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551.
Juman Mohammed Rasmi Alamil Keshav Raj Paudel Yinghan Chan Dikaia Xenaki Jithendra Panneerselvam Sachin Kumar Singh Monica Gulati Niraj Kumar Jha Deepak Kumar Parteek Prasher Gaurav Gupta Raniya Malik Brian George Oliver Philip Michael Hansbro Kamal Dua Dinesh Kumar Chellappan 《Molecules (Basel, Switzerland)》2022,27(9)
The inflammatory response is a central aspect of the human immune system that acts as a defense mechanism to protect the body against infections and injuries. A dysregulated inflammatory response is a major health concern, as it can disrupt homeostasis and lead to a plethora of chronic inflammatory conditions. These chronic inflammatory diseases are one of the major causes of morbidity and mortality worldwide and the need for them to be managed in the long term has become a crucial task to alleviate symptoms and improve patients’ overall quality of life. Although various synthetic anti-inflammatory agents have been developed to date, these medications are associated with several adverse effects that have led to poor therapeutic outcomes. The hunt for novel alternatives to modulate underlying chronic inflammatory processes has unveiled nature to be a plentiful source. One such example is agarwood, which is a valuable resinous wood from the trees of Aquilaria spp. Agarwood has been widely utilized for medicinal purposes since ancient times due to its ability to relieve pain, asthmatic symptoms, and arrest vomiting. In terms of inflammation, the major constituent of agarwood, agarwood oil, has been shown to possess multiple bioactive compounds that can regulate molecular mechanisms of chronic inflammation, thereby producing a multitude of pharmacological functions for treating various inflammatory disorders. As such, agarwood oil presents great potential to be developed as a novel anti-inflammatory therapeutic to overcome the drawbacks of existing therapies and improve treatment outcomes. In this review, we have summarized the current literature on agarwood and its bioactive components and have highlighted the potential roles of agarwood oil in treating various chronic inflammatory diseases. 相似文献
552.
In this paper, simple relations are proposed for the calculation of Debye temperature θD and melting point Tmof II‐VI and III‐V zincblende semiconductors. Six relations are proposed to calculate the value of θD. Out of these six relations, two are based on plasmon energy data and the others on molecular weight, melting point, ionicity and energy gap. Three simple relations are proposed to calculate the value of Tm. They are based on plasmon energy, molecular weight and ionicity of the semiconductors. The average percentage deviation of all nine equations was calculated. In all cases, except one, it was estimated between 3.34 to 17.42 % for θD and between 2.37 to 10.45 % for Tm. However, in earlier correlations, it was reported between 10.59 to 33.38% for θD and 6.96 to 14.95% for Tm. The lower percentage deviation shows a significant improvement over the empirical relations proposed by earlier workers. The calculated values of θD and Tm from all equations are in good agreement with the available experimental values and the values reported by different workers. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
553.
The hitherto unreported compounds of general structure 3,3′-(alkanediyl)bis-(2,2,2-triaryl-1-oxa-2-stiba-3-azabenzo[d]cyclohex-5-ene) have been synthesized in 48-56% yields by the cyclization of the tetrasodium salt of N,N′-bis(2-hydroxybenzyl)-1,2-diaminoethane(II) or of N,N′-bis(2-hydroxybenzyl)-1,3-diaminopropane(II*) with R3SbBr2 (R = phenyl, p-tolyl, or mesityl). The tetrasodium salts were prepared by the reactions of the corresponding amines with sodium hydride. The amines (II and II*), in turn, were obtained by the sodium borohydride reduction of N,N′-bis(salicylidene)-1,2-diaminoethane and N,N′-bis-(salicylidene)-1,3,-diaminopropane, respectively. The heterocyclic compounds are air stable and moisture insensitive. These compounds have been characterized by elemental analyses, molecular weight determinations, and by IR, far IR, 1H, and 13C NMR spectral studies. © 1996 John Wiley & Sons, Inc. 相似文献