150kV快前沿低抖动Marx发生器研制

研制了一种主要用于脉冲功率系统前级触发用的Marx发生器,介绍了其工作原理和主要参数。该Marx发生器采用单边充电技术路线和同轴紧凑型结构,高压脉冲采用柔性高压同轴电缆输出,在75Ω匹配负载上获得了超过170kV的高压脉冲输出,脉冲宽度超过200ns,在140~160kV工作区间内其前沿小于3ns,抖动不超过1.5ns。该Marx发生器工作范围宽,稳定可靠,很好地满足了高功率脉冲触发系统的要求。     

Gene-expression profiling in gill and liver of zebrafish exposed to produced water

The effects of produced water (a by-product of oil and gas extraction) on gene expression were studied in gills and liver tissues of zebrafish. Adult, non-breeding zebrafish were exposed to control (freshwater mixed with 5% seawater) or produced water (freshwater mixed with 5% of produced water from the Oceberg C Oil Platform in the North Sea). A zebrafish library was used to make a microarray that consisted of 15,806 unique genes. The results indicate that 27 genes in the gills and 55 genes in the liver show significantly altered expression (greater than two-fold change). More than 70% of these gene sequences have not been annotated in the Gene Ontology (GO) database, making it difficult to characterize the affected genes. CYP1A displayed the greatest upregulation in the gills (eightfold, verified with quantitative real-time PCR). This study illustrates the utility of microarray approaches in investigations of environmental effects of toxicants.     

Five New Nortriterpenoids from the Stems of Schisandra neglecta

Five new nortriterpenoids, schicagenins D–F ( 1 – 3 , resp.) and negleschidilactones A and B ( 4 and 5 , resp.), together with eleven known ones, were isolated from the stems of Schisandra neglecta. Their structures were established on the basis of extensive spectroscopic analyses. All the compounds were evaluated for their activities regarding insulin sensitivity in 3T3‐L1 differentiated adipocytes. None of them showed a significant bioactivity at 10 μM concentration.     

Quantification of L‐ergothioneine in human plasma and erythrocytes by liquid chromatography‐tandem mass spectrometry

A sensitive analytical method has been developed and validated for the quantification of L‐ergothioneine in human plasma and erythrocytes by liquid chromatography‐tandem mass spectrometry. A commercially available isotope‐labeled L‐ergothioneine‐d₉ is used as the internal standard. A simple protein precipitation with acetonitrile is utilized for bio‐sample preparation prior to analysis. Chromatographic separation of L‐ergothioneine is conducted using gradient elution on Alltime C18 (150 mm × 2.1 mm, 5 µ). The run time is 6 min at a constant flow rate of 0.45 ml/min. The mass spectrometer is operated under a positive electrospray ionization condition with multiple reaction monitoring mode. The mass transitions of L‐ergothioneine and L‐ergothioneine‐d₉ are m/z 230 > 127 and m/z 239 > 127, respectively. Excellent linearity [coefficient of determination (r²) ≥ 0.9998] can be achieved for L‐ergothioneine quantification at the ranges of 10 to 10 000 ng/ml, with the intra‐day and inter‐day precisions at 0.9–3.9% and 1.3–5.7%, respectively, and the accuracies for all quality control samples between 94.5 and 101.0%. This validated analytical method is suitable for pharmacokinetic monitoring of L‐ergothioneine in human and erythrocytes. Based on the determination of bio‐samples from five healthy subjects, the mean concentrations of L‐ergothioneine in plasma and erythrocytes are 107.4 ± 20.5 ng/ml and 1285.0 ± 1363.0 ng/ml, respectively. Copyright © 2013 John Wiley & Sons, Ltd.     

A new phenylethanoid glycoside from Isodon sculponeatus

A new phenylethanoid glycoside,seulponisidc(1) was isolated from the aerial parts of Isodon sculponeatus(Vaniot) Kudo, along with six known compounds martynoside(2),verbascoside(3),(+)-hydroxypinoresinol-8-O- β-D-glucoside(4),cedrusin(5), 7-megastigmene-3S,5R,6R,7E,9S-tetrol(6) and 4-oxo- β-ionol- β-D-glucopyranoside(7).Their chemical structures were elucidated from physieochemical data and by acidic hydrolysis.     

一类离散的非线性爆炸方程解的ω极限集

研究了一类离散的非线性爆炸方程．证明了在爆炸占优的条件下,方程解的ω极限集只含有平衡点．     

HTc SQUID磁强计用无磁液氮玻璃钢杜瓦的真空性能研究

提出当对无磁液氮玻璃钢杜瓦抽真空时 ,向无磁液氮玻璃钢杜瓦的真空夹层充注微量的二氧化碳气体 ,所充入的二氧化碳气体就会和玻璃钢表面的氢气、一氧化碳、二氧化碳、甲烷等气体发生协同交换反应 ,使玻璃钢表面的氢气、一氧化碳、二氧化碳、甲烷等气体的脱附速度大大增加 ,减少了抽真空时间。由于无磁液氮玻璃钢杜瓦内使用的活性炭吸附剂对二氧化碳的吸附性能远远大于对玻璃钢材料所放出的氢气、一氧化碳和甲烷等主要气体的吸附性能 ,从而使得抽好真空的无磁液氮玻璃钢杜瓦的真空保持时间大大增加 ,延长了无磁液氮玻璃钢杜瓦的使用寿命     

低温真空下固体界面间接触热导实验分析

主要叙述了低温真空下接触热导实验装置的设计 ,通过改进实验装置来扩展研究的温度范围。在 10 0 K～ 30 0 K范围内 ,对铝、不锈钢和铜三种金属材料进行了大量的接触热导的实验研究 ,并分析了接触热导与界面载荷和温度之间的关系     

吸力面带凹窝轴流风扇内流分析与实验研究

本文采用Navier-Stokes方程和κ-ε两方程模型分别对空调用轴流风轮叶片吸力面设置凹窝和不设置凹窝的的内流特性进行了三维数值模拟,同时对两者的风量噪音特性进行了实验研究.结果表明,在叶片吸力面设置凹窝没有改善风轮的整体流量─压力特性,不能提高风扇的静压升,凹窝只能提高凹窝局部位置的静压升,且凹窝中心压力大,凹窝边缘压力低.小流量时,风扇吸力面设置凹窝反而增加风机噪音,大流量时,凹窝对风机的噪音没有影响.     

Natural Products from Leaves of the Ancient Iranian Medicinal Plant Echium amoenum Fisch. & C. A. Mey.

For several millennia, leaves of Echium amoenum Fisch. & C. A. Mey., an important Iranian medicinal plant with nutritional value as nutraceutical, have been used as tea for the treatment of several conditions, including inflammation. The nutritional value of intake of E. amoenum tea has mainly been correlated to its rich content of mainly water-soluble antioxidants. Although the entire plant is utilized, only natural products of the flowers have previously been thoroughly investigated. The rare natural products bis(3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)-1-(3,4-dihydroxyphenyl)-6,7-dihydroxy-1,2-dihydronaphthalene-2,3-dicarboxylate, 4-Oxy-(E)-caffeoyl-2,3-dihydroxybutanoic acid methyl ester and 4-Oxy-(Z)-caffeoyl-2,3-dihydroxybutanoic acid methyl ester, in addition to the widely distributed compounds rosmarinic acid methyl ester and (E)-caffeic acid, were purified and characterized from leaves of Echium amoenum. The structures were determined by a combination of several 2D NMR spectroscopic techniques, circular dichroism spectroscopy and high-resolution mass spectrometry. The fact that bis(3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)-1-(3,4-dihydroxyphenyl)-6,7-dihydroxy-1,2-dihydronaphthalene-2,3-dicarboxylate belongs to a rare group of natural products which have previously been patented for their significant anti-inflammatory activity may rationalize the traditional treatment of inflammations with E. amoenum.