全文获取类型
收费全文 | 384篇 |
免费 | 12篇 |
国内免费 | 3篇 |
专业分类
化学 | 303篇 |
晶体学 | 1篇 |
力学 | 3篇 |
综合类 | 1篇 |
数学 | 21篇 |
物理学 | 70篇 |
出版年
2023年 | 5篇 |
2022年 | 34篇 |
2021年 | 28篇 |
2020年 | 11篇 |
2019年 | 15篇 |
2018年 | 15篇 |
2017年 | 11篇 |
2016年 | 20篇 |
2015年 | 6篇 |
2014年 | 13篇 |
2013年 | 23篇 |
2012年 | 28篇 |
2011年 | 36篇 |
2010年 | 20篇 |
2009年 | 9篇 |
2008年 | 8篇 |
2007年 | 8篇 |
2006年 | 10篇 |
2005年 | 13篇 |
2004年 | 10篇 |
2003年 | 15篇 |
2002年 | 9篇 |
2001年 | 7篇 |
2000年 | 2篇 |
1999年 | 6篇 |
1998年 | 5篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 3篇 |
1991年 | 2篇 |
1990年 | 5篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1956年 | 1篇 |
1955年 | 1篇 |
1903年 | 1篇 |
排序方式: 共有399条查询结果,搜索用时 15 毫秒
211.
Doaa M. Masoud Rasha A. Azzam Fatma Hamdy Amal A.I. Mekawey Hatem A. Abdel‐Aziz 《Journal of heterocyclic chemistry》2019,56(11):3030-3041
A series of novel thiazolyl pyrazolines 7a‐h , 9a‐f , and 11a‐f have been synthesized by the reaction of thioamide derivatives 5a , b with 1‐aryl‐2‐bromoethanones 6a‐d , chloroacetones 8a‐c , and hydrazonoyl chlorides 10a‐c . Additionally, pyrazoles 15a‐c and 20 were prepared starting from enaminone 13 . These newly synthesized compounds were screened for their in vitro antibacterial activity against four bacterial species. Compound 11b showed a moderate activity against Klebsiella pneumoniae. Compounds 7c and 11c revealed a moderate activity against Pseudomonas aeruginosa. In addition, the antifungal activity of the newly synthesized compounds was determined against five fungal strains. Compounds 7e , 7g , and 11e showed a good activity against Aspergillus flavus and Penicillium expansum. 相似文献
212.
Amal K. Das 《Annals of Physics》1973,81(2):394-401
The static linear response of a charged Bose gas in the presence of a magnetic field is studied in a “quasiclassical” model previously proposed for an electron gas. The Bose gas is shown to exhibit different screening behavior. The relevance of the study of a charged Bose gas in relation to understanding the properties of systems like neutron star is discussed. 相似文献
213.
Amal K. Das 《Solid State Communications》1976,18(5):601-604
The Das-Peierls semi-classical model for a theory of electro-migration in metals is extended to a two-band system of electron and hole carriers. It is shown how the “effective charge” on the electro-migrating ion can be obtained from electro-migration experiments in Hall field. An experiment of this type is proposed to determine the charge on an electron-hole drop recently observed in some semi-conductors. 相似文献
214.
Siriwardana AI Kathriarachchi KK Nakamura I Gridnev ID Yamamoto Y 《Journal of the American Chemical Society》2004,126(43):13898-13899
The reaction of methyleneaziridines with o-, m-, and p-acetylpyridines proceeds very smoothly in the presence of a palladium catalyst, affording the biologically very important o-, m-, and p-pyridinylpyrrole derivatives in good to high yields. Not only ortho, meta, and para, but also related substrates, such as acetyl aromatics and hetarenes, can be used as the starting acetyl derivatives to synthesize related compounds to pyridinylpyrrole derivatives. 相似文献
215.
216.
Wasim Ul Bari Najeeb Ur Rehman Ajmal Khan Sobia Ahsan Halim Ye Yuan Mark A.T. Blaskovich Zyta M. Ziora Muhammad Zahoor Sumaira Naz Riaz Ullah Amal Alotaibi Ahmed Al-Harrasi 《Molecules (Basel, Switzerland)》2021,26(7)
In the study, two novel compounds along with two new compounds were isolated from Grewia optiva. The novel compounds have never been reported in any plant source, whereas the new compounds are reported for the first time from the studied plant. The four compounds were characterized as: 5,5,7,7,11,13-hexamethyl-2-(5-methylhexyl)icosahydro-1H-cyclopenta[a]chrysen-9-ol (IX), docosanoic acid (X), methanetriol mano formate (XI) and 2,2’-(1,4-phenylene)bis(3-methylbutanoic acid (XII). The anticholinesterase, antidiabetic, and antioxidant potentials of these compounds were determined using standard protocols. All the isolated compounds exhibited a moderate-to-good degree of activity against acetylcholinesterases (AChE) and butyrylcholinesterase (BChE). However, compound XII was particularly effective with IC50 of 55 μg/mL (against AChE) and 60 μg/mL (against BChE), and this inhibitory activity is supported by in silico docking studies. The same compound was also effective against DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) radicals with IC50 values of 60 and 62 μg/mL, respectively. The compound also significantly inhibited the activities of α-amylase and α-glucosidase in vitro. The IC50 values for inhibition of the two enzymes were recorded as 90 and 92 μg/mL, respectively. The in vitro potentials of compound XII to treat Alzheimer’s disease (in terms of AchE and BChE inhibition), diabetes (in terms of α-amylase and α-glucosidase inhibition), and oxidative stress (in terms of free radical scavenging) suggest further in vivo investigations of the compound for assessing its efficacy, safety profile, and other parameters to proclaim the compound as a potential drug candidate. 相似文献
217.
Magnetic resonance angiographic evaluation of the intracranial vasculature has been predominantly carried out using conventional angiographic techniques such as time of flight and phase contrast sequences. These techniques have good spatial resolution but lack temporal resolution. Newer faster angiographic techniques have been developed to circumvent this limitation. Elliptical centric time-resolved imaging of contrast kinetics (EC-TRICKS) is one such technique which has combined the use of elliptical centric ordering of the k-space with multiphase 3D digital subtraction MR angiogram (MRA) to achieve excellent temporal resolution of the arterial and venous circulations. Its applications have been mainly in the peripheral vasculature. We report the use of this technique in a case of a high-flow, direct carotid-cavernous fistula to demonstrate its potential in intracranial MR angiography. 相似文献
218.
Hala M. Abdelmigid Nahed Ahmed Hussien Amal Ahmed Alyamani Maissa M. Morsi Noha Moslah AlSufyani Hanan Abdulaziz kadi 《Molecules (Basel, Switzerland)》2022,27(4)
This research aims to investigate the synthesis, characterization, and evaluation of the biocompatibility and antibacterial activity of novel zinc oxide (ZnO) nanoparticles (NPs) prepared by Punica granatum peel and coffee ground extracts as the reducing and capping agents. Chemically synthesized ZnONPs were prepared using zinc acetate dihydrate and sodium hydroxide as reducing precursors. ZnONPs were characterized using an ultraviolet-visible spectrophotometer (UV-VIS), X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), and Fourier transform infrared (FTIR) spectroscopy. Peaks of UV spectra were 300 nm for ZnONPs_PPE, 320 nm (ZnONPs_CE), 290 nm, and 440 nm (ZnONP_Chem), thereby confirming ZnONPs formation. The X-ray diffractograms revealed their hexagonal structure. TEM micrographs of the biosynthesized ZnONPs revealed their hexagonal pattern and nanorod shape for ZnONPs_Chem with particle sizes of 118.6 nm, 115.7 nm, and 111.2 nm, respectively. The FTIR analysis demonstrated the presence of proteins, carboxyl, and hydroxyl groups on ZnONPs surfaces that act as reducing and stabilizing agents. ZnONP_Chem shows the antibacterial effect on Staphylococcus aureus, Enterobacter aerogenes, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Punica peel and coffee ground extracts are effective reducing agents for green ZnONPs synthesis with a lower cytotoxic effect on Vero cells than ZnONPs_Chem with IC50 = 111, 103, and 93 μg/mL, respectively. 相似文献
219.
Helminth infections continue to be a neglected global threat in tropical regions, and there have been growing cases of anthelmintic resistance reported towards the existing anthelmintic drugs. Thus, the search for a novel anthelmintic agent has been increasing, especially those derived from plants. Leucaena leucocephala (LL) is a leguminous plant that is known to have several pharmacological activities, including anthelmintic activity. It is widely known to contain a toxic compound called mimosine, which we believed could be a potential lead candidate that could exert a potent anthelmintic effect. Hence, this study aimed to validate the presence of mimosine in LL extract and to investigate the anthelmintic effect of LL extract and mimosine on head thrashing, egg-laying, and pharyngeal pumping activities using the animal model Caenorhabditis elegans (C. elegans). Mimosine content in LL extract was confirmed through an HPLC analysis of spiking LL extract with different mimosine concentrations, whereby an increasing trend in peak heights was observed at a retention time of 0.9 min. LL extract and mimosine caused a significant dose-dependent increase in the percentage of worm mortality, which produced LC50s of 73 mg/mL and 6.39 mg/mL, respectively. Exposure of C. elegans to different concentrations of LL extract and mimosine significantly decreased the head thrashing, egg-laying, and mean pump amplitude of pharyngeal pumping activity. We speculated that these behavioral changes are due to the inhibitory effect of LL extract and mimosine on an L-type calcium channel called EGL-19. Our findings provide evidential support for the potential of LL extract and its active compound, mimosine, as novel anthelmintic candidates. However, the underlying mechanism of the anthelmintic action has yet to be elucidated. 相似文献
220.
5-(Alkylamino)-6-aryl/alkylpyrazine-2,3-dicarbonitriles were successfully synthesized in good to moderate yields by reacting alkyl isocyanides with aryl/alkyl carbonyl chlorides, followed by the addition of diaminomaleonitrile. The synthesized pyrazines were fully characterized in this investigation, and X-ray crystal structure analysis was performed on some derivatives. The antibacterial and antifungal activities of the newly synthesized pyrazine-2,3-dicarbonitriles were assessed in addition to their UV and fluorescence results. All the compounds showed similar UV–Vis spectral features with absorption peaks (λmax) around 267, 303, and 373 nm. 相似文献