Microfluidic flows of wormlike micellar solutions

The widespread use of wormlike micellar solutions is commonly found in household items such as cosmetic products, industrial fluids used in enhanced oil recovery and as drag reducing agents, and in biological applications such as drug delivery and biosensors. Despite their extensive use, there are still many details about the microscopic micellar structure and the mechanisms by which wormlike micelles form under flow that are not clearly understood. Microfluidic devices provide a versatile platform to study wormlike micellar solutions under various flow conditions and confined geometries. A review of recent investigations using microfluidics to study the flow of wormlike micelles is presented here with an emphasis on three different flow types: shear, elongation, and complex flow fields. In particular, we focus on the use of shear flows to study shear banding, elastic instabilities of wormlike micellar solutions in extensional flow (including stagnation and contraction flow field), and the use of contraction geometries to measure the elongational viscosity of wormlike micellar solutions. Finally, we showcase the use of complex flow fields in microfluidics to generate a stable and nanoporous flow-induced structured phase (FISP) from wormlike micellar solutions. This review shows that the influence of spatial confinement and moderate hydrodynamic forces present in the microfluidic device can give rise to a host of possibilities of microstructural rearrangements and interesting flow phenomena.     

Performance implications of chemical mobilization after microchannel IEF

Chemical mobilization following IEF enables single‐point detection of an ideally stationary equilibrium electrophoresis mode. Despite prior studies exploring optimization of chemical mobilization conditions and recent insight from numerical simulations, understanding of both chemical mobilization mechanisms and the implications of mobilization on IEF analytical performance remains limited. In this study, we utilize full‐field imaging of microchannel IEF to assess the performance of a range of canonical chemical mobilization schemes. We empirically demonstrate and characterize key areas where limited understanding of performance implications exists, including: the effects of mobilization solution pH and ion concentration, differences between ionic and zwitterionic mobilization, and diffusion as a source of zone broadening. We utilize Simul5 simulations to gain insight into the sources of the measured performance differences. Measurements of the location, linearity, and slope of the IEF pH gradient (via fluorescent pH markers imaged before and during mobilization) as well as mobilization‐associated broadening of focused analytes were performed to quantify performance and determine the dominant sources of variability. Our results suggest that nonuniform broadening of the pH gradient and changes in the pH gradient linearity stem from conductivity nonuniformities in the separation channel and not diffusion‐associated band broadening during mobilization.     

Modulating the Binding of Polycyclic Aromatic Hydrocarbons Inside a Hexacationic Cage by Anion–π Interactions

We report the template‐directed synthesis of BlueCage⁶⁺, a macrobicyclic cyclophane composed of six pyridinium rings fused with two central triazines and bridged by three paraxylylene units. These moieties endow the cage with a remarkably electron‐poor cavity, which makes it a powerful receptor for polycyclic aromatic hydrocarbons (PAHs). Upon forming a 1:1 complex with pyrene in acetonitrile, however, BlueCage?6 PF₆ exhibits a lower association constant K_a than its progenitor ExCage?6 PF₆. A close inspection reveals that the six PF₆^? counterions of BlueCage⁶⁺ occupy the cavity in a fleeting manner as a consequence of anion–π interactions and, as a result, compete with the PAH guests. This conclusion is supported by a one order of magnitude increase in the K_a value for pyrene in BlueCage⁶⁺ when the PF₆^? counterions are replaced by much bulkier anions. The presence of anion–π interactions is supported by X‐ray crystallography, and confirms the presence of a PF₆^? counterion inside its cavity.     

A Comparison of Two Methods of Formant Frequency Estimation for High-Pitched Voices

This study sought to compare formant frequencies estimated from natural phonation to those estimated using two methods of artificial laryngeal stimulation: (1) stimulation of the vocal tract using an artificial larynx placed on the neck and (2) stimulation of the vocal tract using an artificial larynx with an attached tube placed in the oral cavity. Twenty males between the ages of 18 and 45 performed the following three tasks on the vowels /a/ and /i/: (1) 4 seconds of sustained vowel, (2) 2 seconds of sustained vowel followed by 2 seconds of artificial phonation via a neck placement, and (3) 4 seconds of sustained vowel, the last two of which were accompanied by artificial phonation via an oral placement. Frequencies for formants 1-4 were measured for each task at second 1 and second 3 using linear predictive coding. These measures were compared across second 1 and second 3, as well as across all three tasks. Neither of the methods of artificial laryngeal stimulation tested in this study yielded formant frequency estimates that consistently agreed with those obtained from natural phonation for both vowels and all formants. However, when estimating mean formant frequency data for samples of large N, each of the methods agreed with mean estimations obtained from natural phonation for specific vowels and formants. The greatest agreement was found for a neck placement of the artificial larynx on the vowel /a/.     

Botulinum Toxin Type B for Treatment of Spasmodic Dysphonia: A Case Report

Although treatment with botulinum toxin type A (BTXA) has become the standard of care for most patients with laryngeal dystonia, its use is limited by the development of resistance to the toxin in some patients. Botulinum toxin type B (BTXB) has been found to be safe and effective in the treatment of cervical dystonia, but it has not been used previously to treat spasmodic dysphonia. Our experience with BTXB in a patient who developed resistance to BTXA suggests that BTXB may be safe and effective for the treatment of laryngeal dystonia, as well.     

Development of anodes for direct electrocatalytic oxidation of methane in solid oxide fuel cells

Gold-doped nickel/zirconia and nickel/ceria cermet anodes incorporating different levels of gold have been prepared and studied as potential anodes for the direct electrocatalytic oxidation of methane in solid oxide fuel cells. The methane conversion activity and selectivity towards synthesis gas products of these anodes have been determined over a range of SOFC operating temperatures and methane/oxidant ratios, and compared with the corresponding undoped nickel cermet. The amount of carbon deposition has been determined using post-reaction temperature programmed oxidation. The influence of gold loading on the methane conversion activity, product selectivity and amount of carbon deposition has been determined. The addition of small amounts of gold to nickel cermets results in a dramatically increased tolerance to carbon deposition and a reduction in the activity of the anode and the selectivity towards partial oxidation compared to the corresponding undoped nickel cermet. Paper presented at the 9th EuroConference on Ionics, Ixia, Rhodes, Greece, Sept. 15–21, 2002.     

Properties of the Reflected Ornstein–Uhlenbeck Process

Consider an Ornstein–Uhlenbeck process with reflection at the origin. Such a process arises as an approximating process both for queueing systems with reneging or state-dependent balking and for multi-server loss models. Consequently, it becomes important to understand its basic properties. In this paper, we show that both the steady-state and transient behavior of the reflected Ornstein–Uhlenbeck process is reasonably tractable. Specifically, we (1) provide an approximation for its transient moments, (2) compute a perturbation expansion for its transition density, (3) give an approximation for the distribution of level crossing times, and (4) establish the growth rate of the maximum process.     

Model studies towards liquid crystalline dendrimers with mesogenic repeat units throughout the structure

Model studies towards liquid crystal dendrimers in which the mesogenic units are based on alkoxyalkylbiphenyls and repeat through the structure are described; the parent monomers show smectic mesophases demonstrating the suitability of the motifs.