |
晶体学 | 290篇 |
力学 | 625篇 |
综合类 | 197篇 |
数学 | 1910篇 |
物理学 | 4859篇 |
出版年
2024年 | 29篇 |
2023年 | 224篇 |
2022年 | 466篇 |
2021年 | 509篇 |
2020年 | 568篇 |
2019年 | 636篇 |
2018年 | 515篇 |
2017年 | 533篇 |
2016年 | 735篇 |
2015年 | 783篇 |
2014年 | 1015篇 |
2013年 | 1218篇 |
2012年 | 1432篇 |
2011年 | 1472篇 |
2010年 | 1120篇 |
2009年 | 1053篇 |
2008年 | 1261篇 |
2007年 | 1026篇 |
2006年 | 988篇 |
2005年 | 814篇 |
2004年 | 666篇 |
2003年 | 550篇 |
2002年 | 650篇 |
2001年 | 471篇 |
2000年 | 321篇 |
1999年 | 264篇 |
1998年 | 212篇 |
1997年 | 137篇 |
1996年 | 138篇 |
1995年 | 118篇 |
1994年 | 109篇 |
1993年 | 98篇 |
1992年 | 82篇 |
1991年 | 106篇 |
1990年 | 62篇 |
1989年 | 55篇 |
1988年 | 30篇 |
1987年 | 39篇 |
1986年 | 26篇 |
1985年 | 38篇 |
1984年 | 20篇 |
1983年 | 15篇 |
1982年 | 11篇 |
1981年 | 14篇 |
1980年 | 11篇 |
1979年 | 10篇 |
1978年 | 10篇 |
1977年 | 9篇 |
1976年 | 8篇 |
1971年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
941.
Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-molecule libraries. 相似文献
942.
943.
Jian Jiao Min Chen Shengxin Sun Weijie Si Xiaobin Wang Weijie Ding Xincan Fu An Wang Chunlong Yang 《中国化学》2021,(2):323-329
To screen novel antifungal agents targeting the succinate dehydrogenase(SDH),a series of pyrazole-4-carbohydrazides were rationally designed,synthesized,and characterized under the guidance of the structures of succinate dehydrogenase inhibitors(SDHIs).Bioassay results in vitro indicated that most of the target compounds exhibited excellent activity against Rhizoctonia solani(R.solani),Fusarium graminearum(F.graminearum),Botrytis cinerea(B.cinerea)and Colletotrichum capsica(C.cinerea).Compounds 7d,7l,7t and 7x were identified as the most promoting candidates,and their anti-F.graminearum EC50 values were as low as 0.56,0.47,0.46 and 0.49μg/mL,respectively,presenting the similar antifungal activity as that of the commonly used fungicide carbendazim(0.43μg/mL).The 3D-QSAR models were built for a systematic structure-activity relationship profile to explore more potent pyrazole-4-carbohydrazides as novel fungicides.Molecular docking of 7d,7l and 7r with SDH was performed to reveal the binding modes in active pocket and analyze the interactions between the molecules and the SDH protein. 相似文献
944.
Effect of Interfacial Adsorption on the Stability of Thin Polymer Films in a Solvent-induced Process
The stability of ultrathin polymer films plays a crucial role in their technological applications. Here, we systematically investigated the influence of interfacial adsorption in physical aging and the stability of thin polymer films in the solvent-induced process. We further identify the stability mechanism from the theory of thin film stability. Our results show that the aging temperature and film thickness can strongly influence the stability of thin PS films in acetone vapor. Physical aging can greatly improve the stability of thin polymer films when the aging temperature T_(aging1)T_g. A thinner PS film more quickly reaches a stable state via physical aging. At short aging time, the formation of the adsorbed layer can reduce the polar interaction; however, it slightly influences the stability of thin polymer films in the solvent-induced process. At later aging stage,the conformational rearrangement of the polymer chains induced by the interfacial effect at the aging temperature T_(aging1) plays an important role in stabilizing the thin polymer films. However, at T_(aging2)T_g, the process of physical aging slightly influences the stability of the thin polymer films.The formation of the adsorbed layer at T_(aging2) can reduce the short-range polar interaction of the thin film system and cannot suppress the instability of thin polymer films in the solvent-induced process. These results provide further insight into the stable mechanism of thin polymer films in the solvent-induced process. 相似文献
945.
Tong Wu Xiao Wang Ahmet Emrehan Emre Jinchen Fan Yulin Min Qunjie Xu Shigang Sun 《Journal of Energy Chemistry》2021,(4):48-54
Electrocatalysts for ethanol oxidation reaction(EOR)are generally limited by their poor durability because of the catalyst poisoning induced by the reaction intermediate carbon monoxide(CO).Therefore,the rapid oxidation removal of CO intermediates is crucial to the durability of EOR-based catalysts.Herein,in order to effectively avoiding the catalyst CO poisoning and improve the durability,the graphene-nickel nitride hybrids(AG-Ni3N)were designed for supporting palladium nanoparticles(Pd/AG-Ni3N)and then used for ethanol electrooxidation.The density functional theory(DFT)calculations demonstrated the introduction of AG-Ni3N depresses the CO absorption and simultaneously promotes the adsorption of OH species for CO oxidation removal.The fabricated Pd/AG-Ni3N catalyst distinctively exhibits excellent electroactivity with the mass catalytic activity of 3499.5 m A mg-1 on EOR in alkaline media,which is around 5.24 times higher than Pd/C(commercial catalyst).Notably,the Pd/AG-Ni3N hybrids display excellent stability and durability after chronoamperometric measurements with a total operation time of 150,000 s. 相似文献
946.
Zengqing Sun Qingyu Tang Xiaohui Fan Min Gan Xuling Chen Zhiyun Ji Xiaoxian Huang 《Molecules (Basel, Switzerland)》2022,27(1)
Alkali-activated materials (AAMs) are considered to be alternative cementitious materials for civil infrastructures. Nowadays, efforts have been made in developing AAMs with self-compacting ability. The obtained self-compacting AAMs (SCAAMs) accomplish superior passing and filling properties as well as excellent mechanical and environmental advantages. This work critically revisits recent progresses in SCAAMs including mixture proportions, fresh properties, mechanical strength, microstructure, acid and sulfate resistance, high temperature behaviors, impact resistance and interface shear strength. To facilitate direct comparison and interpretation of data from different publications, mixture proportions were normalized in terms of the content of key reactive components from precursors and activators, and correlation with mechanical behaviors was made. Moreover, special attention was paid to current research challenges and perspectives to promote further investigation and field application of SCAAMs as advanced construction material. 相似文献
947.
Wei Yang Anqianyi Tu Yuchen Ma Zhanming Li Jie Xu Min Lin Kailong Zhang Linzhi Jing Caili Fu Yang Jiao Lingyi Huang 《Molecules (Basel, Switzerland)》2022,27(1)
The application of chitosan (CS) and whey protein (WP) alone or in combination in 3D/4D printing has been well considered in previous studies. Although several excellent reviews on additive manufacturing discussed the properties and biomedical applications of CS and WP, there is a lack of a systemic review about CS and WP bio-inks for 3D/4D printing applications. Easily modified bio-ink with optimal printability is a key for additive manufacturing. CS, WP, and WP–CS complex hydrogel possess great potential in making bio-ink that can be broadly used for future 3D/4D printing, because CS is a functional polysaccharide with good biodegradability, biocompatibility, non-immunogenicity, and non-carcinogenicity, while CS–WP complex hydrogel has better printability and drug-delivery effectivity than WP hydrogel. The review summarizes the current advances of bio-ink preparation employing CS and/or WP to satisfy the requirements of 3D/4D printing and post-treatment of materials. The applications of CS/WP bio-ink mainly focus on 3D food printing with a few applications in cosmetics. The review also highlights the trends of CS/WP bio-inks as potential candidates in 4D printing. Some promising strategies for developing novel bio-inks based on CS and/or WP are introduced, aiming to provide new insights into the value-added development and commercial CS and WP utilization. 相似文献
948.
Lijia An Rongtang Ma Xichun Kou Xinyi Tang Bingzheng Jiang 《Macromolecular theory and simulations》1993,2(2):263-268
A statistical thermodynamics theory of polydisperse polymer mixtures with strong interaction between dissimilar components based on a lattice fluid model is formulated. Expressions for the free energy, equation of state, phase stability and spinodal for a polydisperse, binary polymer mixture with strong interaction are derived. 相似文献
949.
950.