Economic Electrochemical Sensors for the Determination of Eszopiclone in Pharmaceutical Formulation with Greenness Profile Assessment

Electrochemical-ion-selective-sensors offer green, rapid, economic and simple analytical-tool in pharmaceutical industry, control processes, physiological measurements and environmental monitoring. In this study, two sensors were introduced for eszopiclone (EZP) determination in pure-form and in pharmaceutical-dosage-forms using drug-ion-exchanger association complex fabrication technique. Two different ion-exchangers were used and compared, tetrakis (4-chlorophenyl) borate in sensor1 and tetraphenyl borate in sensor 2. Such sensors showed superior performance at pH 3.5 over a wide-range of EZP concentration. The proposed method was also assessed using GAPI and analytical Eco-scale. Low cost, short analysis-time, simplicity and greenness of the proposed sensors allow their use for high-through-put analysis in quality-control laboratories.