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21.
María Constanza Luciardi María Amparo Blzquez María Rosa Alberto Elena Cartagena Mario Eduardo Arena 《Molecules (Basel, Switzerland)》2021,26(10)
The chemical composition of three Citrus limon oils: lemon essential oil (LEO), lemon terpenes (LT) and lemon essence (LE), and their influence in the virulence factors production and motility (swarming and swimming) of two Pseudomonas aeruginosa strains (ATCC 27853 and a multidrug-resistant HT5) were investigated. The main compound, limonene, was also tested in biological assays. Eighty-four compounds, accounting for a relative peak area of 99.23%, 98.58% and 99.64%, were identified by GC/MS. Limonene (59–60%), γ-terpinene (10–11%) and β-pinene (7–15%) were the main compounds. All lemon oils inhibited specific biofilm production and bacterial metabolic activities into biofilm in a dose-dependent manner (20–65%, in the range of 0.1–4 mg mL−1) of both strains. Besides, all samples inhibited about 50% of the elastase activity at 0.1 mg mL−1. Pyocyanin biosynthesis decreases until 64% (0.1–4 mg mL−1) for both strains. Swarming motility of P. aeruginosa ATCC 27853 was completely inhibited by 2 mg mL−1 of lemon oils. Furthermore, a decrease (29–55%, 0.1–4 mg mL−1) in the synthesis of Quorum sensing (QS) signals was observed. The oils showed higher biological activities than limonene. Hence, their ability to control the biofilm of P. aeruginosa and reduce the production of virulence factors regulated by QS makes lemon oils good candidates to be applied as preservatives in the food processing industry. 相似文献
22.
23.
Synthesis of New Chlorin e6 Trimethyl and Protoporphyrin IX Dimethyl Ester Derivatives and Their Photophysical and Electrochemical Characterizations
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Dr. José C. J. M. D. S. Menezes Prof. M. Amparo F. Faustino Prof. Kleber T. de Oliveira Dr. Marciana P. Uliana Prof. Vitor F. Ferreira Dr. Steffen Hackbarth Prof. Beate Röder Dr. Thiago Teixeira Tasso Dr. Taniyuki Furuyama Prof. Nagao Kobayashi Prof. Artur M. S. Silva Prof. M. Graça P. M. S. Neves Prof. José A. S. Cavaleiro 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(42):13644-13655
In view of increasing demands for efficient photosensitizers for photodynamic therapy (PDT), we herein report the synthesis and photophysical characterizations of new chlorin e6 trimethyl ester and protoporphyrin IX dimethyl ester dyads as free bases and ZnII complexes. The synthesis of these molecules linked at the β‐pyrrolic positions to pyrano[3,2‐c]coumarin, pyrano[3,2‐c]quinolinone, and pyrano[3,2‐c]naphthoquinone moieties was performed by using the domino Knoevenagel hetero Diels–Alder reaction. The α‐methylenechromanes, α‐methylenequinoline, and ortho‐quinone methides were generated in situ from a Knoevenagel reaction of 4‐hydroxycoumarin, 4‐hydroxy‐6‐methylcoumarin, 4‐hydroxy‐N‐methylquinolinone, and 2‐hydroxy‐1,4‐naphthoquinone, respectively, with paraformaldehyde in dioxane. All the dyads as free bases and as ZnII complexes were obtained in high yields. All new compounds were fully characterized by 1D and 2D NMR techniques, UV/Vis spectroscopy, and HRMS. Their photophysical properties were evaluated by measuring the fluorescence quantum yield, the singlet oxygen quantum yield by luminescence detection, and also the triplet lifetimes were correlated by flash photolysis and intersystem crossing (ISC) rates. The fluorescence lifetimes were measured by a time‐correlated single photon count (TCSPC) method, fluorescence decay associated spectra (FDAS), and anisotropy measurements. Magnetic circular dichroism (MCD) and circular dichroism (CD) spectra were recorded for one ZnII complex in order to obtain information, respectively, on the electronic and conformational states, and interpretation of these spectra was enhanced by molecular orbital (MO) calculations. Electrochemical studies of the ZnII complexes were also carried out to gain insights into their behavior for such applications. 相似文献
24.
Stefania Sandoval Nitesh Kumar Dr. A. Sundaresan Prof. C. N. R. Rao Prof. Amparo Fuertes Dr. Gerard Tobias 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(38):11999-12003
Nitrogen‐doped reduced graphene oxide (N‐doped RGO) samples with a high level of doping, up to 13 wt. %, have been prepared by annealing graphene oxide under a flow of pure ammonia. The presence of nitrogen within the structure of RGO induces a remarkable increase in the thermal stability against oxidation by air. The thermal stability is closely related with the temperature of synthesis and the nitrogen content. The combustion reaction of nitrogen in different coordination environments (pyridinic, pyrrolic, and graphitic) is analyzed against a graphene fragment (undoped) from a thermodynamic point of view. In agreement with the experimental observations, the combustion of undoped graphene turns out to be more spontaneous than when nitrogen atoms are present. 相似文献
25.
B. Cantó C. Coll E. Sánchez S. C. Cardona J. Navarro-Laboulais 《Journal of mathematical chemistry》2014,52(4):1023-1035
The dynamics of the composition of chemical species in reacting systems can be characterized by a set of autonomous differential equations derived from mass conservation principles and some elementary hypothesis related to chemical reactivity. These sets of ordinary differential equations (ODEs) are basically non-linear, their complexity grows as much increases the number of substances present in the reacting media and can be characterized by a set of phenomenological constants (kinetic rate constants) which contains all the relevant information about the physical system. The determination of these kinetic constants is critical for the design or control of chemical systems from a technological point of view but the non-linear nature of the ODEs implies that there are hidden correlations between the parameters which maybe can be revealed with a identifiability analysis. 相似文献
26.
Integral representations are considered of solutions of the Airy differential equation w
–zw=0 for computing Airy functions for complex values of z. In a first method contour integral representations of the Airy functions are written as non-oscillating integrals for obtaining stable representations, which are evaluated by the trapezoidal rule. In a second method an integral representation is evaluated by using generalized Gauss–Laguerre quadrature; this approach provides a fast method for computing Airy functions to a predetermined accuracy. Comparisons are made with well-known algorithms of Amos, designed for computing Bessel functions of complex argument. Several discrepancies with Amos' code are detected, and it is pointed out for which regions of the complex plane Amos' code is less accurate than the quadrature algorithms. Hints are given in order to build reliable software for complex Airy functions. 相似文献
27.
López-Martín J Anam EM Boira H Sanz MJ Blázquez MA 《Chemical & pharmaceutical bulletin》2002,50(12):1613-1615
Dennettine, a new 2,6-dimethoxychromone and three known phenanthrene alkaloids (uvariopsine, stephenanthrine and argentinine) in addition to the phenolic and known compound vanillin were isolated from the roots of Dennettia tripetala. Their structures were determined by physical and spectroscopical one dimensional (1D) and 2D-NMR analysis, including heteronuclear multiple bond correlation and nuclear Overhauser enhancement spectroscopy. 相似文献
28.
Delgado J Espinós A Jiménez MC Miranda MA 《Chemical communications (Cambridge, England)》2002,(22):2636-2637
Formation of an o-quinone methide via C-C fragmentation of a zwitterion formed by intramolecular excited state proton transfer from an o-allylphenol derivative is reported for the first time. 相似文献
29.
Barluenga J Aznar F Gutiérrez I García-Granda S Llorca-Baragaño MA 《Organic letters》2002,4(24):4273-4276
[reaction: see text] The first cyclopropanation reaction of olefins with Fischer dialkylaminocarbene complexes is presented. The reaction yields 1-aminocyclopropanecarboxylic acid derivatives in a single step, usually with high diastereoselectivity. An approach to the asymmetric version of this reaction is also presented. The synthetic utility of the procedure is exemplified by the synthesis of both cycles of metanoproline in a single step. In addition, the synthesis of the first Fischer carbene containing a halocarbonyl group is reported. 相似文献
30.
We report experimental measurements of the phase behavior of mixtures of thin (charged semiflexible fd virus) and thick (fd-PEG, fd virus covalently coated with polyethylene glycol) rods with diameter ratio varying from 3.7 to 1.1. The phase diagrams of the rod mixtures reveal isotropic-nematic, isotropic-nematic-nematic, and nematic-nematic coexisting phases with increasing concentration. In stark contrast to predictions from earlier theoretical work, we observe a nematic-nematic coexistence region bound by a lower critical point. Moreover, we show that a rescaled Onsager-type theory for binary hard-rod mixtures qualitatively describes the observed phase behavior. 相似文献