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41.
Mandrioli R Musenga A Ferranti A Lasaponara SS Fanali S Raggi MA 《Journal of separation science》2005,28(9-10):966-972
A micellar electrokinetic chromatographic method was developed and applied for the first time to the separation and quantification of the main components of cloves, namely eugenol and beta-caryophyllene. The analytes were separated in less than ten minutes in an unmodified fused silica capillary (effective length: 40.0 cm) using a background electrolyte composed of 25 mM carbonate buffer (pH 10.0) and 60 mM sodium dodecylsulfate. Analyte concentrations were determined in clove oil and in methanolic clove extracts after simple sequential dilution with methanol and background electrolyte, and the resulting electropherograms showed no interference due to other components. Precision assays gave satisfactory results, with mean standard deviation of peak areas lower than 4.7% (lower than 1.5% for migration times). The eugenol content of a commercial clove oil was about 70% (RSD% = 3.2), while that of beta-caryophyllene was about 15% (RSD% = 4.2); in clove extracts, on the other hand, eugenol was approximately 15% (RSD% = 4.7) and beta-caryophyllene 4% (RSD% = 5.1). Accuracy was also good (mean recovery >98%). 相似文献
42.
Laura Gagliardi Giorgio Orlandi Fernando Bernardi Alessandro Cembran Marco Garavelli 《Theoretical chemistry accounts》2004,111(2-6):363-372
In the present paper we report the results of a multiconfigurational computational study on potential-energy curves of azobenzene along the NN twisting to clarify the role of this coordinate in the decay of the S2(*) and S1(n*) states. We have found that there is a singlet state, S3 at the trans geometry, on the basis of the doubly excited configuration n2*2, that has a deep minimum at about 90° of twisting, where it is the lowest excited singlet state. The existence of this state provides an explanation for the short lifetime of S2(*) and for the wavelength-dependence of azobenzene photochemistry. We have characterized the S1(n*) state by calculating its vibrational frequencies, which are found to correspond to the recently observed transient Raman spectrum. We have also computed the potential-energy curve for the triplet T1(n*) at the density functional theory B3LYP level, which indicates that in this state the isomerization occurs along the twisting coordinate.Acknowledgement The financial support from MIUR (project Modellistica delle proprietà spettroscopiche di sistemi molecolari complessi funds ex 60% and project Dinamiche molecolari in sistemi di interesse chimico funds ex 40%), from the University of Bologna (Funds for Selected Research Topics) is gratefully acknowledged.Contribution to the Jacopo Tomasi Honorary Issue 相似文献
43.
Alessandro Ferrali 《Tetrahedron letters》2004,45(27):5271-5274
A δ-valerolactam-derived vinyl triflate has been converted into the corresponding vinyl boronate by Pd-catalyzed coupling with bis(pinacolato)diboron, which results in an umpolung. This boronate efficiently couples under Pd catalysis with aryl and heteroaryl bromides to give the corresponding 2-substituted piperidines in excellent yields. 相似文献
44.
Celestino Angeli Renzo Cimiraglia Maurizio Persico Alessandro Toniolo 《Theoretical chemistry accounts》1997,98(1):57-63
We discuss the “three class” approximation to full multireference perturbation CI, which greatly reduces the computational
effort by restricting the summation of diagrams to determinants belonging to a subspace of the zero-order space. In the framework
of the CIPSI algorithm, we propose a new extrapolation procedure allowing recovery of the full “two class” results. The new
procedure is applied to complete active spaces (CAS) and to individually selected zero-order spaces. Comparison with a full
two class calculation on a CAS shows a reduction of computer time of one or two orders of magnitude in the tests presented
here, with an accuracy in the order of 0.1 kcal/mol. Our procedure can thus compete with the CASPT2 algorithm, specifically
conceived to deal with CAS. In the case of selected zero-order spaces, the speed-up is less dramatic but the method still
retains its advantages.
Received: 12 June 1997 / Accepted: 31 July 1997 相似文献
45.
Alessandro Pezzella Liliana Lista Alessandra Napolitano Marco d’Ischia 《Tetrahedron letters》2005,46(20):3541-3544
A one-pot procedure for the preparation of catecholestrogens in over 90% yield is reported, involving oxygenation of 17β-estradiol or estrone with o-iodoxybenzoic acid (IBX) followed by reduction with methanolic NaBH4. The procedure, which was extended to the o-hydroxylation of a number of representative phenols in good-to-high yields, expands significantly the scope of phenolic oxidation mediated by IBX. 相似文献
46.
Alessandro D'Aprano Dorina I. Donato Eugenio Caponetti 《Journal of solution chemistry》1979,8(2):135-146
Dielectric constants (measured at 1 MHz) are reported for solutions of water (concentration range 0 to 0.2 mole fraction)
in 1-propanol at 25°C, and in 1-butanol, 1-pentanol, and 1-hexanol at 15, 25, 35, and 45°C. These results, together with literature
values for solutions of water in methanol, ethanol, 1-heptanol, and 1-octanol, show that water interacts with alcohols in
at least two ways: (1) it can participate in the formation of dynamic hydrogen-bonded chains, thereby raising the polarizability;
(2) it can form relatively stable structures such as H2O(ROH)4 which have zero net dipole moment and consequently diminish volume polarizability. For C
n
H
2n+1
OH alcohols,n≥4, most of the initially added water forms complexes: consequently, addition of water to these alcohols lowers the dielectric
constant. 相似文献
47.
Abbotto A Bradamante S Capri N Rzepa H Williams DJ White A 《The Journal of organic chemistry》1996,61(5):1770-1778
Enamines and enol ethers substituted in the beta position by the 2-benzoxazolyl and 2-benzothiazolyl group have been obtained by condensing dimethylformamide dimethyl acetal and ethyl orthoformate, respectively, with bis(2-benzoxazolyl)methane and bis(2-benzothiazolyl)methane. A dynamic NMR and semiempirical (PM3) investigation on rotational energy barriers has been carried out in order to rank the electron-withdrawing capacity of the heterocyclic rings. The NMR-based evaluation of the energy barriers corresponding to the rotation along the enaminic double bond has shown that the pi-electron-withdrawing power of benzothiazole is larger than that of benzoxazole, in full accord with previously obtained charge demand values based on (13)C and (15)N pi-charge/shift relationships. The NMR and the computational approaches have led to consistent results. The X-ray crystal structure of alpha,alpha-bis(2-benzothiazolyl)-beta-(dimethylamino)ethene shows that only one heteroaryl ring is coplanar with the enaminic double bond, while the second one is twisted by 73 degrees relative to such a plane. Moreover, in this case calculations closely reproduce the experimental results. In the calculated transition states corresponding to the rotational process along the enamine double bond, the two heteroaryl groups become coplanar and conjugation develops between the enaminic nitrogen electron pool and both heterocycles. The lower rotational barrier observed in the case of the 2-benzothiazolyl derivatives, with respect to the 2-benzoxazolyl derivatives, is therefore a direct consequence of the higher electron-withdrawing power of the former group. Furthermore, a stabilizing intramolecular nonbonded S.S interaction in the rotational transition state of the benzothiazolyl derivatives is evidenced by the calculations. An unprecedented isolation of the NH-enamine tautomer involving the benzoxazolyl and benzothiazolyl ring in alpha,alpha-diheteroacetaldehydes has been performed, confirming these heterocycles as strong electron-withdrawing substituents. 相似文献
48.
Samorì P Yin X Tchebotareva N Wang Z Pakula T Jäckel F Watson MD Venturini A Müllen K Rabe JP 《Journal of the American Chemical Society》2004,126(11):3567-3575
We report the synthesis and characterization of covalent dyads and multiads of electron acceptors (A) and donors (D), with the purpose of exploiting their nanophase separation behavior toward (a) two-dimensional (2D) surface patterning with well-defined integrated arrays of dissimilar molecular electronic features and (b) bulk self-assembly to noncovalent columnar versions of the so-called "double cable" systems, the likes of which could eventually provide side-by-side percolation pathways for electrons and holes in solar cells. Soluble, alkylated hexa-peri-hexabenzocoronenes (HBCs) bearing tethered anthraquinones (AQs) are shown by scanning tunneling microscopy (STM) to self-assemble at the solution-graphite interface into either defect-rich polycrystalline monolayers or extended 2D crystalline domains, depending on the number of tethered AQs. In the bulk, the thermal stability of the room-temperature HBC columnar phase is increased, which is attributed to the desired nanotriphase separation of HBC columns, insulating alkyl sheaths, and AQ units. Homeotropic alignment (columns normal to surfaces), predicted to be ideal for potential exploitation of such "double cables" in photovoltaic devices, is demonstrated. 相似文献
49.
Castagnola M Rossetti DV Inzitari R Vitali A Lupi A Zuppi C Cabras T Fadda MB Petruzzelli R Giardina B Messana I 《Electrophoresis》2003,24(5):801-807
Measurements by capillary electrophoresis (CE) of bacitracin A(1) effective mobility at different pH values permitted to estimate the five acidic dissociation constants and the Stokes radii at different protonation stages of the macrocyclic dodecapeptide. The pK(a) values were 3.6 and 4.4 for the two carboxylic groups of the lateral chains of D-Asp-11 and D-Glu-4, respectively, 6.4 for the aza-atom of the imidazole ring of His-10, 7.6 for the amino group of N-terminal Ile-1 and 9.7 for the delta-amino group of D-Orn-7, very close to the values obtained by other researchers by titration experiments. In agreement with a rigid macrocyclic structure the Stokes radii of different protonated forms ranged only between 14.3 and 14.8 A. Best fitting procedures performed on experimental mobility measured at two different pH values (5.50 and 6.72) in the presence of increasing Zn(+2) concentration allowed confirming the model that assumes the binding of Zn(+2) to P(0) peptide form with a 1.5 x 10(3) M(-1) intrinsic association constant. Following to Zn(+2) binding, the pK(a) of the amino group of N-terminal Ile-1 is shifted from 7.6 to 5.9 and the Stokes radius is reduced of about 3 A. The mean charge of the bacitracin A(1)-Zn(+2) complex resulted +1.67 and +1.12 at pH 5.50 and 6.72, respectively. These results suggest that the amino group of N-terminal Ile-1 is not essential for Zn(+2) binding. 相似文献
50.
Roberto Dallocchio Barbara Sechi Alessandro Dessì Bezhan Chankvetadze Sergio Cossu Victor Mamane Robin Weiss Patrick Pale Paola Peluso 《Electrophoresis》2021,42(17-18):1853-1863
2’-(4-Pyridyl)- and 2’-(4-hydroxyphenyl)-TCIBPs (TCIBP = 3,3’,5,5’-tetrachloro-2-iodo-4,4’-bipyridyl) are chiral compounds that showed interesting inhibition activity against transthyretin fibrillation in vitro. We became interested in their enantioseparation since we noticed that the M-stereoisomer is more effective than the P-enantiomer. Based thereon, we recently reported the enantioseparation of 2’-substituted TCIBP derivatives with amylose-based chiral columns. Following this study, herein we describe the comparative enantioseparation of both 2’-(4-pyridyl)- and 2’-(4-hydroxyphenyl)-TCIBPs on four cellulose phenylcarbamate-based chiral columns aiming to explore the effect of the polymer backbone, as well as the nature and position of substituents on the side groups on the enantioseparability of these compounds. In the frame of this project, the impact of subtle variations of analyte and polysaccharide structures, and mobile phase (MP) polarity on retention and selectivity was evaluated. The effect of temperature on retention and selectivity was also considered, and overall thermodynamic parameters associated with the analyte adsorption onto the CSP surface were derived from van ’t Hoff plots. Interesting cases of enantiomer elution order (EEO) reversal were observed. In particular, the EEO was shown to be dependent on polysaccharide backbone, the elution sequence of the two analytes being P-M and M-P on cellulose and amylose tris(3,5-dimethylphenylcarbamate), respectively. In this regard, a theoretical investigation based on molecular dynamics (MD) simulations was performed by using amylose and cellulose tris(3,5-dimethylphenylcarbamate) nonamers as virtual models of the polysaccharide-based selectors. This exploration at the molecular level shed light on the origin of the enantiodiscrimination processes. 相似文献