Thermal Decomposition and Melting of A New Carboxyindole Derivative

GV150526A is a novel 2-carboxyindole derivative, recently synthesized by GlaxoWellcome, which is used in treatment or prevention of CNS disorders resulting from neurotoxic damage. It has been prepared in three forms, F1, F2 and F3, having significantly different hydration/dehydration behavior and/or diffraction patterns. Here, we extend the thermal analysis of these polymorphs above 200°C, where all forms are fully dehydrated and the main thermal phenomena are decomposition and melting. Simultaneous TG/DSC measurements have been repeated in wet and dry nitrogen atmospheres over a wide range of heating rates. Form F3 displays a qualitatively different behavior relative to F1 and F2. This fact is interpreted as an evidence of a mechanism of decomposition which sets F3 apart from F1 andF2. The thermal data are summarized by simple heuristic equations and few ‘apparent’enthalpies. This revised version was published online in August 2006 with corrections to the Cover Date.     

Chemistry between magnesium and multiple molecules in tris(8-hydroxyquinoline) aluminum films

Metal organic contacts are at the basis of devices such as organic light emitting diodes (OLEDs). Here, we report a theoretical investigation of the chemical interaction between a Mg atom and an organic film made of tris(8-hydroxyquinoline)aluminum (Alq3) molecules. The latter is modeled either by an isolated molecule or by a bulk crystal. Using first-principles molecular dynamics for structural optimization, we find that an isolated Alq3 molecule and a Mg atom form an ion-pair. However, when the metal atom interacts with molecules in a bulk crystalline environment, we find that an organometallic complex is energetically preferred over the ion-pair. The complex formation is an effect of the environment which makes possible the interaction of the metal atom with several adjacent molecules. Here, our calculated O(1s) and N(1s) core level shifts agree well with recent experimental data on Alq3 films exposed to Mg. Our results resolve the apparent contradiction between experiment and predictions made in previous calculations in which a single Alq3 molecule was used to model a thin film.     

Study of the production of a strange (S = −1) dibaryon in the interactions of K− and π+ on deuterium below 1.5GeV/c

The production of a strange dibaryonic system called H⁺₁ (M = 2.13 GeV/c², S = ?1), has been studied with a missing mass spectrometer, at the CERN Proton Synchrotron, in the reaction K^?d → π^?H⁺₁ and in the line-reversed reaction π⁺d → K⁺H⁺₁ between 0.9 and 1.4 GeV/c.The reactions

$\text{K}{}^{\mathrm{?}}\text{d}\text{→ π}{}^{\mathrm{?}}\text{X}{}^{\mathrm{+}}$

,

$\text{π}{}^{\mathrm{<mtext>d</mtext>}}\text{→}\text{K}{}^{\mathrm{+}}\text{X}{}^{\mathrm{+}}$

,have been studied in a missing mass spectrometer at CERN. The experiment (PS159) is well adapted to search for a signal in the missing mass X⁺ (B = 2, S = ?1) produced in the backward c.m.s. direction, between 2.0 and 2.3 GeV/c². The two reactions have been analysed at three different beam settings: 1.4, 1.06 and 0.92 GeV/c for reaction (1) and 1.4, 1.2 and 1.06 GeV/c for reaction (2).     

Electrophilic Azido Selenenylation of Alkenes. A Simple Synthetic Route to Racemic Taxol Side Chain

Simple alkenes react with PhSeOTf and NaN₃ in MeCN to afford β-phenylseleno azides as the result of a stereospecific trans addition. The regioselectivity of the process is determined by the structure of the alkene.     

Effect of Metal Ions in Organic Synthesis. Part XXX. Synthesis of New 3-Carbonyl- and 3-Carboxy-1-Alkoxycarbonylaminopyrroles from Reaction Catalyzed by Copper(II) Chloride of Alkoxycarbonylazoalkenes with β-Diketones and β-Ketoesters

In the course of our previous investigations, we dealt with the direct synthesis of unknown 1-aminopyrroie derivatives, obtained by reaction of some azoalkenes with B-diketones, 8- ketoesters, or B-ketoamides under copper (II) ionscatalysis. 1-9     

Quantification of drug amorphous fraction by DSC

The processes of production of drugs and dosage forms in the solid state often cause unwanted transformation of portions of the substances into amorphous state, with significant changes of properties such as stability and bio-availability. When this amorphous fraction is of the order of a few percent, it usually goes unnoticed, but it should be accurately determined within a quality control system. In this work, we consider a model drug, perphenazine, where partial amorphisation may be induced by standard mechanical treatments. We show that Differential Scanning Calorimetry (DSC) leads to consistent estimations of the amorphous fractions induced by the treatment. Furthermore, DSC also yields the expected amounts of amorphous perphenazine when analysing known mixtures of perfectly crystalline samples (untreated) and partially amorphous samples (treated). We show that even amorphous fractions of the order of 1% are accurately estimated by our method.     

Stemodane Diterpenes and Diterpenoids: Isolation,Structure Elucidation,Biogenesis, Biosynthesis,Biological Activity,Biotransformations, Metabolites and Derivatives Biological Activity,Rearrangements

The scientific activity carried out over forty-five years on stemodane diterpenes and diterpenoids structure elucidation, biogenesis, biosynthesis, biological activity and biotransformations was reviewed.     

Some properties for quaternionic slice regular functions on domains without real points

The theory of slice regular functions over the quaternions, introduced by Gentili and Struppa in 2007, was born on balls centred in the origin and has been extended to more general domains that intersect the real axis in a work of 2009 in collaboration with Colombo and Sabadini. This hypothesis can be overcome using the theory of stem functions introduced by Ghiloni and Perotti in 2011, in the context of real alternative algebras. In this paper, I will recall the notion and the main properties of stem functions. After that I will introduce the class of slice regular functions induced by stem functions and, in this set, I will extend the identity principle, the maximum and minimum modulus principles and the open mapping theorem. Differences will be shown between the case when the domain does or does not intersect the real axis.