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11.
Ingrid Lajdova Livia Ovsonkova Viera Spustova Adrian Oksa Dusan Chorvat Anton Mateasik Alzbeta Marcek Chorvatova 《Molecules (Basel, Switzerland)》2021,26(22)
The interaction of the fluorescent probe 22-NBD-cholesterol with membranes of human peripheral blood mononuclear cells (PBMC) was tested by time- and spectrally resolved fluorescence imaging to monitor the disturbance of lipid metabolism in chronic kidney disease (CKD) and its treatment with statins. Blood samples from healthy volunteers (HV) and CKD patients, either treated or untreated with statins, were compared. Spectral imaging was done using confocal microscopy at 16 spectral channels in response to 458 nm excitation. Time-resolved imaging was achieved by time-correlated single photon counting (TCSPC) following excitation at 475 nm. The fluorescence of 22-NBD-cholesterol was mostly integrated into plasmatic membrane and/or intracellular membrane but was missing from the nuclear region. The presence of two distinct spectral forms of 22-NBD-cholesterol was uncovered, with significant variations between studied groups. In addition, two fluorescence lifetime components were unmasked, changing in CKD patients treated with statins. The gathered results indicate that 22-NBD-cholesterol may serve as a tool to study changes in the lipid metabolism of patients with CKD to monitor the effect of statin treatment. 相似文献
12.
T. P. Kosulina N. V. Bychenko I. P. Morenets L. N. Sorotskaya A. Krutosikova N. I. Val'ter V. G. Kul'nevich 《Chemistry of Heterocyclic Compounds》1998,34(7):855-865
New 2-furyl- and 2-thienylvinyl-4(5H)-oxazolonium perchlorates were synthesized. The action of sodium bicarbonate in 50% aq. ethanol on these salts gave 4(5H)-oxazolones.For Communication 8, see [1].Kuban State Technological University, 350072 Krasnodar, Russia. Slovakian Technical University, Bratislava 81237, Slovakia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 986–998, July, 1998. 相似文献
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14.
Alzbeta Krutosikova Miloslava Dandarova Jana Chylova Daniel Vegh 《Monatshefte für Chemie / Chemical Monthly》1992,123(8-9):807-815
Summary A number of furo[3,2-c]pyridines (4a–4d) and benzo[b]derivative (4e), as well as pyrrolo[2,3-4,5]furo[3,2-c]pyridine (8) were prepared by reaction of the corresponding iminophosphoranes, available from ethyl azidoheteroacrylates and triphenylphosphine, with phenyl isocyanate. The appropriate azidoheteroacrylates were used for the preparation of some substituted furo[3,2-b:4,5-b]dipyrroles (6). The reactions of the prepared compounds are described.
Kondensierte O-, N-Heterocyclen durch Umwandlung von Azidoacrylaten
Zusammenfassung Eine Anzahl von Furo[3,2-c]pyridinen (4a –4d), ein Benzo[b]derivat (4e) und Pyrrolo[2,3:4,5]furo[3,2-c]pyridin (8) wurden durch die Reaktion von Phenylisocyanaten mit den entsprechenden Iminophosphoranen dargestellt, die aus Ethyl-azidoheteroacrylaten und Triphenylphosphin leicht zugänglich sind. Die entsprechenden Azidoacrylate wurden zur Synthese einiger Furo[3,2-b:4,5-b]dipyrrole (6) verwendet. Die Reaktionen einiger dieser Verbindungen werden beschrieben.相似文献
15.
Alzbeta Hutlova Daniel Niznansky Jiri Plocek Josef Bursik Jean-Luc Rehspringer 《Journal of Sol-Gel Science and Technology》2003,26(1-3):473-477
This paper aims to characterise the systems NiFe2O4/SiO2 and CoFe2O4/SiO2 prepared by the sol-gel method. After heat treatment, the various samples have been studied by means of X-ray diffraction, Mössbauer spectroscopy, magnetic measurements and transmission electron microscopy (HR TEM).X-ray diffraction and Mössbauer spectra confirmed the presence of the spinel phase. HR TEM observations revealed the nanocrystals with the size in the range of 2–25 nm. Magnetic measurements showed a superparamagnetic behaviour of the samples heated at lower temperature (800°C) and ferrimagnetic character for the samples heated at higher temperature (900, 1000°C).The final phase composition of the heated samples depends on the preparation conditions. The samples, treated up to 300°C in vacuum and then subsequently heated at 800°C or 900°C, do not contain hematite (the most stable phase at higher temperatures). On the contrary, the samples heated at 1000°C or 1250°C display certain content of hematite. 相似文献
16.
Phenolic profile of edible honeysuckle berries (genus lonicera) and their biological effects 总被引:1,自引:0,他引:1
Jurikova T Rop O Mlcek J Sochor J Balla S Szekeres L Hegedusova A Hubalek J Adam V Kizek R 《Molecules (Basel, Switzerland)》2011,17(1):61-79
The current status of research on polyphenolic compounds in the berries of edible honeysuckle and their biological effects, including recommended utilization, are reviewed. The major classes of phenolic compounds in the blue berried honeysuckle are flavonols (quercetin, rutin, quercitrin) and flavanes (proanthocyanidins, catechins) and anthocyanins. Cyanidin-3-glucoside and cyanidin-3-rutinoside are considered as major anthocyanidins in edible honeysuckle berries. Such a high level of antioxidant activity in the berries of different species of the genus Lonicera is especially due to the high level of polyphenolic compounds, especially anthocyanins. These berries seem to be prospective sources of health-supporting phytochemicals that exhibit beneficial anti-adherence and chemo-protective activities, thus they may provide protection against a number of chronic conditions, e.g., cancer, diabetes mellitus, tumour growth or cardiovascular and neurodegenerative diseases. 相似文献