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排序方式: 共有324条查询结果,搜索用时 78 毫秒
61.
62.
Martin AL Hickey JL Ablack AL Lewis JD Luyt LG Gillies ER 《Journal of nanoparticle research》2009,12(5):1599-1608
The imaging of molecular markers associated with disease offers the possibility for earlier detection and improved treatment monitoring. Receptors for gastrin-releasing peptide are overexpressed on prostate cancer cells offering a promising imaging target, and analogs of bombesin, an amphibian tetradecapeptide have been previously demonstrated to target these receptors. Therefore, the pan-bombesin analog [β-Ala11, Phe13, Nle14]bombesin-(7-14) was conjugated through a linker to dye-functionalized superparamagnetic iron oxide nanoparticles for the development of a new potential magnetic resonance imaging probe. The peptide was conjugated via click chemistry, demonstrating a complementary alternative methodology to conventional peptide-nanoparticle conjugation strategies. The peptide-functionalized nanoparticles were then demonstrated to be selectively taken up by PC-3 prostate cancer cells relative to unfunctionalized nanoparticles and this uptake was inhibited by the presence of free peptide, confirming the specificity of the interaction. This study suggests that these nanoparticles have the potential to serve as magnetic resonance imaging probes for the detection of prostate cancer. 相似文献
63.
A. Paul Krapcho Silvia Sparapani Amber Leenstra Joshua D. Seitz 《Tetrahedron letters》2009,50(26):3195-3747
The synthesis and structural assignments of 9-chloro-1,1-phenanthroline-2(1H)-thione and 1,10-dihydro-1,10-phenanthroline-2,9-dithione have been accomplished. The sulfur-bridged bis-1,10-phenanthroline macrocycle was readily prepared by heating the thione or equimolar amounts of the dithione and 2,9-dichloro-1,10-phenanthroline in diphenyl ether. Displacements of 2-chloro- or 2,9-dichloro-1,10-phenanthroline with N,N-dimethylethylenediamine afforded the corresponding amine and diamino analogues. An amino-substituted-2,2′-bis-1,10-phenanthroline has been prepared. 相似文献
64.
Gaspar AB Ksenofontov V Reiman S Gütlich P Thompson AL Goeta AE Muñoz MC Real JA 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(36):9289-9298
The crystal structure of the complex [{Fe(bt)(NCS)(2)}(2)bpym] (1) (bt=2,2'-bithiazoline, bpym=2,2'-bipyrimidine) has been solved at 293, 240, 175 and 30 K. At all four temperatures the crystal remains in the P space group with a=8.7601(17), b=9.450(2), c=12.089(3) A, alpha=72.77(2), beta=79.150(19), gamma=66.392(18) degrees , V=873.1(4) Angstrom(3) (data for 293 K structure). The structure consists of centrosymmetric dinuclear units in which each iron(II) atom is coordinated by two NCS(-) ions in the cis position and two nitrogen atoms of the bridging bpym ligand, with the remaining positions occupied by the peripheral bt ligand. The iron atom is in a severely distorted octahedral FeN(6) environment. The average Fe--N bond length of 2.15(9) Angstrom indicates that compound 1 is in the high-spin state (HS-HS) at 293 K. Crystal structure determinations at 240, 175 and 30 K gave a cell comparable to that seen at 293 K, but reduced in volume. At 30 K, the average Fe--N distance is 1.958(4) Angstrom, showing that the structure is clearly low spin (LS-LS). At 175 K the average Fe--N bond length of 2.052(11) Angstrom suggests that there is an intermediate phase. M?ssbauer investigations of the light-induced excited spin state trapping (LIESST) effect (lambda=514 nm, 25 mW cm(-2)) in 1 (4.2 K, H(ext)=50 kOe) show that the excited spin states correspond to the HS-HS and HS-LS pairs. The dynamics of the relaxation of the photoexcited states studied at 4.2 K and H(ext)=50 kOe demonstrate that HS-HS pairs revert with time to both HS-LS and LS-LS configurations. The HS-LS photoexcited pairs relax with time back to the ground LS-LS configuration. Complex [{Fe(0.15)Zn(0.85)(bt)(NCS)(2)}(2)bpym] (2) exhibits a continuous spin transition centred around 158 K in contrast to the two-step transition observed for 1. The different spin-crossover behaviour observed for 2 is due to the decrease of cooperativity (intermolecular interactions) imposed by the matrix of Zn(II) ions. This clearly demonstrates the role of the intermolecular interactions in the stabilization of the HS-LS intermediate state in 1. 相似文献
65.
Gildner PG Gietter AA Cui D Watson DA 《Journal of the American Chemical Society》2012,134(24):9942-9945
The C-alkylation of nitroalkanes under mild conditions has been a significant challenge in organic synthesis for more than a century. Herein we report a simple Cu(I) catalyst, generated in situ, that is highly effective for C-benzylation of nitroalkanes using abundant benzyl bromides and related heteroaromatic compounds. This process, which we believe proceeds via a thermal redox mechanism, allows access to a variety of complex nitroalkanes under mild reaction conditions and represents the first step toward the development of a general catalytic system for the alkylation of nitroalkanes. 相似文献
66.
We study the three-dimensional forced-dissipated Gross-Pitaevskii equation. We force at relatively low wave numbers, expecting to observe a direct energy cascade and a consequent power-law spectrum of the form k−α. Our numerical results show that the exponent α strongly depends on how the inverse particle cascade is attenuated at ks lower than the forcing wave-number. If the inverse cascade is arrested by a friction at low ks, we observe an exponent which is in good agreement with the weak wave turbulence prediction k−1. For a hypo-viscosity, a k−2 spectrum is observed which we explain using a critical balance argument. In simulations without any low k dissipation, a condensate at k=0 is growing and the system goes through a strongly turbulent transition from a 4-wave to a 3-wave weak turbulence acoustic regime with evidence of k−3/2 Zakharov-Sagdeev spectrum. In this regime, we also observe a spectrum for the incompressible kinetic energy which formally resembles the Kolmogorov k−5/3, but whose correct explanation should be in terms of the Kelvin wave turbulence. The probability density functions for the velocities and the densities are also discussed. 相似文献
67.
CY Tang N Phillips JI Bates AL Thompson MJ Gutmann S Aldridge 《Chemical communications (Cambridge, England)》2012,48(65):8096-8098
The reactions of Me(2)NH·BH(3) with cationic Rh(III) and Ir(III) complexes have been shown to generate the 18-electron aminoborane adduct [Ir(IMes)(2)(H)(2){κ(2)-H(2)BNMe(2))](+) and the remarkable 14-electron aminoboryl complex [Rh(IMes)(2)(H)-{B(H)NMe(2))](+). Neutron diffraction studies have been used for the first time to define H-atom locations in metal complexes of this type formed under catalytic conditions. 相似文献
68.
In this paper, a contribution to the study of the unsteady behavior of a back-facing step flow is reported. The main interest
is devoted to low-frequency motions. A probe for skin friction measurements is employed to acquire time histories from the
step to downstream the reattachment region. Signals are analyzed in the physical space and in the frequency domain. The obtained
results, associated with flow visualization in a companion experiment in water, support a model of cyclic motion of growing
and successive breakdown of the secondary recirculating bubble. The frequency of this quasi-periodic motion is comparable
to the flapping frequency of the whole separated region, reported in the literature.
Received: 14 February 2000/Accepted: 5 September 2000 相似文献
69.
Amber L. Norman 《Tetrahedron letters》2007,48(39):6849-6851
3,5-Disubstituted Δ2-isoxazolines can be prepared from the corresponding β,γ-unsaturated ketones by treatment with hydroxylamine hydrochloride and sodium hydroxide. Evidence indicates that the mechanism of this reaction involves the formation of three intermediates; oximation of the ketone, rearrangement of the alkene, and intramolecular Michael addition of the resulting α,β-unsaturated oxime. 相似文献
70.
[reaction: see text] Addition of organolithium and organomagnesium reagents to N-(tri-n-butylstannylmethyl)phthalimides yields N-(tri-n-butylstannylmethyl) cyclic carbinol amides, which form azomethine ylides upon treatment with HF.pyridine. This novel route to azomethine ylides allows rapid access to highly functionalized pyrrolizidines (1,2,3,9b-tetrahydropyrrolo[2,1-a]isoindol-5-ones). 相似文献