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91.
Abd El-Galil E. Amr Salwa F. Mohamed Naglaa A. Abdel-Hafez Mohamed M. Abdalla 《Monatshefte für Chemie / Chemical Monthly》2008,139(12):1491-1498
A series of oxadiazole pyridine derivatives were synthesized by using 2-chloro-6-hydrazinoisonicotinic acid hydrazide as starting material. Treatment of the hydrazide with carbon disulfide to afford the oxadiazole derivative, which was treated with 5-methyl-2-furancarbaldehyde, formic acid, acetic acid/acetic anhydride, or phthalic anhydride to yield the corresponding pyridinodiazoles and on imide. Condensation of the hydrazide with p-fluorobenzaldehyde in ethanol or acetic acid in the presence of sodium acetate afforded hydrazone and oxadiazole derivatives, which were acetylated and cyclized with acetic anhydride to N-acetyloxadiazole derivatives. The hydrazone was treated with acetic acid in the presence of sodium acetate, or bromine water/sodium acetate to give on oxadiazole, while it was cyclized with chloroacetyl chloride in the presence of TEA to oxoazetidinaminoisonicotinamide. Finally, condensation of the hydrazide with acid anhydrides in refluxing glacial acetic acid afforded the corresponding bisimide derivatives. The pharmacological screening showed that many of these obtained compounds have good antianexiety activity comparable to diazepam® as positive control. 相似文献
92.
An Efficient One‐pot Synthesis of Novel Spiro Cyclic 2‐Oxindole Derivatives of Pyrimido[4,5‐b]Quinoline,Pyrido[2,3‐d:6,5‐d′]Dipyrimidine and Indeno[2′,1′:5,6]Pyrido [2,3‐d]Pyrimidine in Water
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Amr Mohamed Abdelmoniem Huwaida M. E. Hassaneen Ismail Abdelshafy Abdelhamid 《Journal of heterocyclic chemistry》2016,53(6):2084-2090
A novel and facile one‐pot synthesis of spiro cyclic 2‐oxindole derivatives of pyrimido[4,5‐b]quinoline‐4,6‐dione, pyrido[2,3‐d:6,5‐d′]dipyrimidine‐2,4,6‐trione, and indeno[2′,1′:5,6]pyrido [2,3‐d]pyrimidine employing 6‐aminothiouracil (or 6‐aminouracil), isatin, and cyclic 1,3‐diketone (e.g. 1,3‐indanedione, dimedone, or barbituric acid) has been developed. 相似文献
93.
Raimund Marx Nikolas Pomplun Wolfgang Bermel Heinz Zeiger Frank Engelke Amr F. Fahmy Steffen J. Glaser 《Magnetic resonance in chemistry : MRC》2015,53(6):442-447
The realization of an all‐heteronuclear 5‐qubit nuclear magnetic resonance quantum computer is reported, from the design and synthesis of a suitable molecule through the engineering of a prototype 6‐channel probe head. Full control over the quantum computer is shown by a benchmark experiment. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
94.
Mohamed Amr Fahim Asmaa M. Ibrahim Samah Abd Elhamead Ibrahim Medhat A. 《Structural chemistry》2021,32(6):2115-2138
Structural Chemistry - In this investigation, we elucidate the potential interaction of volatile organic solvents such as acetone and ethanol with adrenaline hormone through hydrogen bonding. There... 相似文献
95.
Nonlinear Dynamics - This paper presents an analytical framework to investigate the dynamical behavior of a recent chaotic jerk model with multiple attractors. The methods of analytical analysis... 相似文献
96.
Yousri D. A. AbdelAty Amr M. Said Lobna A. Elwakil A. S. Maundy Brent Radwan Ahmed G. 《Nonlinear dynamics》2019,95(3):2491-2542
Nonlinear Dynamics - Fractional-order chaotic systems (FOCS) parameter identification is an essential issue in chaos control and synchronization process. In this paper, different recent... 相似文献
97.
Kitova EN El-Hawiet A Schnier PD Klassen JS 《Journal of the American Society for Mass Spectrometry》2012,23(3):431-441
The association-dissociation of noncovalent interactions between protein and ligands, such as other proteins, carbohydrates,
lipids, DNA, or small molecules, are critical events in many biological processes. The discovery and characterization of these
interactions is essential to a complete understanding of biochemical reactions and pathways and to the design of novel therapeutic
agents that may be used to treat a variety of diseases and infections. Over the last 20 y, electrospray ionization mass spectrometry
(ESI-MS) has emerged as a versatile tool for the identification and quantification of protein–ligand interactions in vitro.
Here, we describe the implementation of the direct ESI-MS assay for the determination of protein–ligand binding stoichiometry
and affinity. Additionally, we outline common sources of error encountered with these measurements and various strategies
to overcome them. Finally, we comment on some of the outstanding challenges associated with the implementation of the assay
and highlight new areas where direct ESI-MS measurements are expected to make significant contributions in the future. 相似文献
98.
Omar M. Ali Abd El-Galil E. Amr Elsayed E. Mostafa 《Research on Chemical Intermediates》2014,40(4):1545-1556
A series of tetrazolomethylbenzo[d][1,2,3]triazole derivatives (2–14) have been synthesized and evaluated as antimicrobial agents from 1H-benzo[d][1,2,3]triazole (1) as starting material. The reaction of benzotriazole 1 with chloroacetonitrile afforded 2-(1H-benzo[d][1,2,3]-triazol-1-yl)acetonitrile 2, which was reacted with sodium azide to give tetrazole derivative 3. Esterification of benzotriazole 1 with ethyl bromoacetate in the presence of anhydrous potassium carbonate afforded ester 4, which was treated with hydrazine hydrate to afford the corresponding hydrazide 5. Reaction of 3 with 2,3,4,6-tetra-O-acetyl-α-d-glucopyranosyl bromide afforded the nitro-glycoside derivative 6, which was deacetylated using methanolic ammonia to deprotected nitroglycoside 7. The hydrazide 5 was reacted with 4,5,6,7-tetrachlorophthalic anhydride or 1,2,4,5-benzenetetracarboxylic dianhydride in refluxing glacial acetic acid to give the corresponding imides 8 and 9, respectively. Also, the hydrazide 5 was reacted with carbon disulphide in ethanol to give potassium salt 10, which was reacted with hydrazine hydrate to afford aminotriazole derivative 11. The latter compound was reacted with carbon disulphide to afford thiadiazole derivative 12, which was treated with 2,3,4,6-tetra-O-acetyl-α-d-glucopyranosyl bromide to give the thioglycoside derivative 13. Deacetylation of the thioglycoside 13 using methanolic ammonia solution at room temperature afforded the deprotected thioglycoside 14. The antimicrobial screening of some synthesized compounds showed that many of these compounds have good antimicrobial activities comparable to streptomycin and fusidic acid as reference drugs. 相似文献
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100.
H. S. Abd-Elghaffar M. A. El-Hashash S. F. Mohamed A. A. Ibrahim A. E. Amr M. A. Al-Omar E. S. Nossier 《Russian Journal of General Chemistry》2020,90(4):686-696
A new series of fused 1,3-indandione derivatives has been synthesized and evaluated for anti-proliferative activity. 2-Alkene-1,3-indandione derivatives have been used as the precursors of a number of tricyclic compounds. The latter have been tested for anti-proliferative activity. 相似文献