A novel series of mixed-ligand complexes of 5,5′-{(1E,1E′)-1,4-phenelynebis(diazene-2,1-diyl)}bis(quinolin-8-ol) (H
2L
1) as a primary ligand and 4-aminoantipyrine(L
2) as a secondary ligand with Mn(II) ion were prepared using two general formulae: [Mn
2(H
2L
1)
2(L
2)
2X
4].4Cl (X = OH
2( 1 ), ONO
2−( 2 ), Cl=nil; OAc( 3 ), Cl = nil) and [Mn
2(H
2L
1)(L
2)
2(O
2SO
2)
2]( 4 ). Free ligands and their complexes were characterized. Electronic absorption spectra of the mixed-ligand complexes indicate a distorted octahedral geometry around the central metal ion, and the anions X
− are in the axial positions for all compounds. The ligands behave in a neutral bidentate manner, through nitrogen atoms and oxygen atoms of the carbonyl group (L
2), whereas H
2L
1 coordinated through nitrogen and OH groups as a neutral bidentate ligand. All complexes do not contain coordinated water molecules, but complex ( 1 ) contains four water molecules. The water molecules are removed in a single step. The complexes exhibited magnetic susceptibility corresponding to five unpaired electrons. The antimicrobial activity of the Mn(II) mixed-ligand complexes ( 1–4 ) against two gram-positive bacteria, three local gram-negative bacteria, and three fungi species was tested. Mn(II) mixed-ligand complex ( 2 ) exhibited significant antibacterial activity against
Bacillus cereus,
Staphylococcus aureus,
Escherichia coli,
Klebsiella pneumoniae, and
Pseudomonas sp. Mixed-ligand complex ( 2 ) exhibited a high potential cytotoxicity against the growth of human lung cancer cells.
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