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991.
Ab initio and density functional theoretical studies on hydrogen-bonded complexes of azabenzenes with water, acetamide, and thioacetamide have been carried out to explore the controversy involved in the relative order of their stability in a systematic way. The interaction energies of these complexes have been analyzed using the Morokuma energy decomposition method, and the nature of the various hydrogen bonds formed has been investigated through topological aspects using Bader's atom in a molecule (AIM) theory. Morokuma energy decomposition analysis reveals that the major contributions to the energetics are from the polarization (PL) and charge transfer (CT) energies. From the calculated topological results, excellent linear correlation is shown to exist between the hydrogen-bond length, electron density [rho(r)], and its Laplacian [nabla(2)rho(r)] at the bond critical points for all the complexes considered. 相似文献
992.
Protein adsorption on the mesoporous molecular sieve silicate SBA-15: effects of pH and pore size 总被引:1,自引:0,他引:1
A mesoporous molecular sieve silicate, SBA-15, with three pore sizes (38.1 A, 77.3 A, and 240 A) has been synthesized using a non-ionic, tri-block copolymer as a template in a sol-gel method. The effects of synthesis conditions on the pore size and pore-size distribution of this adsorbent have been described. The adsorption of proteins on these crystalline, ordered, materials has been studied. The kinetics of adsorption and equilibrium capacity have been probed with three proteins of different dimensions. The effects of electrostatic interactions and protein size are illustrated. It has been shown that SBA-15 materials can be tailored to show size selectivity for proteins, and very high capacities (450 mg/g) can be obtained. Furthermore, the rates of adsorption are shown to be dependent on the pore size, protein structure and solution pH. 相似文献
993.
Chakraborty TK Ghosh S Jayaprakash S Sarma JA Ravikanth V Diwan PV Nagaraj R Kunwar AC Sharma JA 《The Journal of organic chemistry》2000,65(20):6441-6457
Furanoid sugar amino acids (1) were synthesized and used as dipeptide isosteres to induce interesting turn structures in small linear peptides. They belong to a new variety of designed hybrid structures that carry both amino and carboxyl groups on rigid furanose sugar rings. Four such molecules, 6-amino-2,5-anhydro-6-deoxy-D-gluconic acid (3, Gaa) and its mannonic (4, Maa), idonic (5, Iaa), and a 3,4-dideoxyidonic (6, ddIaa) congeners were synthesized. The synthesis followed a novel reaction path in which an intramolecular 5-exo S(N)2 opening of the hexose-derived terminal aziridine ring in 2 by the gamma-benzyloxy oxygen with concomitant debenzylation occurred during pyridinium dichromate oxidation of the primary delta-hydroxyl group to carboxyl function, leading to the formation of furanoid sugar amino acid frameworks in a single step. Incorporation of these furanoid sugar amino acids into Leu-enkephalin replacing its Gly-Gly portion gave analogues 8-11. Detailed structural analysis of these molecules by circular dichroism (CD) and various NMR techniques in combination with constrained molecular dynamics (MD) simulations revealed that two of these analogues, 8a and 10a, have folded conformations composed of an unusual nine-membered pseudo beta-turn-like structure with a strong intramolecular H-bond between LeuNH --> sugarC3-OH. This, in turn, brings the two aromatic rings of Tyr and Phe in close proximity, a prerequisite for biological activities of opioid peptides. The analgesic activities of 8a,b determined by mouse hot-plate and tail-clip methods were similar to that of Leu-enkephalin methyl ester. The syn disposition of the beta-hydroxycarboxyl motif on the sugar rings appears to be the driving force to nucleate the observed turn structures in some of these molecules (8 and 10). Repetition of the motif on both sides of a furanose ring resulted in a novel molecular design of sugar diacid, 2,5-anhydro-D-idaric acid (7, Idac). Bidirectional elongation of the diacid moieties of 7 with identical peptide strands led to the formation of a C2-symmetric reverse-turn mimetic 12 which displayed a very ordered structure consisting of identical intramolecular H-bonds at two ends between LeuNH --> sugar-OH, the same as in 8 and 10. 相似文献
994.
Grant J. Sherborne Avetik G. Gevondian Ignacio Funes‐Ardoiz Amit Dahiya Christoph Fricke Franziska Schoenebeck 《Angewandte Chemie (International ed. in English)》2020,59(36):15543-15548
Selective C –C couplings are powerful strategies for the rapid and programmable construction of bi‐ or multiaryls. To this end, the next frontier of synthetic modularity will likely arise from harnessing the coupling space that is orthogonal to the powerful Pd‐catalyzed coupling regime. This report details the realization of this concept and presents the fully selective arylation of aryl germanes (which are inert under Pd0/PdII catalysis) in the presence of the valuable functionalities C?BPin, C?SiMe3, C?I, C?Br, C?Cl, which in turn offer versatile opportunities for diversification. The protocol makes use of visible light activation combined with gold catalysis, which facilitates the selective coupling of C?Ge with aryl diazonium salts. Contrary to previous light‐/gold‐catalyzed couplings of Ar–N2+, which were specialized in Ar–N2+ scope, we present conditions to efficiently couple electron‐rich, electron‐poor, heterocyclic and sterically hindered aryl diazonium salts. Our computational data suggest that while electron‐poor Ar–N2+ salts are readily activated by gold under blue‐light irradiation, there is a competing dissociative deactivation pathway for excited electron‐rich Ar–N2+, which requires an alternative photo‐redox approach to enable productive couplings. 相似文献
995.
The 3-aminocarbazoles 1a-e were condensed with phenyl and benzyl isothiocyanates on montmorillonite K10 clay or TLC-grade silica gel at room temperature to furnish efficiently the N-phenyl and N-benzylthioureidocarbazoles, 2a-e and 2f, respectively, within minutes. When adsorbed on montmorillonite K10 clay impregnated with para-toluene sulfonic acid (1:1, w/w) and heated at 60-70 °C, 2a-e and 2f furnished the 2-anilino and 2-benzylaminothiazolo[4,5-c]carbazoles, 3a-e and 3f, respectively, regioselectively in high yields. The cyclisation was also effective for the N-methylthioureidocarbazoles 2g-i. 相似文献
996.
S. Bandyopadhyay D. Chattopadhyay S. K. Ghosh B. Chakrabarti 《Photochemistry and photobiology》1984,39(6):765-772
Abstract— Fluorometric studies of cataractous and non-cataractous human lenses were carried out to study the emission characteristics and the distribution and solubility of lenticular pigments. Most of the detected fluorophores were well distributed over the cortical and nuclear portion of the lens. The decrease in solubility of proteins with aging and cataract formation is concomitant with increasing photolysis of tryptophan. However, this is likely a phenomenon independent of the photochemical transformations of the lens proteins. The number of emitting species in the diseased lenses are higher than in the normal mature lenses. A species emitting around 375 or 388 nm is of particular interest (λcx , 330 nm) in that the emission characteristics of this fluorophore resemble kynurenic acid which has a high photosensitizing efficiency. The concentration of fluorescent pigments in the lenses of Indian origin is significantly high. The intense pigmentation could be attributed largely to the formation of photoproducts in the absence of normal endogenous antioxidant accumulation that is dependent on nutrition standard. If, indeed, any of these fluorescent pigments, because of their photosensitizing ability, are responsible for lenticular opacity, it is not the abundance of sunlight alone but also malnutrition that could account for the high incidence of cataract in India. 相似文献
997.
The microwave spectrum of 1,2,4-trifluorobenzene has been observed in the range 12.5–18.0 GHz and 21.5–25.3 GHz at dry-ice temperature and assigned up to angular momentum state J = 39. The ground state rotational constants and the five quartic centrifugal distortion constants thus obtained are (in MHz): Ã = 3084.0037 ± 0.0108, B? = 1278.3614 ± 0.0062, C? = 903.6989 ± 0.0108, dj = ( ?4.599 ± 0.621) · 10?4, djk = (5.9757 ± 1.1586) · 10?3, dk = (11.4923 ± 2.0886) · 10?3, dwj = (4.0 ± 1.0) · 10?7, dwk=(?5.8± 1.1) · 10?6.The small value of Δ = 0.029 (amu Å2) shows that the molecule is planar and an r0 - structure using a regular hexagonal benzene ring with the bond lengths C-C = 1.397 Å, C-H = 1.084 Å and C-F = 1.312 Å, reproduces the rotational constants. 相似文献
998.
Background
Interphotoreceptor retinoid-binding protein's (IRBP) remarkable module structure may be critical to its role in mediating the transport of all-trans and 11-cis retinol, and 11-cis retinal between rods, cones, RPE and Müller cells during the visual cycle. We isolated cDNAs for Xenopus IRBP, and expressed and purified its individual modules, module combinations, and the full-length polypeptide. Binding of all-trans retinol, 11-cis retinal and 9-(9-anthroyloxy) stearic acid were characterized by fluorescence spectroscopy monitoring ligand-fluorescence enhancement, quenching of endogenous protein fluorescence, and energy transfer. Finally, the X-ray crystal structure of module-2 was used to predict the location of the ligand-binding sites, and compare their structures among modules using homology modeling. 相似文献999.
Debapriya De Amit Das Brojendranath Dey Bidhan Chandra Roy 《European Polymer Journal》2006,42(4):917-927
The present paper describes the mechanical reclaiming of ground rubber tire (GRT) by tetra methyl thiuram disulfide (TMTD), a multi-functional reclaiming agent. The versatility of the proposed agent is that it acts as a reclaiming agent during reclaiming and as a curing agent during revulcanization of the reclaimed sample. Reclaiming of GRT was carried out on an open two roll mixing mill at various time intervals and different concentrations of the reclaiming agent (TMTD). The degree of reclaiming was evaluated by measurement of the gel content, inherent viscosity of sol rubber, Mooney viscosity of the reclaimed rubber, crosslink density, swelling ratio and molecular weight between two crosslink bonds as a function of milling time. Also, the influence of the gel content on crosslink density at various time intervals on the open two roll mixing mill was determined. A unique correlation between gel fraction and crosslink density obtained at various time intervals and concentrations of reclaiming agent indicated that an optimization of the concentration of TMTD and milling time has a positive influence on improving the efficiency of reclaiming. The reclaiming conditions have been optimized in view of the mechanical properties of the revulcanized GRT and the aging resistance properties of the revulcanized reclaim. The influence of the concentration of sulfur on the mechanical properties in the revulcanized reclaim was also studied. Scanning electron microscopy (SEM) studies further indicate the coherency and homogeneity in the revulcanized reclaim rubber when reclamation is carried out by optimum concentration of TMTD after maximum time of reclaiming. 相似文献
1000.
This is a first quantum chemical study of corrolazine complexes. DFT calculations suggest that despite their extremely contracted central cavities, compared with porphyrins, a variety of corrolazine complexes may be expected to exist as stable compounds. The calculations also indicate that corrolazine complexes may be regarded as strongly electron-deficient analogues of corrole complexes. Thus, the calculated valence ionization potentials of P(V) and Cu(III) corrolazine derivatives are dramatically higher than those of analogous corrole derivatives. In addition, DFT calculations on Fe(IV) and Mn(IV) corrole and corrolazine derivatives suggest that compared with the often noninnocent corrole ligands, corrolazines are electronically more innocent and stabilize "purer" high-valent states of transition metal ions. 相似文献